HitPredict

Interactor 1: BUB1B (O60566)
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1)
Gene: BUB1B

Interactor 2: CDC20 (Q12834)
Cell division cycle protein 20 homolog (p55CDC)
Gene: CDC20

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.998

The method score is based on:

Property Details
Experiments 24464857, 25833949, 25669885, 25750436, 25482201, 25306918, 26811472, 27114510, 28514442, 23007648, 26912231, 26960431, 27939943, 28404789, 11907259, 11030144, 12196507, 29432156, 33961781, 18997788 and 47 others

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Identification Methods affinity chromatography technology, pull down, enzymatic study, x-ray crystallography, unspecified method, two hybrid, biochemical, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, protein kinase assay and 2 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains ANAPC4_WD40~Mad3_BUB1_I, Mad3_BUB1_I~WD40
Common GO terms GO:0000776 - kinetochore
GO:0005680 - anaphase-promoting complex
GO:0005813 - centrosome
GO:0005819 - spindle
GO:0005829 - cytosol
and 3 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1050
Hs

1 499
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024