Protein: TAU
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)

Gene: TAU, Mapt
Organism: Rattus norvegicus
Interactions: 178
UniProt ID: P19332

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0001764 - neuron migration
GO:0003677 - DNA binding
GO:0005576 - extracellular region
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

580723

MTAP2
Microtubule-associated protein 2

1

16

High-throughput

0.575

High

620107

AATF
Protein AATF

1

2

Small-scale

0.515

High

444693

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

13

High-throughput

0.484

High

444707

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

1

13

High-throughput

0.484

High

620035

RAN
GTP-binding nuclear protein Ran

1

15

High-throughput

0.484

High

620048

AP2M1
AP-2 complex subunit mu

1

9

High-throughput

0.484

High

620066

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

4

High-throughput

0.484

High

620084

BAIP2
BAR/IMD domain-containing adapter protein 2

1

17

High-throughput

0.484

High

620063

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

Small-scale

0.479

High

620104

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

5

Small-scale

0.479

High

620106

G37L1
G-protein coupled receptor 37-like 1

1

0

High-throughput

0.464

High

60878

TOLIP
Toll-interacting protein

1

2

High-throughput

0.445

High

67964

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

15

High-throughput

0.445

High

72452

H2AJ
Histone H2A.J

1

12

High-throughput

0.445

High

81627

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

4

High-throughput

0.445

High

93204

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

7

High-throughput

0.445

High

117851

DYH5
Dynein axonemal heavy chain 5

1

6

High-throughput

0.445

High

148044

PI4KA
Phosphatidylinositol 4-kinase alpha

1

3

High-throughput

0.445

High

148788

AMPB
Aminopeptidase B

1

4

High-throughput

0.445

High

204211

NCDN
Neurochondrin

1

3

High-throughput

0.445

High

204636

DNM1L
Dynamin-1-like protein

1

13

High-throughput

0.445

High

205569

STIP1
Stress-induced-phosphoprotein 1

1

9

High-throughput

0.445

High

205642

AFAD
Afadin

1

20

High-throughput

0.445

High

266830

TRIM3
Tripartite motif-containing protein 3

1

16

High-throughput

0.445

High

267188

ANK3
Ankyrin-3

1

16

High-throughput

0.445

High

312680

HSP74
Heat shock 70 kDa protein 4

1

19

High-throughput

0.445

High

421243

ALDOA
Fructose-bisphosphate aldolase A

1

5

High-throughput

0.445

High

426165

EF2
Elongation factor 2

1

6

High-throughput

0.445

High

432398

HXK1
Hexokinase-1

1

3

High-throughput

0.445

High

444715

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

13

High-throughput

0.445

High

448090

BIP
Endoplasmic reticulum chaperone BiP

1

16

High-throughput

0.445

High

450753

CALB1
Calbindin

1

12

High-throughput

0.445

High

456070

ENOG
Gamma-enolase

1

7

High-throughput

0.445

High

456172

KCRB
Creatine kinase B-type

1

7

High-throughput

0.445

High

456298

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

7

High-throughput

0.445

High

459378

MAG
Myelin-associated glycoprotein

1

15

High-throughput

0.445

High

469962

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

14

High-throughput

0.445

High

479234

ALDOC
Fructose-bisphosphate aldolase C

1

5

High-throughput

0.445

High

486832

PYGL
Glycogen phosphorylase, liver form

1

10

High-throughput

0.445

High

486833

PYGM
Glycogen phosphorylase, muscle form

1

10

High-throughput

0.445

High

488666

SYN1
Synapsin-1

1

20

High-throughput

0.445

High

518575

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

9

High-throughput

0.445

High

532011

ATPB
ATP synthase F(1) complex catalytic subunit beta, mitochondrial

1

9

High-throughput

0.445

High

533460

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

2

High-throughput

0.445

High

540121

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

14

High-throughput

0.445

High

543313

CLH1
Clathrin heavy chain 1

1

5

High-throughput

0.445

High

547300

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

14

High-throughput

0.445

High

548656

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

