Protein: FILA2
Filaggrin-2 (FLG-2) (Intermediate filament-associated and psoriasis-susceptibility protein) (Ifapsoriasin)

Gene: FILA2, FLG2
Organism: Homo sapiens
Interactions: 121
UniProt ID: Q5D862

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0005198 - structural molecule activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

529220

CFTR
Cystic fibrosis transmembrane conductance regulator

2

8

High-throughput

0.628

High

1125328

FGRL1
Fibroblast growth factor receptor-like 1

1

5

High-throughput

0.618

High

386865

P53
Cellular tumor antigen p53

1

17

Small-scale

0.618

High

427577

ANXA2
Annexin A2

1

16

High-throughput

0.618

High

596289

FILA
Filaggrin

1

18

High-throughput

0.618

High

1125327

HORN
Hornerin

1

20

High-throughput

0.618

High

1125357

PD1L1
Programmed cell death 1 ligand 1

1

5

High-throughput

0.553

High

497147

TAU
Microtubule-associated protein tau

2

15

Small-scale

0.552

High

365200

FRIH
Ferritin heavy chain

1

3

High-throughput

0.536

High

414949

CDK1
Cyclin-dependent kinase 1

1

10

High-throughput

0.536

High

601272

VDAC1
Voltage-dependent anion-selective channel protein 1

1

1

High-throughput

0.536

High

616818

JAK1
Tyrosine-protein kinase JAK1

1

10

High-throughput

0.536

High

624442

CCNC
Cyclin-C

1

6

High-throughput

0.536

High

1029250

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

High-throughput

0.536

High

1062738

FL2D
Pre-mRNA-splicing regulator WTAP

1

1

High-throughput

0.536

High

1125323

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

4

High-throughput

0.536

High

1125335

CSN5
COP9 signalosome complex subunit 5

1

6

High-throughput

0.536

High

1125340

GMCL1
Germ cell-less protein-like 1

1

7

High-throughput

0.536

High

1125350

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

4

High-throughput

0.536

High

779536

CCNF
Cyclin-F

1

7

High-throughput

0.515

High

1125339

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

431934

HS90A
Heat shock protein HSP 90-alpha

1

5

Small-scale

0.501

High

1125336

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

High-throughput

0.501

High

1125360

PADI1
Protein-arginine deiminase type-1

1

4

Small-scale

0.501

High

1125361

PADI3
Protein-arginine deiminase type-3

1

4

Small-scale

0.501

High

1125364

PADI2
Protein-arginine deiminase type-2

1

4

Small-scale

0.501

High

275022

RENR
Renin receptor

1

3

High-throughput

0.489

High

725807

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.489

High

821569

PTSS1
Phosphatidylserine synthase 1

1

5

High-throughput

0.489

High

882745

STX17
Syntaxin-17

1

2

High-throughput

0.489

High

1041353

CUL2
Cullin-2

1

15

High-throughput

0.489

High

1065932

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

2

High-throughput

0.489

High

1125343

SH23A
SH2 domain-containing protein 3A

1

12

High-throughput

0.489

High

1125352

TSSP
Thymus-specific serine protease

1

1

High-throughput

0.489

High

1125355

TB22B
TBC1 domain family member 22B

1

5

High-throughput

0.489

High

62596

DPRX
Divergent paired-related homeobox

1

13

High-throughput

0.479

High

134073

DDX3X
ATP-dependent RNA helicase DDX3X

1

8

Small-scale

0.479

High

227660

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

233495

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

260496

PITX3
Pituitary homeobox 3

1

13

Small-scale

0.479

High

282673

RNF8
E3 ubiquitin-protein ligase RNF8

1

12

High-throughput

0.479

High

298567

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

369752

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

374343

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

14

High-throughput

0.479

High

379477

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.479

High

450895

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.479

High

453400

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

5

High-throughput

0.479

High

455516

PARP1
Poly [ADP-ribose] polymerase 1

1

11

High-throughput

0.479

High

456585

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

5

Small-scale

0.479

High

505227

EGR2
E3 SUMO-protein ligase EGR2

1

9

High-throughput

0.479

High

542349

PLAK
Junction plakoglobin

1

10

High-throughput

0.479

High

551537

TFE2
Transcription factor E2-alpha

1

2

High-throughput

0.479

High

551730

DESP
Desmoplakin

1

3

High-throughput

0.479

High

590963

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

625483

CDK2
Cyclin-dependent kinase 2

1

10

High-throughput

0.479

High

683094

CASPE
Caspase-14

1

4

High-throughput

0.479

High

795760

MAGA3
Melanoma-associated antigen 3

1

5

Small-scale

0.479

High

808673

YAP1
Transcriptional coactivator YAP1

1

11

High-throughput

0.479

High

851333

NEK2
Serine/threonine-protein kinase Nek2

