HitPredict

Interactor 1: DOK2 (O60496)
Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2))
Gene: DOK2

Interactor 2: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	15831486
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 450
+	Mm
		250951 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		CSK_MOUSE (1-450): 0: 543: 99.11
+	Hs
		235031 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83
+	Hs
		235036 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		FYN_HUMAN (12-442): 1.26e-170: 491: 36.77
+	Hs
		235040 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		SRC_HUMAN (12-442): 8.48e-171: 491: 39.33
+	Hs
		235037 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		YES_HUMAN (12-442): 5.99e-170: 490: 37.30
+	Hs
		235035 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		LCK_HUMAN (5-443): 1.95e-168: 485: 38.55
+	Hs
		235052 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		TXK_HUMAN (10-443): 4.44e-159: 461: 36.75
+	Mm
		250948 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		ABL1_MOUSE (5-447): 5.69e-165: 495: 37.83
+	Mm
		250949 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		SRC_MOUSE (12-442): 1.93e-169: 488: 39.55
+	Mm
		782845 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		CSK_MOUSE (1-450): 0: 543: 99.11
+	Mm
		250950 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		LYN_MOUSE (4-445): 3.96e-160: 463: 36.90
+	Mm
		337623 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		ABL1_MOUSE (5-447): 5.69e-165: 495: 37.83
+	Hs
		337542 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83
+	Hs
		523124 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		SRC_HUMAN (12-442): 8.48e-171: 491: 39.33
+	Hs
		433460 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		YES_HUMAN (12-442): 5.99e-170: 490: 37.30
+	Hs
		442876 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		HCK_HUMAN (3-445): 6.38e-167: 481: 36.32
+	Hs
		454844 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		FGR_HUMAN (12-442): 4.47e-165: 476: 38.43
+	Mm
		639441 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		LYN_MOUSE (4-445): 3.96e-160: 463: 36.90
+	Hs
		433966 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		LYN_HUMAN (4-445): 3.75e-160: 463: 37.12
+	Hs
		789005 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		TEC_HUMAN (8-450): 6.4e-150: 442: 36.96