HitPredict

Interactor 1: JIP4 (O60271)
C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1)
Gene: SPAG9

Interactor 2: MP2K2 (P36507)
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
Gene: MAP2K2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005078 - MAP-kinase scaffold activity GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1321 Hs			1 400
+	Hs
		229626 JIP4_HUMAN (1-1321): 0: 803: 100.00		KAPCG_HUMAN (32-368): 1.73e-122: 360: 21.63
+	Hs
		229642 JIP4_HUMAN (1-1321): 0: 803: 100.00		MP2K3_HUMAN (15-388): 8.33e-102: 307: 32.47
+	Hs
		229641 JIP4_HUMAN (1-1321): 0: 803: 100.00		MP2K4_HUMAN (2-396): 1.01e-100: 306: 32.52
+	Hs
		972271 JIP3_HUMAN (1-1321): 0: 731: 54.49		MP2K1_HUMAN (2-399): 2.32e-128: 376: 78.14
+	Mm
		682480 JIP3_MOUSE (1-1321): 0: 704: 55.14		MP2K1_MOUSE (2-399): 6.24e-128: 375: 78.14
+	Hs
		805489 JIP3_HUMAN (1-1321): 0: 731: 54.49		MP2K3_HUMAN (15-388): 8.33e-102: 307: 32.47
+	Hs
		801006 JIP3_HUMAN (1-1321): 0: 731: 54.49		MP2K4_HUMAN (2-396): 1.01e-100: 306: 32.52
+	Mm
		814033 JIP3_MOUSE (1-1321): 0: 704: 55.14		MP2K4_MOUSE (2-396): 1.64e-101: 308: 32.52
+	Hs
		153188 JIP3_HUMAN (1-1321): 0: 731: 54.49		MP2K7_HUMAN (39-383): 1.39e-58: 198: 34.82
+	Mm
		1208258 JIP3_MOUSE (1-1321): 0: 704: 55.14		MP2K7_MOUSE (39-383): 7.29e-57: 196: 34.82
+	Ce
		106072 JIP_CAEEL (16-1316): 2.02e-147: 479: 31.57		SEK1_CAEEL (58-376): 1.36e-57: 193: 36.17
+	Hs
		528359 MYH6_HUMAN (358-966): 2.92e-21: 103: 9.02		KAPCB_HUMAN (62-368): 2.15e-122: 359: 21.54
+	Hs
		610795 MYH2_HUMAN (365-1000): 1.6e-20: 101: 8.85		KAPCB_HUMAN (62-368): 2.15e-122: 359: 21.54
+	Hs
		528368 MYH6_HUMAN (358-966): 2.92e-21: 103: 9.02		CDK3_HUMAN (69-374): 1.36e-113: 335: 23.64
+	Hs
		960128 MYH2_HUMAN (365-1000): 1.6e-20: 101: 8.85		CDK3_HUMAN (69-374): 1.36e-113: 335: 23.64
+	Hs
		528369 MYH6_HUMAN (358-966): 2.92e-21: 103: 9.02		STK4_HUMAN (41-377): 2.43e-109: 331: 28.74
+	Hs
		1023137 MYH2_HUMAN (365-1000): 1.6e-20: 101: 8.85		STK4_HUMAN (41-377): 2.43e-109: 331: 28.74
+	Hs
		528371 MYH6_HUMAN (358-966): 2.92e-21: 103: 9.02		STK3_HUMAN (54-390): 1.33e-108: 329: 30.37
+	Hs
		1027452 MYH2_HUMAN (365-1000): 1.6e-20: 101: 8.85		STK3_HUMAN (54-390): 1.33e-108: 329: 30.37
+	Hs
		528363 MYH6_HUMAN (358-966): 2.92e-21: 103: 9.02		MP2K3_HUMAN (15-388): 8.33e-102: 307: 32.47