HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: TNKS2 (Q9H2K2)
Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein)
Gene: TNKS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1756 Hs			1 1166
+	Hs
		1061241 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		TNKS2_HUMAN (28-1166): 0: 891: 98.60
+	Hs
		234170 PEPL_HUMAN (1-1756): 3.44e-127: 441: 100.00		TNKS1_HUMAN (2-335): 1.11e-73: 270: 35.95
+	Hs
		1034637 GOGA4_HUMAN (2-1336): 6.16e-43: 175: 9.40		ANFY1_HUMAN (303-1098): 3.92e-70: 258: 14.98
+	Hs
		506803 SPTB1_HUMAN (189-1505): 5e-14: 80.3: 10.93		ANK1_HUMAN (1-395): 7.32e-83: 300: 24.09
+	Hs
		310054 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		TNKS1_HUMAN (2-335): 1.11e-73: 270: 35.95
+	Mm
		57440 PLEC_MOUSE (2-1071): 1.05e-33: 145: 10.58		A2AM57_MOUSE (489-913): 5.73e-50: 195: 22.49
+	Mm
		57416 Q6S385_MOUSE (2-1071): 1.16e-33: 144: 10.58		A2AM57_MOUSE (489-913): 5.73e-50: 195: 22.49
+	Mm
		57429 MYH9_MOUSE (13-946): 1.66e-20: 101: 9.74		A2AM57_MOUSE (489-913): 5.73e-50: 195: 22.49
+	Mm
		57397 Q3UFT0_MOUSE (498-1306): 5.16e-16: 86.2: 14.06		A2AM57_MOUSE (489-913): 5.73e-50: 195: 22.49
+	Hs
		1021404 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		ANK3_HUMAN (836-1140): 9.74e-22: 104: 9.18
+	Mm
		57340 DESP_MOUSE (1619-1753): 8.47e-14: 79.5: 31.62		A2AM57_MOUSE (489-913): 5.73e-50: 195: 22.49
+	Rn
		251022 PLEC_RAT (2-1172): 1.05e-34: 148: 9.70		ANK3_RAT (836-1140): 2.14e-20: 100: 9.88
+	Hs
		724782 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		ANK2_HUMAN (799-1145): 3.5e-21: 102: 8.73
+	Mm
		561172 SPTN1_MOUSE (4-1212): 2.57e-19: 97.6: 10.27		ANK2_MOUSE (799-1156): 6.19e-22: 105: 9.00
+	Hs
		1021399 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		ANK3_HUMAN (836-1140): 9.74e-22: 104: 9.18
+	Hs
		965102 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		ANK2_HUMAN (799-1145): 3.5e-21: 102: 8.73
+	Mm
		82740 B9EKJ1_MOUSE (4-1212): 8.41e-19: 96.1: 10.31		ANK3_MOUSE (836-1140): 1.36e-20: 100: 9.49
+	Mm
		103598 Q3UGX2_MOUSE (91-1661): 3.92e-18: 93.8: 11.40		ANK3_MOUSE (836-1140): 1.36e-20: 100: 9.49
+	Hs
		164611 SPTN2_HUMAN (73-1521): 7.79e-13: 76.4: 12.03		ANK3_HUMAN (836-1140): 9.74e-22: 104: 9.18
+	Hs
		164604 SPTN2_HUMAN (73-1521): 7.79e-13: 76.4: 12.03		ANK2_HUMAN (799-1145): 3.5e-21: 102: 8.73