Protein: PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4)

Gene: PPIL4
Organism: Homo sapiens
Interactions: 166
UniProt ID: Q8WUA2

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1356390

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

4

4

Small-scale

0.694

High

625521

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.691

High

1356402

NSRP1
Nuclear speckle splicing regulatory protein 1

3

1

High-throughput

0.656

High

1311815

DHX40
Probable ATP-dependent RNA helicase DHX40

3

5

High-throughput

0.650

High

211373

RFOX2
RNA binding protein fox-1 homolog 2

1

5

High-throughput

0.621

High

157658

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.618

High

173131

XPO1
Exportin-1

1

1

High-throughput

0.618

High

349177

LATS1
Serine/threonine-protein kinase LATS1

1

2

High-throughput

0.618

High

401199

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.618

High

650869

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

Small-scale

0.618

High

655281

SFPQ
Splicing factor, proline- and glutamine-rich

1

2

High-throughput

0.618

High

775219

FUS
RNA-binding protein FUS

1

6

High-throughput

0.618

High

877185

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.618

High

885854

KC1E
Casein kinase I isoform epsilon

1

1

High-throughput

0.618

High

889163

RBM25
RNA-binding protein 25

1

4

High-throughput

0.618

High

897910

CDK9
Cyclin-dependent kinase 9

1

3

High-throughput

0.618

High

978628

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.618

High

1051276

KPCZ
Protein kinase C zeta type

1

1

High-throughput

0.618

High

1083409

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

2

High-throughput

0.618

High

1109178

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

5

High-throughput

0.618

High

1127031

RBM39
RNA-binding protein 39

1

5

High-throughput

0.618

High

1144422

NONO
Non-POU domain-containing octamer-binding protein

1

3

High-throughput

0.618

High

1148527

SF3B4
Splicing factor 3B subunit 4

1

2

High-throughput

0.618

High

1160218

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

5

High-throughput

0.618

High

1329058

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

4

High-throughput

0.618

High

1336741

RB15B
Putative RNA-binding protein 15B

1

1

High-throughput

0.618

High

1356384

PSPC1
Paraspeckle component 1

1

3

High-throughput

0.618

High

1356387

REQU
Zinc finger protein ubi-d4

1

3

High-throughput

0.618

High

1356388

KAT6A
Histone acetyltransferase KAT6A

1

2

High-throughput

0.618

High

1356389

CELF1
CUGBP Elav-like family member 1

1

1

High-throughput

0.618

High

1356394

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

2

High-throughput

0.618

High

1356414

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.618

High

1356415

TBK1
Serine/threonine-protein kinase TBK1

1

4

High-throughput

0.618

High

1152415

DLG2
Disks large homolog 2

2

1

High-throughput

0.606

High

1239633

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

0

High-throughput

0.602

High

228326

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.586

High

967875

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.586

High

1152560

ELAV1
ELAV-like protein 1

1

0

High-throughput

0.586

High

1349045

R3GEF
Guanine nucleotide exchange factor for Rab-3A

2

0

High-throughput

0.585

High

1356420

LC7L2
Putative RNA-binding protein Luc7-like 2

2

0

High-throughput

0.585

High

1356421

AMMR1
Nuclear protein AMMECR1

2

0

High-throughput

0.585

High

1356422

ORC6
Origin recognition complex subunit 6

2

0

High-throughput

0.585

High

238926

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

2

5

High-throughput

0.584

High

242395

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

260206

BRD4
Bromodomain-containing protein 4

2

4

High-throughput

0.584

High

346108

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

3

High-throughput

0.584

High

372673

MYC
Myc proto-oncogene protein

2

8

High-throughput

0.584

High

386016

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

6

High-throughput

0.584

High

904963

MECP2
Methyl-CpG-binding protein 2

2

3

High-throughput

0.584

High

980039

H4
Histone H4

2

1

High-throughput

0.584

High

685278

PAX6
Paired box protein Pax-6

2

0

High-throughput

0.580

High

1145294

RNPS1
RNA-binding protein with serine-rich domain 1

1

6

High-throughput

0.575

High

1209434

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.575

High

1353095

ARH40
Rho guanine nucleotide exchange factor 40

2

2

High-throughput

0.571

High

302909

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

2

5

High-throughput

0.558

High

907169

SUOX
Sulfite oxidase, mitochondrial

1

0

High-throughput

0.557

High

164029

NDC80
Kinetochore protein NDC80 homolog

1

1

High-throughput

0.536

High

251630

CCNT1
Cyclin-T1

1

3

High-throughput

0.536

High

325004

HEXI1
Protein HEXIM1

1

2

High-throughput

0.536

High

659268

SP100
Nuclear autoantigen Sp-100

1

8

High-throughput

0.536

High

1356392

TMA16
Translation machinery-associated protein 16

1

1

High-throughput

0.536

High

139572

PESC
Pescadillo homolog

1

0

High-throughput

0.513

High

219985

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

1356382

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

1356416

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.513

High

1311252

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

4

High-throughput

0.508

High

1136291

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.489

High

1254135

CAN12
Calpain-12

1

1

High-throughput

0.489

High

1326847

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.489

High

1332389

TTC29
Tetratricopeptide repeat protein 29

1

1

High-throughput

0.489

High

1356396

SMAD5
Mothers against decapentaplegic homolog 5

1

0

High-throughput

0.486

High

129778

CBX4
E3 SUMO-protein ligase CBX4

1

3

High-throughput

0.479

High

191016

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

4

High-throughput

0.479

High

212288

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

1

High-throughput

0.479

High

252259

CCNT2
Cyclin-T2

1

4

High-throughput

0.479

High

280746

PR40A
Pre-mRNA-processing factor 40 homolog A

1

7

High-throughput

0.479

High

315806

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

318519

TOX4
TOX high mobility group box family member 4

1

7

High-throughput

0.479

High

325946

UBR5
E3 ubiquitin-protein ligase UBR5

1

4

High-throughput

0.479

High

447254

