Interactor 1: CPSF5 (O43809)
Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit)
Gene: NUDT21

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.985

The method score is based on:

Property Details
Experiments 28514442, 32296183, 24981860, 33961781, 35271311, 39358380, 16189514, 26496610, 28524877, 21295486, 35177536, 22960638, unassigned1304
Identification Methods affinity chromatography technology, two hybrid, cross-linking study, molecular sieving, x-ray crystallography, ion exchange chromatography, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, two hybrid prey pooling approach and 3 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains NUDIX_2~RRM_1
Common GO terms GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 9 others

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Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 227
Hs

1 551
+ Mm
+ Hs
+ Dm
+ Ce
+ Ce
+ Dm

Service provided by Combinatics, Japan

Last updated: 11Aug2025