Protein: COPA
Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (Retrieval from endoplasmic reticulum protein 1) (Secretory protein 22) (Suppressor of osmo-sensitivity 1)

Gene: COPA, COP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 228
UniProt ID: P53622

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005198 - structural molecule activity
GO:0006886 - intracellular protein transport
GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006890 - retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

825664

COPE
Coatomer subunit epsilon

13

1

Small-scale

0.985

High

836070

COPB2
Coatomer subunit beta'

12

16

Small-scale

0.978

High

836012

COPB
Coatomer subunit beta

10

6

Small-scale

0.974

High

732178

COPG
Coatomer subunit gamma

9

10

Small-scale

0.970

High

922098

COPA
Coatomer subunit alpha

3

15

Small-scale

0.829

High

536150

ARF1
ADP-ribosylation factor 1

2

12

Small-scale

0.754

High

850738

COPD
Coatomer subunit delta

9

4

Small-scale

0.752

High

921488

COPZ
Coatomer subunit zeta

5

5

High-throughput

0.714

High

801700

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

5

5

Small-scale

0.703

High

793963

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

18

High-throughput

0.691

High

922141

DUF1
DUB-associated factor 1

1

19

High-throughput

0.691

High

849651

EMP47
Protein EMP47

3

1

Small-scale

0.656

High

922117

ERV41
ER-derived vesicles protein ERV41

3

7

High-throughput

0.656

High

922099

DSL1
Protein transport protein DSL1

3

1

Small-scale

0.640

High

922110

GCN5
Histone acetyltransferase GCN5

1

16

High-throughput

0.618

High

754648

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

4

2

Small-scale

0.618

High

792664

AP2A
AP-2 complex subunit alpha

1

6

High-throughput

0.618

High

922124

VPS74
Vacuolar protein sorting-associated protein 74

2

7

Small-scale

0.602

High

679921

CDC48
Cell division control protein 48

2

6

High-throughput

0.594

High

652936

BET1
Protein transport protein BET1

2

4

Small-scale

0.584

High

813915

ERV46
ER-derived vesicles protein ERV46

2

7

High-throughput

0.584

High

626835

HSP60
Heat shock protein 60, mitochondrial

1

16

High-throughput

0.578

High

922103

ACT
Actin

1

6

High-throughput

0.578

High

922102

TMEDA
Endoplasmic reticulum vesicle protein 25

2

13

Small-scale

0.571

High

784000

RM10
Large ribosomal subunit protein uL15m

2

1

High-throughput

0.567

High

383818

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.553

High

444583

DED1
ATP-dependent RNA helicase DED1

1

5

High-throughput

0.553

High

601095

RL8A
Large ribosomal subunit protein eL8A

1

5

High-throughput

0.553

High

677046

GID7
GID complex subunit 7

1

16

High-throughput

0.553

High

763954

SPT10
Protein SPT10

1

1

High-throughput

0.553

High

779302

CENPA
Histone H3-like centromeric protein CSE4

1

7

High-throughput

0.553

High

792169

GBLP
Small ribosomal subunit protein RACK1

1

19

High-throughput

0.553

High

812093

DHH1
ATP-dependent RNA helicase DHH1

1

9

High-throughput

0.553

High

874444

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.553

High

918932

PESC
Pescadillo homolog

1

1

High-throughput

0.553

High

922138

SEC39
Protein transport protein SEC39

1

1

Small-scale

0.552

High

393109

HSP82
ATP-dependent molecular chaperone HSP82

2

9

High-throughput

0.543

High

922113

RUVB1
RuvB-like protein 1

2

6

High-throughput

0.543

High

365670

PGK
Phosphoglycerate kinase

2

1

High-throughput

0.537

High

670972

SIS1
Protein SIS1

2

11

High-throughput

0.537

High

509665

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

11

Small-scale

0.534

High

599055

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

2

3

High-throughput

0.533

High

699421

CIN8
Kinesin-like protein CIN8

2

11

High-throughput

0.533

High

802299

RS20
Small ribosomal subunit protein uS10

2

1

High-throughput

0.533

High

850123

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

5

High-throughput

0.533

High

545748

SSB1
Ribosome-associated molecular chaperone SSB1

2

14

High-throughput

0.521

High

727216

HS104
Heat shock protein 104

2

4

High-throughput

0.521

High

754173

MSN2
Zinc finger protein MSN2

2

4

High-throughput

0.521

High

823012

ATAD2
ATPase histone chaperone YTA7

2

8

High-throughput

0.521

High

871851

SEC16
COPII coat assembly protein SEC16

1

0

Small-scale

0.519

High

823093

VPS27
Vacuolar protein sorting-associated protein 27

1

6

Small-scale

0.515

High

419823

H2A2
Histone H2A.2

1

4

High-throughput

0.514

High

810735

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.514

