HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: M3K3 (Q99759)
Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)
Gene: MAP3K3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 626
+	Hs
		229115 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Hs
		227243 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KPCD_HUMAN (22-625): 8.67e-139: 421: 17.86
+	Hs
		475158 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		M3K3_HUMAN (1-626): 0: 606: 100.00
+	Hs
		226638 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT2_HUMAN (247-622): 1.1e-127: 386: 22.40
+	Hs
		226637 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67
+	Hs
		227338 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAK2_HUMAN (123-624): 8.76e-126: 383: 23.91
+	Hs
		1306392 Q9UFQ0_HUMAN (1-153): 6.63e-50: 172: 19.48		M3K3_HUMAN (1-626): 0: 606: 100.00
+	Hs
		476266 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		M3K3_HUMAN (1-626): 0: 606: 100.00
+	Hs
		475248 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Hs
		476603 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Hs
		682055 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67
+	Hs
		474936 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT2_HUMAN (247-622): 1.1e-127: 386: 22.40
+	Hs
		474935 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67
+	At
		1091641 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN10_ARATH (361-623): 3.5e-131: 396: 31.70
+	At
		955189 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN11_ARATH (361-624): 3.46e-129: 391: 31.58
+	Hs
		475390 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67
+	Hs
		1028427 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		M3K1_HUMAN (362-619): 9.22e-53: 197: 44.03
+	Hs
		475017 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		M3K1_HUMAN (362-619): 9.22e-53: 197: 44.03
+	Hs
		475703 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		M3K1_HUMAN (362-619): 9.22e-53: 197: 44.03
+	Hs
		476663 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		M3K4_HUMAN (341-624): 3.69e-51: 193: 39.10