Protein: ISK2
Serine protease inhibitor Kazal-type 2 (Acrosin-trypsin inhibitor) (Epididymis tissue protein Li 172) (HUSI-II)

Gene: ISK2, SPINK2
Organism: Homo sapiens
Interactions: 31
UniProt ID: P20155

Gene Ontology (top 5):
GO:0001669 - acrosomal vesicle
GO:0001675 - acrosome assembly
GO:0004866 - endopeptidase inhibitor activity
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

628598

KLK4
Kallikrein-4

1

0

Small-scale

0.657

High

628590

RSPRY
RING finger and SPRY domain-containing protein 1

2

0

High-throughput

0.602

High

228545

STRN
Striatin

2

2

High-throughput

0.574

High

281880

MPPB
Mitochondrial-processing peptidase subunit beta

2

2

High-throughput

0.574

High

575109

IDE
Insulin-degrading enzyme

2

3

High-throughput

0.574

High

628578

MPPA
Mitochondrial-processing peptidase subunit alpha

2

2

High-throughput

0.574

High

628587

UBR1
E3 ubiquitin-protein ligase UBR1

2

1

High-throughput

0.574

High

628588

UBR2
E3 ubiquitin-protein ligase UBR2

2

1

High-throughput

0.574

High

628584

ATL4
ADAMTS-like protein 4

1

0

High-throughput

0.549

High

628586

NT2NA
Notch homolog 2 N-terminal-like protein A

1

0

High-throughput

0.549

High

628573

KRA59
Keratin-associated protein 5-9

1

1

High-throughput

0.523

High

628574

GRN
Progranulin

1

0

High-throughput

0.493

High

628579

STRN3
Striatin-3

1

2

High-throughput

0.489

High

628581

PREP
Presequence protease, mitochondrial

1

3

High-throughput

0.489

High

628594

STRN4
Striatin-4

1

2

High-throughput

0.489

High

628575

GFRP
GTP cyclohydrolase 1 feedback regulatory protein

2

0

High-throughput

0.328

High

628582

STRP1
Striatin-interacting protein 1

2

0

High-throughput

0.328

High

628583

DCA15
DDB1- and CUL4-associated factor 15

2

0

High-throughput

0.328

High

628589

NUDT8
Mitochondrial coenzyme A diphosphatase NUDT8

2

0

High-throughput

0.328

High

628591

ATP5S
ATP synthase subunit s, mitochondrial

2

0

High-throughput

0.328

High

628592

MIPEP
Mitochondrial intermediate peptidase

2

0

High-throughput

0.328

High

628595

CT2NL
CTTNBP2 N-terminal-like protein

2

0

High-throughput

0.328

High

628596

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

2

0

High-throughput

0.328

High

628597

PHOCN
MOB-like protein phocein

2

0

High-throughput

0.328

High

628580

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

0

High-throughput

0.300

High

628585

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.279

Low

628593

PRDC1
Phosphoribosyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

628599

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.279

Low

301334

WFS1
Wolframin

1

0

High-throughput

0.268

Low

628577

KR103
Keratin-associated protein 10-3

1

0

High-throughput

0.251

Low

628576

TIG1
Retinoic acid receptor responder protein 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025