High

811001

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.514

High

893320

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

7

High-throughput

0.514

High

922119

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

2

High-throughput

0.514

High

863217

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.513

High

524709

HSP71
Heat shock protein SSA1

2

14

High-throughput

0.504

High

819382

SSB2
Ribosome-associated molecular chaperone SSB2

2

14

High-throughput

0.504

High

780087

MNN4
Mannosyltransferase regulator 4

1

14

Small-scale

0.501

High

811551

MNN1
Alpha-1,3-mannosyltransferase MNN1

1

1

Small-scale

0.501

High

863613

MNN11
Probable alpha-1,6-mannosyltransferase MNN11

1

1

Small-scale

0.501

High

917990

MST27
Multicopy suppressor of SEC21 protein 27

1

1

Small-scale

0.501

High

368349

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

2

High-throughput

0.489

High

452752

ADR1
Regulatory protein ADR1

1

3

High-throughput

0.489

High

479993

PRTB
Cerevisin

1

2

High-throughput

0.489

High

678985

NOT1
General negative regulator of transcription subunit 1

1

1

High-throughput

0.489

High

748883

SWE1
Mitosis inhibitor protein kinase SWE1

1

7

High-throughput

0.489

High

757842

PP2C3
Protein phosphatase 2C homolog 3

1

2

High-throughput

0.489

High

793094

ATPG
ATP synthase subunit gamma, mitochondrial

1

2

High-throughput

0.489

High

825464

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

8

High-throughput

0.489

High

922115

KU80
ATP-dependent DNA helicase II subunit 2

1

2

High-throughput

0.489

High

922127

PRP11
Pre-mRNA-splicing factor PRP11

1

1

High-throughput

0.489

High

439532

PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

1

High-throughput

0.479

High

646259

SEC22
Protein transport protein SEC22

1

2

Small-scale

0.479

High

676863

RER1
Protein RER1

1

3

Small-scale

0.479

High

735855

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

2

High-throughput

0.479

High

744893

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

4

Small-scale

0.479

High

745377

EMP24
Endosomal protein P24B

1

11

Small-scale

0.479

High

747970

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

795471

ATG8
Autophagy-related protein 8

1

3

High-throughput

0.479

High

803090

GOSR1
Golgi SNAP receptor complex member 1

1

1

High-throughput

0.479

High

815520

RSP5
E3 ubiquitin-protein ligase RSP5

1

9

Small-scale

0.479

High

877871

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.479

High

922128

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

602580

PHO85
Cyclin-dependent protein kinase PHO85

1

3

High-throughput

0.470

High

604553

PHO81
Phosphate system positive regulatory protein PHO81

1

3

High-throughput

0.470

High

818027

LSM4
LSM complex subunit LSM4

1

2

High-throughput

0.464

High

676549

VATL1
V-type proton ATPase subunit c

1

0

High-throughput

0.458

High

518089

SSBP1
Single-stranded nucleic acid-binding protein

1

6

High-throughput

0.457

High

728656

OCH1
Initiation-specific alpha-1,6-mannosyltransferase

1

1

Small-scale

0.457

High

794052

KTR3
Probable mannosyltransferase KTR3

1

1

Small-scale

0.457

High

367788

ENO1
Enolase 1

1

3

High-throughput

0.457

High

405120

LEU3
3-isopropylmalate dehydrogenase

1

8

High-throughput

0.457

High

456436

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

4

High-throughput

0.457

High

481705

HSP73
Heat shock protein SSA3

1

14

High-throughput

0.457

High

486498

TBA3
Tubulin alpha-3 chain

1

12

High-throughput

0.457

High

531368

METK1
S-adenosylmethionine synthase 1

1

2

High-throughput

0.457

High

590688

HSP26
Heat shock protein 26

1

3

High-throughput

0.457

High

645759

HSP74
Heat shock protein SSA4

1

14

High-throughput

0.457

High

661671

MPCP
Mitochondrial phosphate carrier protein

1

6

High-throughput

0.457

High

734162

EF2
Elongation factor 2

1

4

High-throughput

0.457

High

760312

BMH2
Protein BMH2

1

4

High-throughput

0.457

High

802667

YHI0
Putative proline--tRNA ligase YHR020W

1

3

High-throughput

0.457

High

922136

HSP42
Heat shock protein 42

1

3

High-throughput

0.457

High

510694

HSP77
Import motor subunit, mitochondrial

1

14

High-throughput

0.445

High

922126

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

9

High-throughput

0.445

High

149881

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.437

High

359042

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

5

High-throughput

0.437

High

359308

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

