Protein: CPSF6
Cleavage and polyadenylation specificity factor subunit 6

Gene: CPSF6
Organism: Drosophila melanogaster
Interactions: 100
UniProt ID: Q9VSH4

Gene Ontology (top 5):
GO:0000381 - regulation of alternative mRNA splicing, via spliceosome
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
GO:0110104 - mRNA alternative polyadenylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1485605

CDK8
Cyclin-dependent kinase 8

3

9

Small-scale

0.853

High

889902

DOA
Serine/threonine-protein kinase Doa

1

7

Small-scale

0.724

High

1485604

Q9VSY2
Cleavage and polyadenylation specificity factor subunit 5

2

6

High-throughput

0.693

High

1440698

LAR4
La-related protein Larp4B

2

17

High-throughput

0.659

High

1463972

NCBP2
Nuclear cap-binding protein subunit 2

1

18

High-throughput

0.656

High

674056

BRM
ATP-dependent helicase brm

3

20

Small-scale

0.633

High

1171917

Q24090
GH08712p

3

7

Small-scale

0.633

High

1472290

Q9VE52
Cleavage stimulation factor 64 kD subunit

1

17

Small-scale

0.618

High

561848

MODU
DNA-binding protein modulo

1

15

High-throughput

0.575

High

1174672

U2AF2
Splicing factor U2AF 50 kDa subunit

1

15

High-throughput

0.575

High

1267556

NITO
RNA-binding protein spenito

1

14

High-throughput

0.575

High

1343914

Q8SXP8
TAR DNA-binding protein 43

1

18

High-throughput

0.575

High

1375055

U2AF1
Splicing factor U2af 38 kDa subunit

1

1

High-throughput

0.575

High

1464258

Q9V3T8
LD32469p

1

15

High-throughput

0.575

High

1485611

Q9VYD8
RE47308p

1

16

High-throughput

0.575

High

900671

DSH
Segment polarity protein dishevelled

2

3

High-throughput

0.571

High

1019299

MED20
Mediator of RNA polymerase II transcription subunit 20

2

1

High-throughput

0.571

High

1269631

MED13
Mediator of RNA polymerase II transcription subunit 13

2

1

High-throughput

0.571

High

1303628

OSA
Trithorax group protein osa

2

20

High-throughput

0.571

High

1321575

MED6
Mediator of RNA polymerase II transcription subunit 6

2

2

High-throughput

0.571

High

1377797

EBI
F-box-like/WD repeat-containing protein ebi

2

13

High-throughput

0.571

High

1472611

MED17
Mediator of RNA polymerase II transcription subunit 17

2

3

High-throughput

0.571

High

1473442

Q9VF03
Brahma associated protein 155 kDa

2

19

High-throughput

0.571

High

1480267

Q9VL29
GEO11246p1

2

1

High-throughput

0.571

High

1482737

MED27
Mediator of RNA polymerase II transcription subunit 27

2

1

High-throughput

0.571

High

1485336

MED4
Mediator of RNA polymerase II transcription subunit 4

2

2

High-throughput

0.571

High

1485570

MED24
Mediator of RNA polymerase II transcription subunit 24

2

1

High-throughput

0.571

High

1485609

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.571

High

1485612

BAP60
Brahma-associated protein of 60 kDa

2

15

High-throughput

0.571

High

1485616

MED30
Mediator of RNA polymerase II transcription subunit 30

2

1

High-throughput

0.571

High

1485625

MED18
Mediator of RNA polymerase II transcription subunit 18

2

1

High-throughput

0.571

High

1320953

Q8MQJ7
Autophagy-related 1, isoform B

1

2

Small-scale

0.553

High

1484666

Q9VR61
non-specific serine/threonine protein kinase

1

9

High-throughput

0.553

High

1306440

INDRA
Zinc finger protein indra

2

0

High-throughput

0.547

High

53598

A1Z813
Secretory 24AB, isoform A

2

14

High-throughput

0.521

High

58509

MED8
Mediator of RNA polymerase II transcription subunit 8

2

1

High-throughput

0.521

High

1267069

MED29
Mediator of RNA polymerase II transcription subunit 29

2

1

High-throughput

0.521

High

1321520

ENC
Protein encore

2

7

High-throughput

0.521

High

1346440

MESD
LDLR chaperone boca

2

1

High-throughput

0.521

High

1378939

Q960F7
SD03629p

2

9

High-throughput

0.521

High

1427998

MED10
Mediator of RNA polymerase II transcription subunit 10

2

1

High-throughput

0.521

High

1471837

MED25
Mediator of RNA polymerase II transcription subunit 25

2

16

High-throughput

0.521

High

1482719

Q9VNF8
Protein transport protein SEC23

2

14

High-throughput

0.521

High

1485606

Q9VUB7
PAX-interacting protein 1

2

12

High-throughput

0.521

High

1485615

Q9W0L7
ubiquitinyl hydrolase 1

2

9

High-throughput

0.521

High

1485617

MED14
Mediator of RNA polymerase II transcription subunit 14

2

16

High-throughput

0.521

High

