Protein: FGFR2
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)

Gene: FGFR2
Organism: Homo sapiens
Interactions: 225
UniProt ID: P21802

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001525 - angiogenesis
GO:0001657 - ureteric bud development
GO:0001701 - in utero embryonic development
GO:0001837 - epithelial to mesenchymal transition

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

426937

FGF1
Fibroblast growth factor 1

13

20

Small-scale

0.981

High

478445

FGF2
Fibroblast growth factor 2

13

20

Small-scale

0.981

High

640745

FGF7
Fibroblast growth factor 7

8

20

Small-scale

0.967

High

641114

FGFR2
Fibroblast growth factor receptor 2

6

17

Small-scale

0.946

High

618973

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

4

20

Small-scale

0.922

High

641152

GRB2
Growth factor receptor-bound protein 2

4

20

Small-scale

0.906

High

641141

KS6A3
Ribosomal protein S6 kinase alpha-3

4

20

High-throughput

0.906

High

193063

FGF10
Fibroblast growth factor 10

4

20

Small-scale

0.874

High

541338

FGFR1
Fibroblast growth factor receptor 1

3

17

High-throughput

0.871

High

641115

FGFR3
Fibroblast growth factor receptor 3

3

18

Small-scale

0.870

High

641281

KDIS
Kinase D-interacting substrate of 220 kDa

3

20

High-throughput

0.861

High

641178

KS6A2
Ribosomal protein S6 kinase alpha-2

2

20

High-throughput

0.811

High

641125

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

Small-scale

0.793

High

641163

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

20

High-throughput

0.793

High

641179

KS6A1
Ribosomal protein S6 kinase alpha-1

2

20

High-throughput

0.789

High

641184

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

8

High-throughput

0.778

High

641122

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.754

High

641126

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.747

High

546963

FGF3
Fibroblast growth factor 3

2

20

Small-scale

0.738

High

532199

FGF6
Fibroblast growth factor 6

2

20

Small-scale

0.727

High

641127

FGF9
Fibroblast growth factor 9

2

20

Small-scale

0.727

High

641146

FCGRN
IgG receptor FcRn large subunit p51

2

19

High-throughput

0.726

High

641234

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

2

16

High-throughput

0.726

High

641161

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

High-throughput

0.698

High

641177

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

High-throughput

0.698

High

641242

RSLAB
Ras-like protein family member 10B

1

20

High-throughput

0.698

High

641252

RHBT2
Rho-related BTB domain-containing protein 2

1

20

High-throughput

0.698

High

641265

S10AE
Protein S100-A14

1

4

High-throughput

0.698

High

641117

KALM
Anosmin-1

1

18

Small-scale

0.692

High

641131

RYK
Tyrosine-protein kinase RYK

1

17

High-throughput

0.691

High

641156

CD83
CD83 antigen

1

1

High-throughput

0.691

High

252658

TSN3
Tetraspanin-3

3

7

High-throughput

0.667

High

641276

S53A1
Solute carrier family 53 member 1

3

2

High-throughput

0.667

High

557090

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.665

High

472382

FGF4
Fibroblast growth factor 4

1

20

Small-scale

0.647

High

641176

NECT1
Nectin-1

1

20

Small-scale

0.647

High

409262

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

16

High-throughput

0.646

High

641182

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.646

High

641220

FRS2
Fibroblast growth factor receptor substrate 2

3

20

Small-scale

0.640

High

175594

SR140
U2 snRNP-associated SURP motif-containing protein

2

8

High-throughput

0.628

High

370004

TIMP1
Metalloproteinase inhibitor 1

2

3

High-throughput

0.628

High

591221

CD44
CD44 antigen

2

5

High-throughput

0.628

High

641130

SDC2
Syndecan-2

2

4

High-throughput

0.628

High

641164

GOGA3
Golgin subfamily A member 3

2

11

High-throughput

0.628

High

641172

UBE4A
Ubiquitin conjugation factor E4 A

2

5

High-throughput

0.628

High

641175

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

2

20

High-throughput

0.628

High

641185

CC50B
Cell cycle control protein 50B

2

6

High-throughput

0.628

High

641198

F171B
Protein FAM171B

2

20

High-throughput

0.628

High

641207

CHERP
Calcium homeostasis endoplasmic reticulum protein

2

7

High-throughput

0.628

High

641210

SIGL1
SIGLEC family-like protein 1

2

1

High-throughput

0.628

High

641218

RAE1E
Retinoic acid early transcript 1E

2

20

High-throughput

0.628

High

641231

MRAP2
Melanocortin-2 receptor accessory protein 2

2

2

High-throughput

0.628

High

641243

