HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SRRM2 (Q9UQ35)
Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)
Gene: SRRM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	32929329, 35509820, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016607 - nuclear speck
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 2752
+	Hs
		226795 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MAP1B_HUMAN (15-1517): 8.71e-69: 261: 10.13
+	Hs
		227149 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MAP1A_HUMAN (170-2540): 2.1e-44: 181: 9.15
+	Hs
		228948 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STAR9_HUMAN (764-2750): 1.09e-41: 172: 13.94
+	Hs
		228669 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TARA_HUMAN (1540-2752): 1.5e-31: 138: 11.50
+	Hs
		228210 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TITIN_HUMAN (26-1299): 8.38e-20: 100: 7.11
+	Hs
		228104 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		BD1L1_HUMAN (16-2752): 1.77e-19: 99.2: 9.13
+	Hs
		226818 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRC2A_HUMAN (8-1230): 6.75e-14: 80.5: 10.65
+	Hs
		229228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCLO_HUMAN (17-2592): 3.11e-13: 78.6: 7.68
+	Hs
		229173 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRC2C_HUMAN (1360-2752): 9.55e-11: 70.1: 9.11
+	Hs
		228019 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AGRG4_HUMAN (260-1385): 9.17e-10: 67.1: 13.70
+	Hs
		228101 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KMT2C_HUMAN (1760-2747): 2.06e-09: 65.9: 9.01
+	Hs
		476234 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CIC_HUMAN (216-2751): 1.9e-62: 240: 8.98
+	Hs
		476412 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MUC5B_HUMAN (601-2752): 1.13e-58: 228: 9.90
+	Hs
		476121 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MUC16_HUMAN (111-2747): 6.13e-36: 153: 10.09
+	Hs
		152577 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KMT2D_HUMAN (10-501): 7.91e-09: 63.9: 11.75
+	At
		1092118 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q9LIE8_ARATH (2430-2751): 3.38e-09: 65.1: 12.01