Protein: ACE
Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form]

Gene: ACE
Organism: Homo sapiens
Interactions: 21
UniProt ID: P12821

Gene Ontology (top 5):
GO:0001822 - kidney development
GO:0001974 - blood vessel remodeling
GO:0002003 - angiotensin maturation
GO:0002019 - regulation of renal output by angiotensin
GO:0002446 - neutrophil mediated immunity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369534

ANGT
Angiotensinogen

3

3

Small-scale

0.646

High

555812

BKRB2
B2 bradykinin receptor

1

2

Small-scale

0.561

High

480671

LEG1
Galectin-1

1

1

High-throughput

0.536

High

555819

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

555813

MYH9
Myosin-9

1

3

Small-scale

0.527

High

555815

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.505

High

431676

ITB1
Integrin beta-1

1

3

Small-scale

0.479

High

555809

ITB5
Integrin beta-5

1

3

Small-scale

0.479

High

555814

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.479

High

555816

EWS
RNA-binding protein EWS

1

3

High-throughput

0.479

High

555821

HOOK1
Protein Hook homolog 1

1

4

High-throughput

0.479

High

352907

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

450326

ACBP
Acyl-CoA-binding protein

1

0

High-throughput

0.458

High

555818

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.458

High

555811

DDX6
Probable ATP-dependent RNA helicase DDX6

1

4

Small-scale

0.445

High

385407

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

8

High-throughput

0.437

High

555817

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

1

High-throughput

0.437

High

555822

NINL
Ninein-like protein

1

7

High-throughput

0.437

High

555810

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.426

High

136049

PLK4
Serine/threonine-protein kinase PLK4

1

0

High-throughput

0.279

Low

555820

METL9
Protein-L-histidine N-pros-methyltransferase

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025