16

High-throughput

0.445

High

550708

KPYM
Pyruvate kinase PKM

1

4

High-throughput

0.445

High

555550

FAS
Fatty acid synthase

1

6

High-throughput

0.445

High

556456

NFM
Neurofilament medium polypeptide

1

20

High-throughput

0.445

High

561012

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

3

High-throughput

0.445

High

581941

MAP1B
Microtubule-associated protein 1B

1

20

High-throughput

0.445

High

590762

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

9

High-throughput

0.445

High

590966

S25A3
Solute carrier family 25 member 3

1

18

High-throughput

0.445

High

591434

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

19

High-throughput

0.445

High

598245

PGK1
Phosphoglycerate kinase 1

1

4

High-throughput

0.445

High

598350

ACLY
ATP-citrate synthase

1

7

High-throughput

0.445

High

599258

NFH
Neurofilament heavy polypeptide

1

20

High-throughput

0.445

High

614859

AP2A2
AP-2 complex subunit alpha-2

1

20

High-throughput

0.445

High

619987

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

4

High-throughput

0.445

High

619988

NFL
Neurofilament light polypeptide

1

20

High-throughput

0.445

High

619989

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

20

High-throughput

0.445

High

619990

DYN1
Dynamin-1

1

12

High-throughput

0.445

High

619991

AINX
Alpha-internexin

1

20

High-throughput

0.445

High

619992

EAA1
Excitatory amino acid transporter 1

1

5

High-throughput

0.445

High

619993

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

6

High-throughput

0.445

High

619995

PARP1
Poly [ADP-ribose] polymerase 1

1

12

High-throughput

0.445

High

619996

DCTN1
Dynactin subunit 1

1

17

High-throughput

0.445

High

619997

SYT2
Synaptotagmin-2

1

10

High-throughput

0.445

High

619998

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

2

High-throughput

0.445

High

619999

MIF
Macrophage migration inhibitory factor

1

2

High-throughput

0.445

High

620000

EAA2
Excitatory amino acid transporter 2

1

5

High-throughput

0.445

High

620001

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

5

High-throughput

0.445

High

620002

HS90B
Heat shock protein HSP 90-beta

1

10

High-throughput

0.445

High

620003

MAP1A
Microtubule-associated protein 1A

1

20

High-throughput

0.445

High

620005

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

5

High-throughput

0.445

High

620006

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

6

High-throughput

0.445

High

620007

KAD1
Adenylate kinase isoenzyme 1

1

3

High-throughput

0.445

High

620008

LDHB
L-lactate dehydrogenase B chain

1

6

High-throughput

0.445

High

620009

COF1
Cofilin-1

1

8

High-throughput

0.445

High

620010

RP3A
Rabphilin-3A

1

10

High-throughput

0.445

High

620011

GFAP
Glial fibrillary acidic protein

1

20

High-throughput

0.445

High

620012

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

9

High-throughput

0.445

High

620013

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

9

High-throughput

0.445

High

620014

DPYL2
Dihydropyrimidinase-related protein 2

1

9

High-throughput

0.445

High

620016

HSPA9
Stress-70 protein, mitochondrial

1

19

High-throughput

0.445

High

620018

GDIA
Rab GDP dissociation inhibitor alpha

1

5

High-throughput

0.445

High

620020

IMB1
Importin subunit beta-1

1

11

High-throughput

0.445

High

620021

PYC
Pyruvate carboxylase, mitochondrial

1

3

High-throughput

0.445

High

620022

PYGB
Glycogen phosphorylase, brain form

1

10

High-throughput

0.445

High

620023

SNAA
Alpha-soluble NSF attachment protein

1

5

High-throughput

0.445

High

620024

NCKP1
Nck-associated protein 1

1

3

High-throughput

0.445

High

620025

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

18

High-throughput

0.445

High

620026

MYPR
Myelin proteolipid protein

1

9

High-throughput

0.445

High

620027

SNP25
Synaptosomal-associated protein 25

1

4

High-throughput

0.445

High

620028

ARF3
ADP-ribosylation factor 3

1

13

High-throughput

0.445

High

620029

STXB1
Syntaxin-binding protein 1

1

7

High-throughput

0.445

High

620030

1433G
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]