PKP4
Plakophilin-4

2

20

High-throughput

0.628

High

641245

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

2

1

High-throughput

0.628

High

641255

BC11A
BCL11 transcription factor A

2

2

High-throughput

0.628

High

410615

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.621

High

641191

ATD3B
ATPase family AAA domain-containing protein 3B

2

13

High-throughput

0.618

High

136290

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.618

High

296435

STAM2
Signal transducing adapter molecule 2

1

20

High-throughput

0.618

High

440363

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.618

High

463329

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.618

High

641124

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

641129

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.618

High

641133

STAT3
Signal transducer and activator of transcription 3

1

19

Small-scale

0.618

High

641136

STA5A
Signal transducer and activator of transcription 5A

1

19

Small-scale

0.618

High

641139

DYN2
Dynamin-2

1

12

High-throughput

0.618

High

641140

STA5B
Signal transducer and activator of transcription 5B

1

19

Small-scale

0.618

High

641143

EPHA4
Ephrin type-A receptor 4

1

20

Small-scale

0.618

High

641147

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

High-throughput

0.618

High

641159

DYST
Dystonin

1

17

High-throughput

0.618

High

641196

SCYL2
SCY1-like protein 2

1

20

High-throughput

0.618

High

641206

KLOTB
Beta-klotho

1

11

Small-scale

0.618

High

641241

ERBIN
Erbin

1

20

High-throughput

0.618

High

641256

TARA
TRIO and F-actin-binding protein

1

20

High-throughput

0.618

High

641273

ITSN2
Intersectin-2

1

20

High-throughput

0.618

High

641285

DYN3
Dynamin-3

1

13

High-throughput

0.618

High

641223

IP6K1
Inositol hexakisphosphate kinase 1

2

0

High-throughput

0.602

High

641253

CE295
Centrosomal protein of 295 kDa

2

0

High-throughput

0.602

High

641153

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.575

High

641162

VMAT2
Synaptic vesicular amine transporter

1

5

High-throughput

0.575

High

641183

VACHT
Vesicular acetylcholine transporter

1

4

High-throughput

0.575

High

641238

MF14A
Hippocampus abundant transcript 1 protein

1

6

High-throughput

0.575

High

641192

IFFO2
Intermediate filament family orphan 2

2

2

High-throughput

0.574

High

641224

UBXN4
UBX domain-containing protein 4

2

4

High-throughput

0.574

High

641233

CC120
Coiled-coil domain-containing protein 120

2

1

High-throughput

0.574

High

641236

SNX22
Sorting nexin-22

2

1

High-throughput

0.574

High

641237

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

2

20

High-throughput

0.574

High

641289

SNX24
Sorting nexin-24

2

20

High-throughput

0.574

High

641200

MPRIP
Myosin phosphatase Rho-interacting protein

1

20

High-throughput

0.553

High

641227

STAM1
Signal transducing adapter molecule 1

1

20

High-throughput

0.553

High

181682

CTDSL
CTD small phosphatase-like protein

1

8

High-throughput

0.541

High

322130

GLCE
D-glucuronyl C5-epimerase

1

1

High-throughput

0.541

High

484832

HXC6
Homeobox protein Hox-C6

1

2

High-throughput

0.541

High

641132

PPM1A
Protein phosphatase 1A

1

7

High-throughput

0.541

High

641169

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

20

High-throughput

0.541

High

641235

PDLI2
PDZ and LIM domain protein 2

1

15

High-throughput

0.541

High

641248

MTA3
Metastasis-associated protein MTA3

1

6

High-throughput

0.541

High

641250

BEX2
Protein BEX2

1

3

High-throughput

0.541

High

641254

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

8

High-throughput

0.541

High

641260

BEX1
Protein BEX1

1

3

High-throughput

0.541

High

641277

ERRFI
ERBB receptor feedback inhibitor 1

1

10

High-throughput

0.541

High

641137

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

16

High-throughput

0.536

High

602860

INAR1
Interferon alpha/beta receptor 1

1

17

High-throughput

0.536

High

641118

IL32
Interleukin-32

1

1

High-throughput

0.536

High

641120

IL3RA
Interleukin-3 receptor subunit alpha

1

19

High-throughput

0.536

High

641128

SDC4
Syndecan-4

1

4

High-throughput

0.536

High

641151

ARF6
ADP-ribosylation factor 6

1

19

High-throughput

0.536

High

641211

RN149
E3 ubiquitin-protein ligase RNF149

1

9

High-throughput

0.536

High

641217

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

3

High-throughput

0.536

High

641225

SL9A6
Sodium/hydrogen exchanger 6

1

4

High-throughput

0.536

High

641261

CRLF2
Cytokine receptor-like factor 2

