Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: FBX22 (Q8NEZ5)
F-box only protein 22 (F-box protein FBX22p44)
Gene: FBXO22

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.827

The method score is based on:

Property Details
Experiments 32929329, 35509820, 35256949
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains F-box~ubiquitin
Common GO terms GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
and 2 others

more...

Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 465
Hs

1 403
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024