1

9

Small-scale

0.479

High

908657

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

959457

VIGLN
Vigilin

1

4

High-throughput

0.479

High

969753

KIF23
Kinesin-like protein KIF23

1

13

High-throughput

0.479

High

970787

DSG1
Desmoglein-1

1

6

High-throughput

0.479

High

980267

K1C17
Keratin, type I cytoskeletal 17

1

4

High-throughput

0.479

High

993958

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

6

High-throughput

0.479

High

995974

DSC1
Desmocollin-1

1

3

High-throughput

0.479

High

1018521

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

16

High-throughput

0.479

High

1043033

CUL4A
Cullin-4A

1

15

High-throughput

0.479

High

1045962

PKP1
Plakophilin-1

1

9

High-throughput

0.479

High

1046063

DX39B
Spliceosome RNA helicase DDX39B

1

8

High-throughput

0.479

High

1059662

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

14

High-throughput

0.479

High

1064379

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1080011

EZH2
Histone-lysine N-methyltransferase EZH2

1

13

High-throughput

0.479

High

1116306

LARP7
La-related protein 7

1

6

High-throughput

0.479

High

1125314

KPRP
Keratinocyte proline-rich protein

1

2

High-throughput

0.479

High

1125317

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

1125321

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.479

High

1125326

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.479

High

1125333

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

4

High-throughput

0.479

High

1125338

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.479

High

1125341

SPB12
Serpin B12

1

9

High-throughput

0.479

High

1125342

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1125344

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

20

High-throughput

0.479

High

1125345

ACE2
Angiotensin-converting enzyme 2

1

4

High-throughput

0.479

High

1125354

FBX6
F-box only protein 6

1

4

High-throughput

0.479

High

1125356

ARL8B
ADP-ribosylation factor-like protein 8B

1

4

High-throughput

0.479

High

1125358

ZRAN1
Ubiquitin thioesterase ZRANB1

1

20

High-throughput

0.479

High

1125362

FZR1
Fizzy-related protein homolog

1

7

High-throughput

0.479

High

1125363

FBW1A
F-box/WD repeat-containing protein 1A

1

9

High-throughput

0.479

High

1125365

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

13

Small-scale

0.479

High

396248

ARGI1
Arginase-1

1

0

High-throughput

0.458

High

1125316

ARM12
Armadillo repeat-containing protein 12

1

0

Small-scale

0.458

High

1125318

CDC73
Parafibromin

1

0

High-throughput

0.458

High

1125319

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

1125322

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

1125332

STAG1
Cohesin subunit SA-1

1

0

High-throughput

0.458

High

1046694

KLF5
Krueppel-like factor 5

1

16

High-throughput

0.457

High

891178

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

18

High-throughput

0.445

High

1125313

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

1125329

RYBP
RING1 and YY1-binding protein

1

4

High-throughput

0.445

High

1125334

ESR2
Estrogen receptor beta

1

20

High-throughput

0.445

High

1125359

AGO1
Protein argonaute-1

1

2

High-throughput

0.445

High

950632

ARF5
ADP-ribosylation factor 5

1

3

High-throughput

0.437

High

1063847

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.437

High

1125320

RICTR
Rapamycin-insensitive companion of mTOR

1

3

High-throughput

0.437

High

1125337

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

5

Small-scale

0.437

High

1125347

DDX24
ATP-dependent RNA helicase DDX24

1

9

High-throughput

0.437

High

1125351

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

7

High-throughput

0.437

High

1125353

ANLN
Anillin

1

8

High-throughput

0.437

High

1125330

ZN808
Zinc finger protein 808

1

0

High-throughput

0.426

High

1066

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

789286

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.407

High

1125331

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

7

High-throughput

0.407

High

1125346

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

18

High-throughput

0.407

High

1125348

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

18

High-throughput

0.407

High

1125349

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

18

High-throughput

0.407

High

1125324

AROS
Active regulator of SIRT1

1

0

High-throughput

0.279

Low

929772

KCNJ2
Inward rectifier potassium channel 2

1

0

Small-scale

0.249

Low

1062233

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

0

High-throughput

0.249

Low

1125315

KPLCE
Protein KPLCE

1

0

High-throughput

0.249

Low

1125325

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024