HitPredict

Interactor 1: KDM1A (O60341)
Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A)
Gene: KDM1A

Interactor 2: SAMD1 (Q6SPF0)
Sterile alpha motif domain-containing protein 1 (SAM domain-containing protein 1) (Atherin)
Gene: SAMD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	24981860, 34709266
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0090308 - regulation of DNA methylation-dependent heterochromatin formation
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 852 Hs			1 538
+	Mm
		88331 KDM1A_MOUSE (1-852): 0: 922: 97.30		SAMD1_MOUSE (1-538): 3.86e-35: 140: 74.16
+	Hs
		231904 KDM1A_HUMAN (1-852): 0: 936: 100.00		ANR17_HUMAN (66-432): 9.29e-27: 117: 15.05
+	Mm
		444972 KDM1A_MOUSE (1-852): 0: 922: 97.30		RPB1_MOUSE (133-246): 9.46e-15: 80: 14.91
+	Hs
		203190 KDM1A_HUMAN (1-852): 0: 936: 100.00		SYNJ1_HUMAN (167-485): 3.5e-10: 65.2: 14.58
+	Mm
		1169754 KDM1A_MOUSE (1-852): 0: 922: 97.30		CHAP1_MOUSE (2-517): 4.17e-10: 64.4: 11.73
+	Mm
		1169769 KDM1A_MOUSE (1-852): 0: 922: 97.30		CIC_MOUSE (17-511): 4.87e-09: 61.4: 13.11
+	Hs
		1239571 KDM1B_HUMAN (160-501): 1.3e-62: 228: 24.86		KMT2C_HUMAN (4-472): 2.2e-22: 104: 12.45