Protein: CSN1
COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH)

Gene: CSN1, GPS1
Organism: Homo sapiens
Interactions: 194
UniProt ID: Q13098

Gene Ontology (top 5):
GO:0000338 - protein deneddylation
GO:0005095 - GTPase inhibitor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1094443

CSN3
COP9 signalosome complex subunit 3

17

20

Small-scale

0.985

High

958628

CSN2
COP9 signalosome complex subunit 2

17

17

Small-scale

0.985

High

1094404

CSN8
COP9 signalosome complex subunit 8

12

7

Small-scale

0.978

High

1094361

CSN6
COP9 signalosome complex subunit 6

10

20

Small-scale

0.977

High

1094405

CSN4
COP9 signalosome complex subunit 4

7

20

Small-scale

0.956

High

1094420

CSN7B
COP9 signalosome complex subunit 7b

6

20

Small-scale

0.943

High

1094437

CSN7A
COP9 signalosome complex subunit 7a

5

20

Small-scale

0.919

High

1094354

KLH10
Kelch-like protein 10

3

15

High-throughput

0.855

High

1094434

KLH13
Kelch-like protein 13

2

17

High-throughput

0.776

High

1094339

ELOB
Elongin-B

2

1

Small-scale

0.768

High

1094391

CSN5
COP9 signalosome complex subunit 5

15

20

Small-scale

0.762

High

241552

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.754

High

1094332

CUL3
Cullin-3

10

20

Small-scale

0.752

High

1094333

CUL4A
Cullin-4A

9

20

Small-scale

0.750

High

1094334

CUL4B
Cullin-4B

8

20

Small-scale

0.746

High

1094330

CUL1
Cullin-1

7

20

Small-scale

0.742

High

1094344

DDB1
DNA damage-binding protein 1

6

4

Small-scale

0.732

High

1094387

DDB2
DNA damage-binding protein 2

5

10

Small-scale

0.706

High

1094370

KLH36
Kelch-like protein 36

2

17

High-throughput

0.694

High

320821

KLH18
Kelch-like protein 18

1

15

High-throughput

0.691

High

1094342

NEDD8
Ubiquitin-like protein NEDD8

1

4

High-throughput

0.691

High

1094355

KLH24
Kelch-like protein 24

1

15

High-throughput

0.691

High

1094431

KLHL8
Kelch-like protein 8

1

15

High-throughput

0.691

High

1094432

KLHL9
Kelch-like protein 9

1

17

High-throughput

0.691

High

1094331

CUL2
Cullin-2

4

20

Small-scale

0.691

High

1094386

CSN9
COP9 signalosome complex subunit 9

4

1

Small-scale

0.686

High

1094322

ERCC8
DNA excision repair protein ERCC-8

4

8

Small-scale

0.683

High

848130

MAGA1
Melanoma-associated antigen 1

3

3

High-throughput

0.667

High

957346

UBC12
NEDD8-conjugating enzyme Ubc12

3

4

High-throughput

0.667

High

1094341

STK11
Serine/threonine-protein kinase STK11

3

4

High-throughput

0.662

High

1094382

DCA11
DDB1- and CUL4-associated factor 11

3

4

High-throughput

0.662

High

1094384

DCAF4
DDB1- and CUL4-associated factor 4

3

3

High-throughput

0.662

High

1094416

BTBD1
BTB/POZ domain-containing protein 1

3

19

High-throughput

0.662

High

1094448

FBX7
F-box only protein 7

3

1

High-throughput

0.662

High

1094428

DTL
Denticleless protein homolog

3

9

Small-scale

0.650

High

1094449

DCAF1
DDB1- and CUL4-associated factor 1

3

6

Small-scale

0.650

High

1094321

CSN1
COP9 signalosome complex subunit 1

1

18

Small-scale

0.647

High

1094412

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

3

6

Small-scale

0.633

High

342402

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

2

2

High-throughput

0.628

High

1094362

DET1
DET1 homolog

2

1

High-throughput

0.628

High

1094368

FXL14
F-box/LRR-repeat protein 14

2

1

High-throughput

0.628

High

1094325

SKP2
S-phase kinase-associated protein 2

2

5

Small-scale

0.611

High

1094328

IRF5
Interferon regulatory factor 5

2

3

Small-scale

0.611

High

1094392

CUL5
Cullin-5

2

20

High-throughput

0.611

High

1094347

DCAF6
DDB1- and CUL4-associated factor 6

2

12

High-throughput

0.601

High

1094372

WDTC1
WD and tetratricopeptide repeats protein 1

2

11

High-throughput

0.601

High

1094389

APBP2
Amyloid protein-binding protein 2

2

5

High-throughput

0.601

High

1094395

FBX17
F-box only protein 17

2

4

High-throughput

0.601

High

1094398

LLR1
Leucine-rich repeat protein 1

2

2

High-throughput

0.601

High

1094407

BTBD2
BTB/POZ domain-containing protein 2

2

19

High-throughput

0.601

High

1094425

ASB6
Ankyrin repeat and SOCS box protein 6

2

3

High-throughput

0.601

High

1094433

KLH42
Kelch-like protein 42

2

18

High-throughput

0.601

High

1094441

FEM1B
Protein fem-1 homolog B

2

3

High-throughput

0.601

High

318751

RHBT1
Rho-related BTB domain-containing protein 1

3

8

High-throughput

0.593

High

1094411

RHBT2
Rho-related BTB domain-containing protein 2

3

8

High-throughput

0.593

High

