HitPredict

Interactor 1: GBG7 (O60262)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Gene: GNG7

Interactor 2: GBB1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
Gene: GNB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.963

Property	Details
Experiments	28087732, 8636150, 19168127, 16301321, 33961781, 35271311, 12782285
Identification Methods	protein complementation assay, two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	G-gamma~WD40
Common GO terms	GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 68 Hs			1 340
+	Hs
		229238 GBG7_HUMAN (1-68): 1.22e-28: 98.6: 100.00		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		229245 GBG7_HUMAN (1-68): 1.22e-28: 98.6: 100.00		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Hs
		229235 GBG7_HUMAN (1-68): 1.22e-28: 98.6: 100.00		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Hs
		921761 GBG12_HUMAN (2-68): 1.99e-26: 93.2: 77.61		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		887097 GBG2_HUMAN (2-68): 5.03e-26: 92: 70.59		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		1334920 GBG12_HUMAN (2-68): 1.99e-26: 93.2: 77.61		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Hs
		921073 GBG12_HUMAN (2-68): 1.99e-26: 93.2: 77.61		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		921516 GBG3_HUMAN (1-68): 1.12e-25: 91.2: 60.87		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		560893 GBG12_HUMAN (2-68): 1.99e-26: 93.2: 77.61		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Hs
		887096 GBG2_HUMAN (2-68): 5.03e-26: 92: 70.59		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		887126 GBG2_HUMAN (2-68): 5.03e-26: 92: 70.59		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Bt
		920925 GBG2_BOVIN (2-68): 5.03e-26: 92: 70.59		GBB1_BOVIN (1-340): 7.02e-105: 312: 100.00
+	Mm
		921088 GBG2_MOUSE (2-68): 5.03e-26: 92: 70.59		GBB1_MOUSE (1-340): 7.02e-105: 312: 100.00
+	Hs
		920932 GBG3_HUMAN (1-68): 1.12e-25: 91.2: 60.87		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		929157 GBG3_HUMAN (1-68): 1.12e-25: 91.2: 60.87		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Hs
		560868 GBG2_HUMAN (2-68): 5.03e-26: 92: 70.59		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Hs
		560872 GBG3_HUMAN (1-68): 1.12e-25: 91.2: 60.87		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Hs
		154646 GBG7_HUMAN (1-68): 1.22e-28: 98.6: 100.00		GNB5_HUMAN (129-340): 1.35e-45: 161: 21.46
+	Hs
		154670 GBG2_HUMAN (2-68): 5.03e-26: 92: 70.59		GNB5_HUMAN (129-340): 1.35e-45: 161: 21.46
+	Hs
		154672 GBG3_HUMAN (1-68): 1.12e-25: 91.2: 60.87		GNB5_HUMAN (129-340): 1.35e-45: 161: 21.46