HitPredict

Interactor 1: KIF5C (O60282)
Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1)
Gene: KIF5C

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	32812023, 35063084
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005874 - microtubule GO:0008017 - microtubule binding GO:0043025 - neuronal cell body GO:1904115 - axon cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 957 Hs			1 758
+	Hs
		496931 KIF5A_HUMAN (2-956): 5.34e-140: 446: 74.45		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		111250 J3KNA1_HUMAN (120-956): 2.74e-121: 394: 71.69		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		2882 A0A0G2JMZ6_HUMAN (98-957): 2.96e-119: 386: 100.00		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496927 KIF1A_HUMAN (5-677): 2.15e-108: 371: 24.22		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		653940 KIF11_HUMAN (8-866): 2.09e-162: 505: 27.69		MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56
+	Hs
		216897 KIF1C_HUMAN (5-707): 2.58e-95: 327: 23.49		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		91550 KIF11_HUMAN (8-866): 2.09e-162: 505: 27.69		E7EVA0_HUMAN (217-742): 5.43e-26: 117: 24.87
+	Hs
		166357 KIF3B_HUMAN (8-334): 3.14e-61: 224: 45.88		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Ce
		109403 UN104_CAEEL (7-651): 4.67e-105: 360: 26.29		H2KY94_CAEEL (465-688): 3.39e-25: 107: 33.48
+	Hs
		253242 KI21B_HUMAN (585-957): 5.52e-10: 65.6: 9.78		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497243 KI21A_HUMAN (254-872): 8.4e-10: 65.2: 10.47		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497871 KIF3A_HUMAN (598-830): 6.23e-10: 65.2: 10.73		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496422 KINH_HUMAN (688-957): 5.26e-09: 62.5: 10.04		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00