HitPredict

Interactor 1: BUB1B (O60566)
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1)
Gene: BUB1B

Interactor 2: 2A5A (Q15172)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha)
Gene: PPP2R5A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.679

Property	Details
Experiments	23345399, 26811472, 37219487
Identification Methods	two hybrid, biochemical, unspecified method, pull down, affinity chromatography technology, phage display
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1050 Hs			1 486
+	Hs
		236929 BUB1B_HUMAN (1-1050): 0: 826: 100.00		2A5D_HUMAN (12-477): 0: 712: 64.47
+	Hs
		236938 BUB1B_HUMAN (1-1050): 0: 826: 100.00		2A5E_HUMAN (9-470): 0: 707: 78.36
+	Hs
		236934 BUB1B_HUMAN (1-1050): 0: 826: 100.00		2A5B_HUMAN (2-465): 0: 705: 71.77
+	Hs
		236922 BUB1B_HUMAN (1-1050): 0: 826: 100.00		2A5G_HUMAN (46-484): 0: 701: 68.32
+	Dm
		1213388 AKT1_DROME (514-1044): 3.97e-116: 373: 11.81		Q9VB23_DROME (47-466): 0: 702: 77.91
+	Ce
		185206 AKT1_CAEEL (632-1044): 1.61e-107: 347: 13.36		2A51_CAEEL (11-468): 0: 702: 67.25