1

15

High-throughput

0.536

High

641279

FBX2
F-box only protein 2

1

10

High-throughput

0.536

High

641282

CLC4A
C-type lectin domain family 4 member A

1

10

High-throughput

0.536

High

641284

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

8

High-throughput

0.536

High

169434

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

20

Small-scale

0.533

High

240134

FGF17
Fibroblast growth factor 17

1

20

Small-scale

0.527

High

551528

FGF5
Fibroblast growth factor 5

1

20

Small-scale

0.527

High

641144

FGF8
Fibroblast growth factor 8

1

20

Small-scale

0.527

High

404598

TFF1
Trefoil factor 1

1

0

High-throughput

0.518

High

641209

TM130
Transmembrane protein 130

1

0

High-throughput

0.513

High

641212

CS018
Uncharacterized protein C19orf18

1

0

High-throughput

0.513

High

421499

A4
Amyloid-beta precursor protein

1

11

High-throughput

0.501

High

641123

CCN2
CCN family member 2

1

1

Small-scale

0.501

High

641290

FBX7
F-box only protein 7

1

5

High-throughput

0.501

High

228443

LANC1
Glutathione S-transferase LANCL1

1

4

High-throughput

0.500

High

284063

SRS10
Serine/arginine-rich splicing factor 10

1

8

High-throughput

0.500

High

285589

BAF
Barrier-to-autointegration factor

1

8

High-throughput

0.500

High

557860

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.500

High

616256

RCC1
Regulator of chromosome condensation

1

4

High-throughput

0.500

High

633836

MPRD
Cation-dependent mannose-6-phosphate receptor

1

3

High-throughput

0.500

High

641119

HMGB2
High mobility group protein B2

1

14

High-throughput

0.500

High

641121

CALX
Calnexin

1

20

High-throughput

0.500

High

641154

PRKDC
DNA-dependent protein kinase catalytic subunit

1

14

High-throughput

0.500

High

641155

TFAM
Transcription factor A, mitochondrial

1

9

High-throughput

0.500

High

641157

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

19

High-throughput

0.500

High

641165

LG3BP
Galectin-3-binding protein

1

10

High-throughput

0.500

High

641166

SSRP1
FACT complex subunit SSRP1

1

9

High-throughput

0.500

High

641168

TRA2A
Transformer-2 protein homolog alpha

1

12

High-throughput

0.500

High

641170

DX39B
Spliceosome RNA helicase DDX39B

1

9

High-throughput

0.500

High

641180

SAFB1
Scaffold attachment factor B1

1

20

High-throughput

0.500

High

641190

UBR4
E3 ubiquitin-protein ligase UBR4

1

3

High-throughput

0.500

High

641216

ZSC18
Zinc finger and SCAN domain-containing protein 18

1

5

High-throughput

0.500

High

641239

RBM14
RNA-binding protein 14

1

20

High-throughput

0.500

High

641246

AIF1L
Allograft inflammatory factor 1-like

1

2

High-throughput

0.500

High

641247

NTPCR
Cancer-related nucleoside-triphosphatase

1

10

High-throughput

0.500

High

641251

PDIP3
Polymerase delta-interacting protein 3

1

6

High-throughput

0.500

High

641270

FANCI
Fanconi anemia group I protein

1

11

High-throughput

0.500

High

641271

ATD3A
ATPase family AAA domain-containing protein 3A

1

18

High-throughput

0.500

High

641280

MRT4
mRNA turnover protein 4 homolog

1

7

High-throughput

0.500

High

641291

SP16H
FACT complex subunit SPT16

1

4

High-throughput

0.500

High

641292

RBM8A
RNA-binding protein 8A

1

8

High-throughput

0.500

High

326658

DUS14
Dual specificity protein phosphatase 14

1

20

High-throughput

0.494

High

641288

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.479

High

126994

APBB1
Amyloid beta precursor protein binding family B member 1

1

5

High-throughput

0.479

High

299935

CBPD
Carboxypeptidase D

1

10

High-throughput

0.479

High

324524

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

338421

SC24B
Protein transport protein Sec24B

1

20

High-throughput

0.479

High

442871

PRGR
Progesterone receptor

1

6

Small-scale

0.479

High

473660

ITA5
Integrin alpha-5

1

5

Small-scale

0.479

High

548420

MPRI
Cation-independent mannose-6-phosphate receptor

1

8

High-throughput

0.479

High

560307

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.479

High

641116

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.479

High

641134

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

11

High-throughput

0.479

High

641138

MMP14
Matrix metalloproteinase-14

1

4

Small-scale

0.479

High

641142

AGFG1
Arf-GAP domain and FG repeat-containing protein 1

1

20

High-throughput

0.479

High

641148

ABCE1
ATP-binding cassette sub-family E member 1

1

8

High-throughput

0.479

High

641158

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

12

High-throughput