1

20

High-throughput

0.445

High

620031

1433E
14-3-3 protein epsilon

1

7

High-throughput

0.445

High

620032

EF1A2
Elongation factor 1-alpha 2

1

9

High-throughput

0.445

High

620033

H4
Histone H4 [Cleaved into: Osteogenic growth peptide

1

8

High-throughput

0.445

High

620034

VATB2
V-type proton ATPase subunit B, brain isoform

1

6

High-throughput

0.445

High

620036

AP2B1
AP-2 complex subunit beta

1

20

High-throughput

0.445

High

620037

HINT1
Adenosine 5'-monophosphoramidase HINT1

1

3

High-throughput

0.445

High

620038

CH60
60 kDa heat shock protein, mitochondrial

1

7

High-throughput

0.445

High

620039

MK01
Mitogen-activated protein kinase 1

1

9

High-throughput

0.445

High

620040

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.445

High

620041

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

20

High-throughput

0.445

High

620042

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

14

High-throughput

0.445

High

620043

1433T
14-3-3 protein theta

1

20

High-throughput

0.445

High

620044

KPCB
Protein kinase C beta type

1

14

High-throughput

0.445

High

620045

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

12

High-throughput

0.445

High

620046

HS90A
Heat shock protein HSP 90-alpha

1

10

High-throughput

0.445

High

620047

ARF2
ADP-ribosylation factor 2

1

13

High-throughput

0.445

High

620051

FSCN1
Fascin

1

4

High-throughput

0.445

High

620052

PURA
Transcriptional activator protein Pur-alpha

1

3

High-throughput

0.445

High

620053

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

12

High-throughput

0.445

High

620054

H2B1
Histone H2B type 1

1

20

High-throughput

0.445

High

620055

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

15

High-throughput

0.445

High

620056

AP180
Clathrin coat assembly protein AP180

1

14

High-throughput

0.445

High

620057

ADT1
ADP/ATP translocase 1

1

11

High-throughput

0.445

High

620058

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

3

High-throughput

0.445

High

620059

DYN3
Dynamin-3

1

13

High-throughput

0.445

High

620060

ADT2
ADP/ATP translocase 2

1

11

High-throughput

0.445

High

620061

CYTSA
Cytospin-A

1

15

High-throughput

0.445

High

620062

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

High-throughput

0.445

High

620065

TBB2B
Tubulin beta-2B chain

1

17

High-throughput

0.445

High

620067

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

3

High-throughput

0.445

High

620068

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

2

High-throughput

0.445

High

620069

NONO
Non-POU domain-containing octamer-binding protein

1

18

High-throughput

0.445

High

620070

IMPCT
Protein IMPACT

1

1

High-throughput

0.445

High

620071

AKA12
A-kinase anchor protein 12

1

20

High-throughput

0.445

High

620072

PHB2
Prohibitin-2

1

8

High-throughput

0.445

High

620073

SYNJ1
Synaptojanin-1

1

5

High-throughput

0.445

High

620074

DPYL1
Dihydropyrimidinase-related protein 1

1

9

High-throughput

0.445

High

620075

SYN2
Synapsin-2

1

15

High-throughput

0.445

High

620076

MAP6
Microtubule-associated protein 6

1

18

High-throughput

0.445

High

620077

S12A5
Solute carrier family 12 member 5

1

3

High-throughput

0.445

High

620078

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

High-throughput

0.445

High

620079

SRC8
Src substrate cortactin

1

20

High-throughput

0.445

High

620080

TCPE
T-complex protein 1 subunit epsilon

1

12

High-throughput

0.445

High

620081

CSN4
COP9 signalosome complex subunit 4

1

3

High-throughput

0.445

High

620082

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

6

High-throughput

0.445

High

620083

DCTN2
Dynactin subunit 2

1

3

High-throughput

0.445

High

620085

PLAK
Junction plakoglobin

1

19

High-throughput

0.445

High

620086

TBA1B
Tubulin alpha-1B chain

1

17

High-throughput

0.445

High

620087

VATE1
V-type proton ATPase subunit E 1

1

3

High-throughput

0.445

High

620088

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

18

High-throughput

0.445

High

620090

TCPD
T-complex protein 1 subunit delta

1

12

High-throughput

0.445

High

620092

NDRG2
Protein NDRG2

1

4

High-throughput

0.445

High

620093

CSKI1
Caskin-1

1

20

High-throughput

0.445

High

620094

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

20

High-throughput

0.445

High

620096

CLAP2
CLIP-associating protein 2

1

11

High-throughput

0.445

High

620098

PABP1
Polyadenylate-binding protein 1

1

13

High-throughput

0.445

High

620099

ACON
Aconitate hydratase, mitochondrial

1

3

High-throughput

0.445

High

620100

WDR7
WD repeat-containing protein 7

1

12

High-throughput

0.445

High

620101

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

2

High-throughput

0.445

High

620102

MYH10
Myosin-10

1

9

High-throughput

0.445

High

620103

NSF
Vesicle-fusing ATPase

1

8

High-throughput

0.445

High

620105

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

20

High-throughput

0.445

High

620108

PRDX5
Peroxiredoxin-5, mitochondrial

1

2

High-throughput

0.445

High

620109

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

13

High-throughput

0.445

High

620110

PUF60
Poly(U)-binding-splicing factor PUF60

1

13

High-throughput

0.445

High

620111

SEPT7
Septin-7

1

15

High-throughput

0.445

High

620015

NPTX1
Neuronal pentraxin-1

1

2

High-throughput

0.442

High

470173

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

6

High-throughput

0.407

High

619994

KCRU
Creatine kinase U-type, mitochondrial

1

7

High-throughput

0.407

High

620004

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

3

High-throughput

0.407

High

620017

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

7

High-throughput

0.407

High

620019

GABT
4-aminobutyrate aminotransferase, mitochondrial

1

4

High-throughput

0.407

High

620049

ACTZ
Alpha-centractin

1

20

High-throughput

0.407

High

620050

EFTU
Elongation factor Tu, mitochondrial

1

10

High-throughput

0.407

High

620064

MIC60
MICOS complex subunit Mic60

1

4

High-throughput

0.407

High

620089

TOM70
Mitochondrial import receptor subunit TOM70

1

14

High-throughput

0.407

High

620091

QCR8
Cytochrome b-c1 complex subunit 8

1

1

High-throughput

0.407

High

620095

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

4

High-throughput

0.407

High

620097

IDH3A
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

6

High-throughput

0.407

High


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Last updated: 11Aug2025