HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: TBB6 (Q9BUF5)
Tubulin beta-6 chain (Tubulin beta class V)
Gene: TUBB6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 446
+	Hs
		227375 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBB3_HUMAN (1-446): 0: 727: 92.38
+	Hs
		226284 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBB5_HUMAN (1-429): 0: 719: 92.54
+	Hs
		227134 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBB4B_HUMAN (1-427): 0: 717: 92.74
+	Hs
		228556 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBB2B_HUMAN (1-430): 0: 717: 92.79
+	Hs
		227408 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBB2A_HUMAN (1-430): 0: 714: 92.56
+	Hs
		226233 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBB4A_HUMAN (1-427): 0: 713: 93.44
+	Hs
		227629 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBB8_HUMAN (1-427): 0: 703: 87.12
+	Hs
		1037286 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		TBB3_HUMAN (1-446): 0: 727: 92.38
+	Hs
		1312799 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		TBB6_HUMAN (1-446): 0: 720: 100.00
+	Ce
		853147 Q9XUS3_CAEEL (6-464): 2.19e-70: 230: 25.44		TBB2_CAEEL (1-441): 0: 716: 86.40
+	Dm
		1098189 Q9VT94_DROME (194-464): 9.94e-67: 224: 21.46		TBB1_DROME (1-429): 0: 716: 92.08
+	Hs
		312449 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		TBB5_HUMAN (1-429): 0: 719: 92.54
+	Hs
		1037267 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		TBB3_HUMAN (1-446): 0: 727: 92.38
+	Hs
		312568 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		TBB4B_HUMAN (1-427): 0: 717: 92.74