HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: NB5R1 (Q9UHQ9)
NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) (Humb5R2) (NAD(P)H:quinone oxidoreductase type 3 polypeptide A2)
Gene: CYB5R1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35256949, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 305
+	Hs
		226191 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NB5R3_HUMAN (1-305): 1.65e-117: 342: 59.02
+	Hs
		226444 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NCPR_HUMAN (11-293): 2.03e-64: 216: 14.24
+	Hs
		228353 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		OXND1_HUMAN (55-302): 4.64e-30: 117: 16.92
+	Hs
		476530 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NB5R1_HUMAN (1-305): 1.26e-123: 357: 100.00
+	Hs
		335345 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NB5R3_HUMAN (1-305): 1.65e-117: 342: 59.02
+	Sc
		477254 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		NCB5R_YEAST (25-305): 7.1e-77: 238: 34.59
+	At
		502758 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		NIA2_ARATH (22-303): 1.83e-95: 303: 44.88
+	At
		1092441 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		NB5R1_ARATH (29-305): 1.26e-82: 252: 39.57