HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: UBS3B (Q8TF42)
Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)
Gene: UBASH3B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.681

Property	Details
Experiments	17599067
Identification Methods	pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH3_9~ubiquitin, UBA~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 649
+	Hs
		227000 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBS3A_HUMAN (12-643): 0: 947: 43.37
+	Hs
		476098 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBS3B_HUMAN (1-649): 0: 1066: 100.00
+	Hs
		475540 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBS3A_HUMAN (12-643): 0: 947: 43.37
+	Hs
		227109 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		227228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBXN1_HUMAN (35-97): 3.55e-22: 99.1: 47.69
+	Hs
		228156 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SH3R3_HUMAN (195-315): 4.01e-15: 81.4: 22.13
+	Hs
		227474 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LASP1_HUMAN (254-315): 1.29e-12: 70.2: 30.65
+	Dm
		1197424 LUBEL_DROME (55-453): 1.14e-66: 234: 16.95		Q86P80_DROME (186-317): 1.5e-34: 141: 24.27
+	Dm
		52991 LUBEL_DROME (55-453): 1.14e-66: 234: 16.95		A1Z866_DROME (186-317): 1.6e-34: 141: 24.27
+	Hs
		474986 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		475592 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Xl
		1155575 Q7SY79_XENLA (1-149): 2.25e-49: 179: 19.33		SH3R1_XENLA (219-315): 2.75e-15: 81.8: 25.77
+	Hs
		476167 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Hs
		475650 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBXN1_HUMAN (35-97): 3.55e-22: 99.1: 47.69
+	Hs
		475981 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SH3R1_HUMAN (216-315): 3.02e-18: 91.4: 28.00
+	Hs
		476095 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SH3R3_HUMAN (195-315): 4.01e-15: 81.4: 22.13