HitPredict

Interactor 1: VINEX (O60504)
Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3)
Gene: SORBS3

Interactor 2: DLG5 (Q8TDM6)
Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)
Gene: DLG5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.836

Property	Details
Experiments	12657639, 33961781
Identification Methods	two hybrid, pull down, affinity chromatography technology, anti tag coimmunoprecipitation, experimental interaction detection
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Guanylate_kin~SH3_1
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 671 Hs			1 1919
+	Hs
		1052264 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		DLG5_HUMAN (1-1919): 0: 936: 100.00
+	Mm
		1113245 SRBS2_MOUSE (56-671): 5.81e-63: 229: 27.24		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Mm
		1143326 SRBS1_MOUSE (88-671): 6.32e-41: 162: 25.89		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Mm
		561163 SPTN1_MOUSE (180-622): 2.42e-38: 155: 15.27		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Mm
		1143413 SH3R3_MOUSE (237-603): 4.08e-16: 84.6: 12.03		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Mm
		1143451 SH3K1_MOUSE (614-671): 2.08e-13: 75.5: 25.86		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Mm
		1141133 GRB2_MOUSE (615-669): 2.48e-14: 74.6: 28.57		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Hs
		1232491 SH3K1_HUMAN (614-671): 3.44e-13: 74.9: 25.86		PALS1_HUMAN (1501-1916): 9.35e-98: 333: 19.50
+	Hs
		1314994 SRBS1_HUMAN (522-671): 2.49e-20: 98.4: 35.53		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Mm
		761854 SRC8_MOUSE (431-669): 1.14e-20: 98.1: 17.57		ZO1_MOUSE (1227-1439): 1.66e-09: 65.3: 26.34
+	Hs
		990840 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81
+	Hs
		1285211 SH3K1_HUMAN (614-671): 3.44e-13: 74.9: 25.86		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		1126376 SH319_HUMAN (39-671): 7.07e-13: 73.9: 10.88		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		1354510 CD2AP_HUMAN (614-671): 8.75e-11: 67.2: 27.12		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		990838 SPTN1_HUMAN (511-671): 1.08e-12: 73.9: 9.94		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81
+	Hs
		990858 SH319_HUMAN (39-671): 7.07e-13: 73.9: 10.88		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81