HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SHIP1 (Q92835)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)
Gene: INPP5D

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0017124 - SH3 domain binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 1189
+	Hs
		226647 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		I5P2_HUMAN (284-836): 3.19e-145: 465: 21.76
+	Hs
		227206 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		OCRL_HUMAN (269-781): 8.78e-142: 453: 23.43
+	Hs
		176358 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SHIP2_HUMAN (3-1169): 0: 697: 39.77
+	Hs
		228525 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		INP5K_HUMAN (391-800): 6.12e-108: 348: 21.28
+	Hs
		475170 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		INP5K_HUMAN (391-800): 6.12e-108: 348: 21.28
+	Mm
		88466 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		D3Z656_MOUSE (695-1118): 5.16e-11: 69.6: 8.53
+	Dm
		1179001 Q9W418_DROME (1-77): 5.42e-30: 124: 32.47		Q7K161_DROME (399-741): 4.78e-102: 328: 28.01
+	At
		1092068 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		IP5P2_ARATH (462-740): 1.43e-97: 326: 24.11