HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: MYLK2 (Q9H1R3)
Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18)
Gene: MYLK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0010628 - positive regulation of gene expression
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 596
+	Hs
		227554 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MYLK_HUMAN (7-593): 4.13e-134: 432: 30.33
+	Hs
		226638 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT2_HUMAN (172-594): 1.37e-136: 408: 21.09
+	Hs
		226637 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT1_HUMAN (172-588): 3.1e-135: 404: 21.43
+	Hs
		229082 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KCC2A_HUMAN (271-596): 2.76e-134: 402: 32.33
+	Hs
		227381 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KCC2D_HUMAN (280-596): 5.43e-133: 399: 30.53
+	Hs
		682055 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		AKT1_HUMAN (172-588): 3.1e-135: 404: 21.43
+	Hs
		200073 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DAPK3_HUMAN (271-566): 4.44e-67: 227: 40.06
+	Hs
		228210 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TITIN_HUMAN (289-591): 2.8e-56: 207: 35.97
+	Hs
		474936 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT2_HUMAN (172-594): 1.37e-136: 408: 21.09
+	Hs
		474935 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT1_HUMAN (172-588): 3.1e-135: 404: 21.43
+	At
		1091642 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPKB_ARATH (261-580): 5.18e-138: 412: 29.23
+	At
		1091641 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN10_ARATH (270-592): 9.35e-136: 407: 28.75
+	At
		1091676 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPK3_ARATH (285-580): 8.03e-136: 407: 33.22
+	Hs
		475390 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AKT1_HUMAN (172-588): 3.1e-135: 404: 21.43
+	Hs
		475723 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KCC2D_HUMAN (280-596): 5.43e-133: 399: 30.53
+	Hs
		475511 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DAPK1_HUMAN (271-540): 5.04e-64: 230: 42.09