0.479

High

641160

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

1

Small-scale

0.479

High

641171

DSG2
Desmoglein-2

1

20

High-throughput

0.479

High

641173

FLOT2
Flotillin-2

1

14

High-throughput

0.479

High

641174

EPN4
Clathrin interactor 1

1

19

High-throughput

0.479

High

641181

TRIPB
Thyroid receptor-interacting protein 11

1

20

High-throughput

0.479

High

641186

GRDN
Girdin

1

20

High-throughput

0.479

High

641187

LARP7
La-related protein 7

1

20

High-throughput

0.479

High

641189

ZN326
DBIRD complex subunit ZNF326

1

3

High-throughput

0.479

High

641193

WAC2A
WASH complex subunit 2A

1

3

High-throughput

0.479

High

641194

STEA3
Metalloreductase STEAP3

1

4

High-throughput

0.479

High

641199

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

9

High-throughput

0.479

High

641201

GRIN3
G protein-regulated inducer of neurite outgrowth 3

1

14

High-throughput

0.479

High

641214

VANG1
Vang-like protein 1

1

12

High-throughput

0.479

High

641215

GOGA5
Golgin subfamily A member 5

1

12

High-throughput

0.479

High

641219

DLG5
Disks large homolog 5

1

20

High-throughput

0.479

High

641221

SMAP2
Stromal membrane-associated protein 2

1

20

High-throughput

0.479

High

641226

US6NL
USP6 N-terminal-like protein

1

20

High-throughput

0.479

High

641228

APBB2
Amyloid beta precursor protein binding family B member 2

1

5

High-throughput

0.479

High

641232

DDX27
Probable ATP-dependent RNA helicase DDX27

1

20

High-throughput

0.479

High

641240

MTMR9
Myotubularin-related protein 9

1

17

High-throughput

0.479

High

641249

RFIP5
Rab11 family-interacting protein 5

1

13

High-throughput

0.479

High

641257

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

13

High-throughput

0.479

High

641258

GCP60
Golgi resident protein GCP60

1

16

High-throughput

0.479

High

641259

WDR26
WD repeat-containing protein 26

1

14

High-throughput

0.479

High

641262

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

16

Small-scale

0.479

High

641266

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.479

High

641267

JPH1
Junctophilin-1

1

9

High-throughput

0.479

High

641268

WDR6
tRNA

1

20

High-throughput

0.479

High

641272

GGA3
ADP-ribosylation factor-binding protein GGA3

1

20

High-throughput

0.479

High

641278

GGA2
ADP-ribosylation factor-binding protein GGA2

1

20

High-throughput

0.479

High

641283

SYNRG
Synergin gamma

1

1

High-throughput

0.479

High

641286

MTMR6
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6

1

17

High-throughput

0.479

High

641287

TPPC8
Trafficking protein particle complex subunit 8

1

3

High-throughput

0.479

High

641149

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.458

High

641205

LAP4B
Lysosomal-associated transmembrane protein 4B

1

0

Small-scale

0.458

High

641275

UNC79
Protein unc-79 homolog

1

0

High-throughput

0.458

High

641135

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

14

High-throughput

0.457

High

641145

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

9

High-throughput

0.457

High

641150

COPZ1
Coatomer subunit zeta-1

1

5

High-throughput

0.457

High

641167

SRSF9
Serine/arginine-rich splicing factor 9

1

12

High-throughput

0.457

High

641202

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

3

High-throughput

0.457

High

641204

MON2
Protein MON2 homolog

1

8

High-throughput

0.457

High

641188

S22A6
Solute carrier family 22 member 6

1

5

High-throughput

0.445

High

641197

NPAL3
NIPA-like protein 3

1

1

High-throughput

0.445

High

641213

ZNT7
Zinc transporter 7

1

4

High-throughput

0.445

High

641263

ANKH
Mineralization regulator ANKH

1

2

High-throughput

0.445

High

336068

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

20

High-throughput

0.437

High

641203

ZFY16
Zinc finger FYVE domain-containing protein 16

1

20

High-throughput

0.437

High

641208

M21D2
Nucleotidyltransferase MB21D2

1

10

High-throughput

0.437

High

641229

SEH1
Nucleoporin SEH1

1

10

High-throughput

0.437

High

641230

OTUB1
Ubiquitin thioesterase OTUB1

1

1

Small-scale

0.437

High

641244

CDCA3
Cell division cycle-associated protein 3

1

13

High-throughput

0.437

High

641264

Q9HCK3
KIAA1569 protein

1

3

High-throughput

0.437

High

641274

F135A
Protein FAM135A

1

7

High-throughput

0.437

High

641195

CH074
Uncharacterized protein C8orf74

3

0

High-throughput

0.347

High

641269

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.261

Low

641222

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025