HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: COR1C (Q9ULV4)
Coronin-1C (Coronin-3) (hCRNN4)
Gene: CORO1C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001933 - negative regulation of protein phosphorylation
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 474
+	Hs
		228509 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		COR1B_HUMAN (2-472): 1.75e-120: 362: 72.14
+	Hs
		226631 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		COR1A_HUMAN (2-467): 2.74e-113: 343: 64.24
+	Hs
		228555 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KTNB1_HUMAN (18-459): 4.13e-80: 263: 13.14
+	Hs
		228315 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNR40_HUMAN (160-435): 1.36e-38: 145: 11.87
+	Hs
		227583 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RBBP7_HUMAN (14-341): 1.13e-35: 139: 18.94
+	Hs
		228248 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		COR2A_HUMAN (4-212): 5.87e-25: 109: 10.46
+	Hs
		227278 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RBBP4_HUMAN (129-345): 4.31e-24: 106: 15.39
+	Hs
		227004 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CORO7_HUMAN (2-203): 2.45e-23: 105: 12.22
+	Hs
		476284 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		COR1B_HUMAN (2-472): 1.75e-120: 362: 72.14
+	Hs
		227054 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR5_HUMAN (257-397): 3.67e-15: 78.4: 8.39
+	Hs
		1219356 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		SNR40_HUMAN (160-435): 1.36e-38: 145: 11.87
+	Hs
		312590 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		RBBP4_HUMAN (129-345): 4.31e-24: 106: 15.39
+	Sc
		477455 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		CORO_YEAST (2-228): 2.02e-24: 108: 12.16
+	Hs
		312684 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		WSB1_HUMAN (145-313): 6.42e-16: 81.6: 22.09
+	Hs
		476181 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SNR40_HUMAN (160-435): 1.36e-38: 145: 11.87
+	Hs
		475670 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RBBP4_HUMAN (129-345): 4.31e-24: 106: 15.39
+	Hs
		475563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WDR5_HUMAN (257-397): 3.67e-15: 78.4: 8.39