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

476764

RSSA
Small ribosomal subunit protein uS2

1

4

High-throughput

0.479

High

542127

TOP1
DNA topoisomerase 1

1

4

High-throughput

0.479

High

558285

XRCC6
X-ray repair cross-complementing protein 6

1

2

High-throughput

0.479

High

589248

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

634548

LMNB1
Lamin-B1

1

6

High-throughput

0.479

High

684326

DDX6
Probable ATP-dependent RNA helicase DDX6

1

3

High-throughput

0.479

High

696033

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

768732

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

776224

SOX6
Transcription factor SOX-6

1

4

High-throughput

0.479

High

831120

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

943395

H2BFS
Histone H2B type F-S

1

2

High-throughput

0.479

High

970832

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

980950

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

987135

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

2

High-throughput

0.479

High

987425

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

High-throughput

0.479

High

992623

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

High-throughput

0.479

High

995716

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

1058548

CKAP4
Cytoskeleton-associated protein 4

1

7

High-throughput

0.479

High

1067533

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

1113824

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1124667

SRC8
Src substrate cortactin

1

3

High-throughput

0.479

High

1126628

GRB7
Growth factor receptor-bound protein 7

1

3

Small-scale

0.479

High

1128067

DHX8
ATP-dependent RNA helicase DHX8

1

5

High-throughput

0.479

High

1156791

E2F4
Transcription factor E2F4

1

5

High-throughput

0.479

High

1213073

RHG21
Rho GTPase-activating protein 21

1

2

High-throughput

0.479

High

1218382

ARHGG
Rho guanine nucleotide exchange factor 16

1

7

High-throughput

0.479

High

1248045

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

1

High-throughput

0.479

High

1250019

WDR82
WD repeat-containing protein 82

1

10

High-throughput

0.479

High

1258888

H32
Histone H3.2

1

4

High-throughput

0.479

High

1271751

MEPCE
7SK snRNA methylphosphate capping enzyme

1

3

High-throughput

0.479

High

1313288

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1314324

SLX4
Structure-specific endonuclease subunit SLX4

1

4

High-throughput

0.479

High

1356383

ATX2L
Ataxin-2-like protein

1

3

High-throughput

0.479

High

1356385

TOPB1
DNA topoisomerase 2-binding protein 1

1

4

High-throughput

0.479

High

1356391

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1356400

DDX23
Probable ATP-dependent RNA helicase DDX23

1

3

High-throughput

0.479

High

1356404

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

1356405

ANLN
Anillin

1

2

High-throughput

0.479

High

1356406

ARHG4
Rho guanine nucleotide exchange factor 4

1

4

High-throughput

0.479

High

1356407

DCA13
DDB1- and CUL4-associated factor 13

1

3

High-throughput

0.479

High

1356408

DDX56
Probable ATP-dependent RNA helicase DDX56

1

4

High-throughput

0.479

High

1356410

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1356411

ITSN2
Intersectin-2

1

10

High-throughput

0.479

High

1356412

GMIP
GEM-interacting protein

1

3

High-throughput

0.479

High

1356413

NXF1
Nuclear RNA export factor 1

1

1

High-throughput

0.479

High

1356419

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

1

High-throughput

0.479

High

1356424

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

1

High-throughput

0.479

High

156537

UBFD1
Ubiquitin domain-containing protein UBFD1

1

0

High-throughput

0.458

High

502448

H2A1
Histone H2A type 1

1

0

High-throughput

0.458

High

552655

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.458

High

675598

TYY1
Transcriptional repressor protein YY1

1

0

High-throughput

0.458

High

800004

COIL
Coilin

1

0

High-throughput

0.458

High

809748

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.458

High

833002

ETV6
Transcription factor ETV6

1

0

High-throughput

0.458

High

871985

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

0

High-throughput

0.458

High

935577

MFAP1
Microfibrillar-associated protein 1

1

0

High-throughput

0.458

High

1205075

FA76B
Protein FAM76B

1

0

High-throughput

0.458

High

1241275

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.458

High

1277869

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

1294096

DDX42
ATP-dependent RNA helicase DDX42

1

0

High-throughput

0.458

High

1332824

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.458

High

1356395

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.458

High

1356397

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1356399

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.458

High

1356409

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

0

High-throughput

0.458

High

1356418

CC14A
Dual specificity protein phosphatase CDC14A

1

0

High-throughput

0.458

High

1356423

SPIN1
Spindlin-1

1

0

High-throughput

0.458

High

1198609

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.445

High

1340179

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

1

High-throughput

0.445

High

1356386

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

5

High-throughput

0.445

High

412317

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

1116267

PTC1
Protein patched homolog 1

1

1

Small-scale

0.437

High

1254799

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.437

High

1311203

RHG12
Rho GTPase-activating protein 12

1

4

High-throughput

0.437

High

1356393

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

1356398

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.437

High

1356401

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

1356403

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

1356417

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

High-throughput

0.437

High

1013314

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

1331778

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

359700

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.249

Low

720515

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.249

Low

1332874

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

87513

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

1273884

T2R42
Taste receptor type 2 member 42

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025