Protein: SEC12
Guanine nucleotide-exchange factor SEC12 (Prolactin regulatory element-binding protein)

Gene: SEC12, PREB
Organism: Homo sapiens
Interactions: 150
UniProt ID: Q9HCU5

Gene Ontology (top 5):
GO:0003400 - regulation of COPII vesicle coating
GO:0003677 - DNA binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

255226

ICOSL
ICOS ligand

2

3

High-throughput

0.811

High

1016031

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

18

High-throughput

0.691

High

890439

SC61B
Protein transport protein Sec61 subunit beta

3

2

High-throughput

0.656

High

328395

S1PR4
Sphingosine 1-phosphate receptor 4

1

4

High-throughput

0.618

High

714696

CNR2
Cannabinoid receptor 2

1

3

Small-scale

0.618

High

1335589

LPAR2
Lysophosphatidic acid receptor 2

1

3

High-throughput

0.618

High

682027

AKT1
RAC-alpha serine/threonine-protein kinase

1

9

High-throughput

0.618

High

682213

AKT2
RAC-beta serine/threonine-protein kinase

1

11

High-throughput

0.618

High

828025

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

10

High-throughput

0.618

High

654803

CALX
Calnexin

2

4

High-throughput

0.611

High

228771

PRKN
E3 ubiquitin-protein ligase parkin

2

19

High-throughput

0.584

High

350576

RASK
GTPase KRas

2

7

High-throughput

0.584

High

370485

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

283038

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

20

High-throughput

0.553

High

940574

CXAR
Coxsackievirus and adenovirus receptor

1

1

High-throughput

0.553

High

1171810

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.553

High

1331348

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.553

High

125924

CDC7
Cell division cycle 7-related protein kinase

1

16

High-throughput

0.536

High

513762

CP19A
Aromatase

1

2

High-throughput

0.536

High

833342

TMEDA
Transmembrane emp24 domain-containing protein 10

1

6

High-throughput

0.536

High

1117499

ANO6
Anoctamin-6

1

1

High-throughput

0.536

High

1283290

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

1292719

ZDH12
Palmitoyltransferase ZDHHC12

1

1

High-throughput

0.536

High

1336535

PCDB3
Protocadherin beta-3

1

2

High-throughput

0.536

High

1336537

SRPRB
Signal recognition particle receptor subunit beta

1

7

High-throughput

0.536

High

1317897

GTPB4
GTP-binding protein 4

1

10

High-throughput

0.515

High

1336529

SEC63
Translocation protein SEC63 homolog

1

6

High-throughput

0.515

High

968926

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

1053822

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1239964

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.513

High

1336536

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

0

High-throughput

0.513

High

1336538

TX264
Testis-expressed protein 264

1

0

High-throughput

0.513

High

656384

DMB
HLA class II histocompatibility antigen, DM beta chain

1

1

High-throughput

0.489

High

1103898

ANO4
Anoctamin-4

1

1

High-throughput

0.489

High

1336524

GPC5B
G-protein coupled receptor family C group 5 member B

1

2

High-throughput

0.489

High

48520

ESYT2
Extended synaptotagmin-2

1

4

High-throughput

0.479

High

120655

RHOD
Rho-related GTP-binding protein RhoD

1

12

High-throughput

0.479

High

163992

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

4

High-throughput

0.479

High

348939

RASN
GTPase NRas

1

8

High-throughput

0.479

High

364446

TFR1
Transferrin receptor protein 1

1

3

High-throughput

0.479

High

390546

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

3

High-throughput

0.479

High

391188

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.479

High

432279

HS90A
Heat shock protein HSP 90-alpha

1

12

High-throughput

0.479

High

436520

RHOC
Rho-related GTP-binding protein RhoC

1

11

High-throughput

0.479

High

438547

HS90B
Heat shock protein HSP 90-beta

1

13

High-throughput

0.479

High

455896

PARP1
Poly [ADP-ribose] polymerase 1

1

7

High-throughput

0.479

High

514726

CP2C9
Cytochrome P450 2C9

1

2

High-throughput

0.479

High

545631

RAC2
Ras-related C3 botulinum toxin substrate 2

1

11

High-throughput

0.479

High

553778

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

591689

RAB3B
Ras-related protein Rab-3B

1

3

High-throughput

0.479

High

595426

LMNB1
Lamin-B1

1

5

High-throughput

0.479

High

648894

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

652316

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

719623

MERL
Merlin

1

1

High-throughput

0.479

High

724281

MSX2
Homeobox protein MSX-2

1

1

High-throughput

0.479

High

726426

BASI
Basigin

1

1

High-throughput

0.479

High

780140

CCNF
Cyclin-F

1

7

High-throughput

0.479

High

786143

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.479

High

825561

LMAN1
Protein ERGIC-53

1

1

High-throughput

0.479

High

839152

EMD
Emerin

1

2

High-throughput

0.479

High

845751

RAB9A
Ras-related protein Rab-9A

1

6

High-throughput

0.479

High

847666

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.479

High

894462

CDC42
Cell division control protein 42 homolog

1

11

High-throughput

0.479

High

900932

RHOA
Transforming protein RhoA

1

12

High-throughput

0.479

High

917968

H4
Histone H4

1

9

High-throughput

0.479

High

941457

RNF4
E3 ubiquitin-protein ligase RNF4

1

6

High-throughput

0.479

High

951360

RHOG
Rho-related GTP-binding protein RhoG

1

11

High-throughput

0.479

High

990692

CKAP4
Cytoskeleton-associated protein 4

1

14

High-throughput

0.479

High

999111

EP300
Histone acetyltransferase p300

1

17

High-throughput

0.479

High

1017809

STX4
Syntaxin-4

1

2

High-throughput

0.479

High

1040269

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.479

High