1485618

MED23
Mediator of RNA polymerase II transcription subunit 23

2

2

High-throughput

0.521

High

1069270

Q0E8G6
Cleavage and polyadenylation specificity factor subunit 5

1

6

High-throughput

0.514

High

1484725

PNO1
RNA-binding protein pno1

1

1

High-throughput

0.508

High

57001

A1ZAK9
P-element somatic inhibitor, isoform A

1

20

High-throughput

0.479

High

118614

M9NF08
ZAP3, isoform D

1

2

High-throughput

0.479

High

1181165

Q32KD4
Protein argonaute-1

1

12

High-throughput

0.479

High

1192915

YAP1
Transcriptional coactivator yorkie

1

20

High-throughput

0.479

High

1267792

Q7KMQ6
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

High-throughput

0.479

High

1269698

Q7KU78
RNA helicase

1

11

High-throughput

0.479

High

1484617

Q9VR42
Serine/threonine-protein kinase RIO3

1

5

High-throughput

0.479

High

1485626

MED15
Mediator of RNA polymerase II transcription subunit 15

1

19

High-throughput

0.479

High

1481770

Q9VMH8
GEO07746p1

1

1

High-throughput

0.464

High

56957

A1ZAK7
LD35640p

1

20

High-throughput

0.445

High

197483

O18353
CHIP

1

1

High-throughput

0.445

High

1069937

Q0E996
Eukaryotic translation initiation factor 4 gamma 2

1

8

High-throughput

0.445

High

1302895

MED31
Mediator of RNA polymerase II transcription subunit 31

1

1

High-throughput

0.445

High

1409397

Q9BIW6
Brahma-associated protein 111kD

1

20

High-throughput

0.445

High

1472585

Q9VEB9
Sequence-specific single-stranded DNA-binding protein, isoform A

1

13

High-throughput

0.445

High

1477070

Q9VI14
GH12404p

1

17

High-throughput

0.445

High

1483011

MED1
Mediator of RNA polymerase II transcription subunit 1

1

2

High-throughput

0.445

High

1485607

LUC7L
Putative RNA-binding protein Alsin2

1

4

High-throughput

0.445

High

1485621

Q9W2Y5
YLP motif-containing protein 1

1

3

High-throughput

0.445

High

1485623

Q9W3G1
Uncharacterized protein, isoform A

1

20

High-throughput

0.445

High

1485624

Q9XZ21
Something that sticks like glue, isoform A

1

20

High-throughput

0.445

High

1270066

Q7KVF3
Uncharacterized protein

1

1

High-throughput

0.439

High

871897

GAP1
GTPase-activating protein

1

8

High-throughput

0.437

High

1047201

KELC
Ring canal kelch protein [Cleaved into: Kelch short protein]

1

4

Small-scale

0.437

High

1485620

Q9W2S2
Autophagy-related 8a, isoform A

1

17

Small-scale

0.437

High

1465340

MED22
Mediator of RNA polymerase II transcription subunit 22

1

0

High-throughput

0.426

High

1468157

SLBP
Histone RNA hairpin-binding protein

1

0

High-throughput

0.426

High

1343589

Q8SX59
LD42296p

1

1

High-throughput

0.417

High

1203053

Q5BIL9
SD21168p

1

1

High-throughput

0.407

High

1263903

Q7K012
Brahma associated protein 55kD

1

20

High-throughput

0.407

High

1346029

ENA
Protein enabled

1

14

High-throughput

0.407

High

1378342

Q95TT5
LD24616p

1

17

High-throughput

0.407

High

1378362

Q95TU2
LD23187p

1

18

High-throughput

0.407

High

1481781

Q9VMI5
CG9135 protein

1

2

High-throughput

0.407

High

1484287

Q9VQK5
LD24714p

1

20

High-throughput

0.407

High

1485506

Q9VSD3
AT11025p

1

4

High-throughput

0.407

High

1485610

MED12
Mediator of RNA polymerase II transcription subunit 12

1

20

High-throughput

0.407

High

1261426

Q7JQT8
LD41464p

2

0

High-throughput

0.298

High

1345937

Q8T4A8
AT07769p

2

0

High-throughput

0.298

High

1428107

MED7
Mediator of RNA polymerase II transcription subunit 7

2

0

High-throughput

0.298

High

1485619

MED16
Mediator of RNA polymerase II transcription subunit 16

2

0

High-throughput

0.298

High

57175

PTRO
Patronin

1

0

High-throughput

0.265

Low

1476399

CDPF1
Cysteine-rich DPF motif domain-containing protein 1

1

0

High-throughput

0.265

Low

1485614

Q9VYZ8
GEO08286p1

1

0

High-throughput

0.249

Low

828143

PNUT
Protein peanut

1

0

High-throughput

0.232

Low

1031662

UMPS
Uridine 5'-monophosphate synthase

1

0

High-throughput

0.232

Low

1473850

Q9VFF2
FI01402p

1

0

High-throughput

0.232

Low

1477698

NESD
Protein nessun dorma

1

0

High-throughput

0.232

Low

1485608

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.232

Low

1485613

Q9VYW4
ATP-binding cassette sub-family F member 1

1

0

High-throughput

0.232

Low

1485622

FRDA
Frataxin homolog, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025