5

High-throughput

0.437

High

410255

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

415114

ADT1
ADP,ATP carrier protein 1

1

4

High-throughput

0.437

High

430895

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

2

Small-scale

0.437

High

433764

RL26A
Large ribosomal subunit protein uL24A

1

4

High-throughput

0.437

High

435256

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.437

High

436084

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.437

High

442035

RS14A
Small ribosomal subunit protein uS11A

1

5

High-throughput

0.437

High

448771

SNF1
Carbon catabolite-derepressing protein kinase

1

4

Small-scale

0.437

High

454752

KAPR
cAMP-dependent protein kinase regulatory subunit

1

1

Small-scale

0.437

High

455184

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

503162

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

504336

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

512566

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.437

High

513135

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

514755

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.437

High

674750

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.437

High

689577

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

692597

NSR1
Nuclear localization sequence-binding protein

1

2

High-throughput

0.437

High

701478

IPYR2
Inorganic pyrophosphatase, mitochondrial

1

1

High-throughput

0.437

High

701553

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

6

High-throughput

0.437

High

707781

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

713287

MCM5
Minichromosome maintenance protein 5

1

1

High-throughput

0.437

High

727682

TPS2
Trehalose-phosphatase

1

3

High-throughput

0.437

High

735351

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

1

High-throughput

0.437

High

737753

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

5

High-throughput

0.437

High

737918

HOG1
Mitogen-activated protein kinase HOG1

1

4

High-throughput

0.437

High

738414

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.437

High

753501

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

763470

MDJ1
DnaJ homolog 1, mitochondrial

1

13

High-throughput

0.437

High

764133

SPT21
Protein SPT21

1

1

High-throughput

0.437

High

778458

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.437

High

782175

LAS1
Protein LAS1

1

1

Small-scale

0.437

High

782224

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

1

High-throughput

0.437

High

796607

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

8

High-throughput

0.437

High

797430

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

6

High-throughput

0.437

High

799669

TPS3
Trehalose synthase complex regulatory subunit TPS3

1

3

High-throughput

0.437

High

799690

TSL1
Trehalose synthase complex regulatory subunit TSL1

1

3

High-throughput

0.437

High

799759

IF5
Eukaryotic translation initiation factor 5

1

3

High-throughput

0.437

High

801787

KPR3
Ribose-phosphate pyrophosphokinase 3

1

1

High-throughput

0.437

High

803633

RPN1
26S proteasome regulatory subunit RPN1

1

3

High-throughput

0.437

High

806781

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.437

High

812527

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

815192

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.437

High

824759

MLP2
Protein MLP2

1

13

High-throughput

0.437

High

825114

AYR1
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase

1

7

High-throughput

0.437

High

826708

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

827565

RLP7
Ribosome biogenesis protein RLP7

1

5

High-throughput

0.437

High

829843

PHB1
Prohibitin-1

1

6

High-throughput

0.437

High

836817

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.437

High

844556

UTP10
U3 small nucleolar RNA-associated protein 10

1

3

High-throughput

0.437

High

849731

LAM5
Membrane-anchored lipid-binding protein LAM5

1

2

High-throughput

0.437

High

861041

RS10B
Small ribosomal subunit protein eS10B

1

4

High-throughput

0.437

High

916769

ERG25
C-4 methylsterol oxidase ERG25

1

1

High-throughput

0.437

High

916941

VID30
GID complex subunit 1

1

6

High-throughput

0.437

High

918310

RL26B
Large ribosomal subunit protein uL24B

1

4

High-throughput

0.437

High

922101

APJ1
J domain-containing protein APJ1

1

14

High-throughput

0.437

High

922105

NUM1
Nuclear migration protein NUM1

1

5

High-throughput

0.437

High

922106

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

3

High-throughput

