HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SYT11 (Q9BT88)
Synaptotagmin-11 (Synaptotagmin XI) (SytXI)
Gene: SYT11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 0.60 0.639

The method score is based on:

Property Details
Experiments 12925569, 32814053
Identification Methods two hybrid, affinity chromatography technology, pull down, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0007612 - learning
GO:0014059 - regulation of dopamine secretion
GO:0014069 - postsynaptic density
GO:0031625 - ubiquitin protein ligase binding
GO:0043005 - neuron projection
and 3 others

more...
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 465
Hs

1 431
+ Rn
+ Mm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024