HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: TBA1C (Q9BQE3)
Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]
Gene: TUBA1C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	25959826, 35509820, 35987950, 35256949, 24244333
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 449
+	Hs
		227133 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBA4A_HUMAN (1-448): 0: 724: 96.21
+	Hs
		227132 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBA1B_HUMAN (1-439): 0: 717: 99.09
+	Hs
		227858 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBA1A_HUMAN (1-439): 0: 715: 99.09
+	Hs
		226284 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		228902 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBA8_HUMAN (1-439): 0: 698: 90.66
+	Hs
		227134 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		228556 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBB2B_HUMAN (1-440): 0: 697: 40.23
+	Hs
		1348225 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		TBA8_HUMAN (1-439): 0: 698: 90.66
+	Hs
		312567 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		TBA1B_HUMAN (1-439): 0: 717: 99.09
+	At
		1013212 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TBA4_ARATH (1-435): 0: 811: 86.21
+	At
		668104 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TBA6_ARATH (1-435): 0: 810: 85.98
+	Hs
		312449 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		312568 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		475606 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TBA4A_HUMAN (1-448): 0: 724: 96.21
+	Hs
		475961 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TBA1A_HUMAN (1-439): 0: 715: 99.09