HitPredict

Interactor 1: AQR (O60306)
RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160)
Gene: AQR

Interactor 2: PRP19 (Q9UMS4)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)
Gene: PRPF19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	28514442, 29395067, 33961781, 35271311
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane GO:0071007 - U2-type catalytic step 2 spliceosome and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1485 Hs			1 504
+	Hs
		230786 AQR_HUMAN (1-1485): 0: 1837: 100.00		SNR40_HUMAN (298-504): 7e-58: 197: 21.91
+	Dm
		1180735 Q9VGG9_DROME (14-1483): 0: 1562: 61.82		Q7KLW9_DROME (26-336): 2.38e-31: 128: 13.52
+	Sp
		144098 CWF11_SCHPO (19-1376): 0: 1071: 22.84		PRP19_SCHPO (3-501): 3.8e-95: 298: 27.24
+	Hs
		1188042 SETX_HUMAN (563-1469): 1.88e-133: 460: 13.54		SNR40_HUMAN (298-504): 7e-58: 197: 21.91
+	Hs
		1272286 RENT1_HUMAN (551-940): 2.94e-69: 257: 16.31		FBXW7_HUMAN (88-458): 1.1e-73: 248: 18.06
+	Hs
		903572 ZNFX1_HUMAN (1002-1326): 3.04e-82: 301: 29.70		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		903413 RENT1_HUMAN (551-940): 2.94e-69: 257: 16.31		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		758134 SMBP2_HUMAN (747-975): 1.78e-29: 129: 18.46		NLE1_HUMAN (93-333): 6.85e-38: 146: 14.86