HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PASK (Q96RG2)
PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1)
Gene: PASK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 1323
+	Hs
		227208 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KPCE_HUMAN (777-1318): 3.16e-125: 407: 18.91
+	Hs
		226638 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT2_HUMAN (897-1310): 5.61e-125: 397: 20.75
+	Hs
		226750 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KPCI_HUMAN (843-1321): 6.68e-122: 393: 19.37
+	Hs
		226637 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT1_HUMAN (897-1313): 2.45e-121: 387: 19.95
+	Hs
		226582 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK3_HUMAN (990-1272): 4.07e-108: 360: 33.22
+	Hs
		682055 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		AKT1_HUMAN (897-1313): 2.45e-121: 387: 19.95
+	Hs
		474936 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT2_HUMAN (897-1310): 5.61e-125: 397: 20.75
+	Sc
		419769 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		SNF1_YEAST (979-1290): 2.53e-119: 387: 24.84
+	Hs
		474935 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT1_HUMAN (897-1313): 2.45e-121: 387: 19.95
+	Hs
		227863 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK2_HUMAN (989-1251): 2.4e-37: 154: 36.43
+	Hs
		228811 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNRK_HUMAN (992-1251): 9.74e-35: 145: 33.58
+	At
		1091641 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN10_ARATH (998-1287): 3.22e-126: 402: 29.20
+	Hs
		475450 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KPCI_HUMAN (843-1321): 6.68e-122: 393: 19.37
+	At
		955189 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN11_ARATH (998-1287): 1.7e-123: 394: 28.86
+	Hs
		475390 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AKT1_HUMAN (897-1313): 2.45e-121: 387: 19.95
+	Sc
		477168 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PSK1_YEAST (999-1251): 1.1e-48: 192: 38.08