1053201

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

9

High-throughput

0.479

High

1156720

TECT3
Tectonic-3

1

1

High-throughput

0.479

High

1162122

RHDF2
Inactive rhomboid protein 2

1

4

High-throughput

0.479

High

1165969

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1198691

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

8

High-throughput

0.479

High

1220668

MIRO2
Mitochondrial Rho GTPase 2

1

17

High-throughput

0.479

High

1243400

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.479

High

1256053

RHBL4
Rhomboid-related protein 4

1

4

High-throughput

0.479

High

1269677

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1284090

LRC59
Leucine-rich repeat-containing protein 59

1

6

High-throughput

0.479

High

1294027

DDRGK
DDRGK domain-containing protein 1

1

6

High-throughput

0.479

High

1296080

DNJC1
DnaJ homolog subfamily C member 1

1

9

High-throughput

0.479

High

1300787

PANX1
Pannexin-1

1

1

High-throughput

0.479

High

1311406

ESYT1
Extended synaptotagmin-1

1

4

High-throughput

0.479

High

1313062

DERL1
Derlin-1

1

5

High-throughput

0.479

High

1319257

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.479

High

1328861

DJC25
DnaJ homolog subfamily C member 25

1

5

High-throughput

0.479

High

1329287

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

3

High-throughput

0.479

High

1332639

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1336519

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.479

High

1336520

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.479

High

1336522

ELOV5
Very long chain fatty acid elongase 5

1

2

High-throughput

0.479

High

1336528

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1336530

UBQL2
Ubiquilin-2

1

3

High-throughput

0.479

High

1336531

AMFR
E3 ubiquitin-protein ligase AMFR

1

10

High-throughput

0.479

High

1336532

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.479

High

795293

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

815824

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

0

Small-scale

0.458

High

1126134

MKS3
Meckelin

1

0

High-throughput

0.458

High

1199614

LBN
Limbin

1

0

High-throughput

0.458

High

1303169

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1303581

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1333576

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1336518

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1336523

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1336525

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1336527

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

1241628

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.445

High

1299182

MIA2
Melanoma inhibitory activity protein 2

1

18

High-throughput

0.445

High

1336534

ITM2B
Integral membrane protein 2B

1

3

High-throughput

0.445

High

178799

STX7
Syntaxin-7

1

2

High-throughput

0.437

High

352263

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

545043

AMPN
Aminopeptidase N

1

1

High-throughput

0.437

High

573924

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

4

High-throughput

0.437

High

592025

RAB4A
Ras-related protein Rab-4A

1

4

High-throughput

0.437

High

670227

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.437

High

721508

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

844751

RAB5C
Ras-related protein Rab-5C

1

4

High-throughput

0.437

High

845265

RAB7A
Ras-related protein Rab-7a

1

6

High-throughput

0.437

High

961832

REEP5
Receptor expression-enhancing protein 5

1

2

High-throughput

0.437

High

1070408

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.437

High

1162528

Q6PK50
Heat shock protein HSP 90-beta

1

13

High-throughput

0.437

High

1198181

TM11B
Transmembrane protease serine 11B

1

1

High-throughput

0.437

High

1203862

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

1204340

DYR2
Dihydrofolate reductase 2, mitochondrial

1

1

High-throughput

0.437

High

1220990

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

1

High-throughput

0.437

High

1230384

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.437

High

1239743

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.437

High

1240310

DHB11
Estradiol 17-beta-dehydrogenase 11

1

4

High-throughput

0.437

High

1263909

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.437

High

1284243

CLUA1
Clusterin-associated protein 1

1

1

High-throughput

0.437

High

1290069

RNF31
E3 ubiquitin-protein ligase RNF31

1

11

High-throughput

0.437

High

1292871

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1298761

SCLT1
Sodium channel and clathrin linker 1

1

18

High-throughput

0.437

High

1336533

NUDC
Nuclear migration protein nudC

1

10

High-throughput

0.437

High

1135

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

1084199

OCLN
Occludin

2

0

High-throughput

0.328

High

245422

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

362161

ACHA
Acetylcholine receptor subunit alpha

1

0

High-throughput

0.279

Low

1125130

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

1134300

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

1219020

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1302914

KCNKG
Potassium channel subfamily K member 16

1

0

High-throughput

0.279

Low

1332355

TM231
Transmembrane protein 231

1

0

High-throughput

0.279

Low

1101306

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1244709

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

1283948

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1336521

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1336526

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024