0.437

High

922107

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

922108

ESP1
Separin

1

1

High-throughput

0.437

High

922109

TOM1
E3 ubiquitin-protein ligase TOM1

1

9

High-throughput

0.437

High

922111

SCS7
Ceramide very long chain fatty acid hydroxylase SCS7

1

1

High-throughput

0.437

High

922114

BUD22
Bud site selection protein 22

1

1

High-throughput

0.437

High

922116

MYO5
Myosin-5

1

3

High-throughput

0.437

High

922120

FAR8
Factor arrest protein 8

1

1

High-throughput

0.437

High

922122

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

922129

SGO1
Shugoshin

1

1

High-throughput

0.437

High

922130

ESA1
Histone acetyltransferase ESA1

1

4

Small-scale

0.437

High

922131

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

922134

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

2

Small-scale

0.437

High

922137

RUVB2
RuvB-like protein 2

1

6

High-throughput

0.437

High

922139

SMC6
Structural maintenance of chromosomes protein 6

1

3

High-throughput

0.437

High

922140

RS22B
Small ribosomal subunit protein uS8B

1

2

High-throughput

0.437

High

922123

KEI1
Inositol phosphorylceramide synthase regulatory subunit KEI1

1

0

Small-scale

0.426

High

527306

HSP72
Heat shock protein SSA2

1

14

High-throughput

0.407

High

597750

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

1

High-throughput

0.407

High

631976

SRP54
Signal recognition particle subunit SRP54

1

1

High-throughput

0.407

High

676219

MAS5
Mitochondrial protein import protein MAS5

1

14

High-throughput

0.407

High

742086

HSP7F
Heat shock protein homolog SSE1

1

16

High-throughput

0.407

High

752565

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.407

High

779562

LHS1
Heat shock protein 70 homolog LHS1

1

16

High-throughput

0.407

High

807251

SPT8
SAGA complex subunit SPT8

1

1

High-throughput

0.407

High

823278

JEM1
DnaJ-like chaperone JEM1

1

11

High-throughput

0.407

High

865951

DPH4
Diphthamide biosynthesis protein 4

1

8

High-throughput

0.407

High

915237

ACS2
Acetyl-coenzyme A synthetase 2

1

5

High-throughput

0.407

High

922100

JJJ1
J protein JJJ1

1

8

High-throughput

0.407

High

922121

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

18

High-throughput

0.407

High

917344

RRT6
Regulator of rDNA transcription protein 6

1

1

Small-scale

0.373

High

636938

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.279

Low

758511

SLD2
DNA replication regulator SLD2

1

0

High-throughput

0.279

Low

815006

SLN1
Osmosensing histidine protein kinase SLN1

1

0

High-throughput

0.279

Low

917769

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.279

Low

922133

SELO
Protein adenylyltransferase SelO, mitochondrial

1

0

High-throughput

0.279

Low

804638

SSF1
Ribosome biogenesis protein SSF1

1

0

High-throughput

0.269

Low

922125

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.269

Low

922132

PCL8
PHO85 cyclin-8

1

0

High-throughput

0.269

Low

454122

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.261

Low

823438

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

428026

PLMT
Phosphatidyl-N-methylethanolamine N-methyltransferase

1

0

High-throughput

0.249

Low

470721

MET3
Sulfate adenylyltransferase

1

0

High-throughput

0.249

Low

528851

RLA3
Large ribosomal subunit protein P1B

1

0

High-throughput

0.249

Low

697335

COQ8
Atypical kinase COQ8, mitochondrial

1

0

High-throughput

0.249

Low

734830

SRP21
Signal recognition particle subunit SRP21

1

0

High-throughput

0.249

Low

735087

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

740309

PAH1
Phosphatidic acid phosphohydrolase 1

1

0

High-throughput

0.249

Low

780788

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

797016

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

798104

OM14
Mitochondrial outer membrane protein OM14

1

0

High-throughput

0.249

Low

815373

RS26A
Small ribosomal subunit protein eS26A

1

0

High-throughput

0.249

Low

849830

BUD27
Bud site selection protein 27

1

0

High-throughput

0.249

Low

866118

STE24
CAAX prenyl protease 1

1

0

High-throughput

0.249

Low

873828

BUL1
Ubiquitin ligase-binding protein BUL1

1

0

High-throughput

0.249

Low

922104

CACM
Putative mitochondrial carnitine O-acetyltransferase

1

0

High-throughput

0.249

Low

922112

SRC1
Inner nuclear membrane protein SRC1

1

0

High-throughput

0.249

Low

922118

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.249

Low

922135

YVC1
Calcium channel YVC1

1

0

High-throughput

0.249

Low

922142

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025