HitPredict

Interactor 1: SMCA5 (O60264)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H)
Gene: SMARCA5

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.909

Property	Details
Experiments	11691835, 29568061, 34079125, 36089195, 15616580
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization GO:0006334 - nucleosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1052 Hs			1 136
+	Hs
		229363 SMCA5_HUMAN (19-1052): 0: 1097: 100.00		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Mm
		935460 SMCA5_MOUSE (33-1052): 0: 1094: 98.33		H31_MOUSE (1-136): 2.8e-62: 188: 100.00
+	Mm
		952763 SMCA5_MOUSE (33-1052): 0: 1094: 98.33		H33_MOUSE (1-136): 2.73e-61: 186: 96.32
+	Mm
		952266 SMCA5_MOUSE (33-1052): 0: 1094: 98.33		H32_MOUSE (1-136): 6.5e-61: 185: 99.27
+	Hs
		229341 SMCA5_HUMAN (19-1052): 0: 1097: 100.00		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Hs
		658647 SMCA1_HUMAN (71-1030): 0: 1042: 85.29		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		658651 SMCA1_HUMAN (71-1030): 0: 1042: 85.29		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		658641 SMCA1_HUMAN (71-1030): 0: 1042: 85.29		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Sc
		902117 ISW2_YEAST (1-1052): 0: 848: 45.67		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Hs
		935016 CHD5_HUMAN (5-1050): 0: 809: 26.28		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		1086233 CHD5_HUMAN (5-1050): 0: 809: 26.28		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Mm
		56901 CHD5_MOUSE (5-1050): 0: 810: 26.45		H33_MOUSE (1-136): 2.73e-61: 186: 96.32
+	Hs
		934705 CHD3_HUMAN (8-1052): 0: 801: 26.23		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		935324 CHD7_HUMAN (9-1049): 0: 800: 25.86		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952302 CHD3_HUMAN (8-1052): 0: 801: 26.23		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		952670 CHD7_HUMAN (9-1049): 0: 800: 25.86		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Sc
		744893 ISW1_YEAST (2-1046): 0: 790: 43.78		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Hs
		934770 CHD4_HUMAN (14-945): 0: 769: 26.95		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		828213 CHD3_HUMAN (8-1052): 0: 801: 26.23		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Hs
		828410 CHD7_HUMAN (9-1049): 0: 800: 25.86		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00