683448

IKBA
NF-kappa-B inhibitor alpha

2

3

Small-scale

0.584

High

830656

CCNF
Cyclin-F

2

9

High-throughput

0.584

High

983778

RBX1
E3 ubiquitin-protein ligase RBX1

2

4

Small-scale

0.584

High

1094366

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

2

4

Small-scale

0.584

High

1094429

CNOT2
CCR4-NOT transcription complex subunit 2

2

0

High-throughput

0.580

High

1094383

TP4AP
Short transient receptor potential channel 4-associated protein

2

0

High-throughput

0.576

High

1094413

ZY11B
Protein zyg-11 homolog B

2

0

High-throughput

0.576

High

1094426

DCA16
DDB1- and CUL4-associated factor 16

2

0

High-throughput

0.576

High

1094345

KLH12
Kelch-like protein 12

1

15

High-throughput

0.575

High

1094417

SP130
Histone deacetylase complex subunit SAP130

1

2

Small-scale

0.561

High

1094408

CAR11
Caspase recruitment domain-containing protein 11

1

1

Small-scale

0.554

High

1094438

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

2

Small-scale

0.554

High

1015403

RHOG
Rho-related GTP-binding protein RhoG

2

1

Small-scale

0.552

High

50365

PXDNL
Probable oxidoreductase PXDNL

2

1

High-throughput

0.549

High

1094409

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

2

High-throughput

0.541

High

354686

PAK4
Serine/threonine-protein kinase PAK 4

1

2

High-throughput

0.536

High

857437

NOTC1
Neurogenic locus notch homolog protein 1

1

1

High-throughput

0.536

High

1037787

IRF8
Interferon regulatory factor 8

1

3

High-throughput

0.536

High

1094375

KCTD6
BTB/POZ domain-containing protein KCTD6

1

6

High-throughput

0.536

High

1094396

DCNL1
DCN1-like protein 1

1

1

High-throughput

0.536

High

1094397

FEM1C
Protein fem-1 homolog C

1

3

High-throughput

0.536

High

1094442

FBX10
F-box only protein 10

1

1

High-throughput

0.536

High

1094452

ASB3
Ankyrin repeat and SOCS box protein 3

1

1

High-throughput

0.536

High

1094456

USH1C
Harmonin

1

2

High-throughput

0.536

High

938649

ALR
FAD-linked sulfhydryl oxidase ALR

1

1

Small-scale

0.534

High

105849

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

1094436

WRP73
WD repeat-containing protein WRAP73

1

3

High-throughput

0.515

High

1094446

BCS1
Mitochondrial chaperone BCS1

1

20

High-throughput

0.514

High

212950

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.513

High

894537

GDIB
Rab GDP dissociation inhibitor beta

1

0

High-throughput

0.513

High

1094424

AP5S1
AP-5 complex subunit sigma-1

1

0

High-throughput

0.513

High

1094445

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

0

Small-scale

0.506

High

185650

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.501

High

1094388

IP6K1
Inositol hexakisphosphate kinase 1

1

1

Small-scale

0.501

High

1094399

SENP8
Sentrin-specific protease 8

1

1

Small-scale

0.501

High

862827

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.493

High

1094346

ANR39
Ankyrin repeat domain-containing protein 39

1

4

High-throughput

0.489

High

1094393

TRI63
E3 ubiquitin-protein ligase TRIM63

1

13

High-throughput

0.481

High

1094410

TRI55
Tripartite motif-containing protein 55

1

16

High-throughput

0.481

High

822637

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.480

High

1094336

SCRIB
Protein scribble homolog

1

0

High-throughput

0.480

High

1094394

FBXW5
F-box/WD repeat-containing protein 5

1

0

Small-scale

0.479

High

227533

SPOP
Speckle-type POZ protein

1

5

High-throughput

0.479

High

279353

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

315533

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

445852

ENOA
Alpha-enolase

1

1

High-throughput

0.479

High

537077

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

588583

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

695339

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

731247

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

767187

MERL
Merlin

1

1

Small-scale

0.479

High

768077

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

872277

SOX2
Transcription factor SOX-2

1

2

Small-scale

0.479

High

945572

FBXW4
F-box/WD repeat-containing protein 4

1

6

Small-scale

0.479

High

954800

PSA6
Proteasome subunit alpha type-6

1

20

Small-scale

0.479

High

970424

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

1045236

TF65
Transcription factor p65

1

1

Small-scale

0.479

High

1067252

EP300
Histone acetyltransferase p300

1

8

High-throughput

0.479

High

1083346

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

4

Small-scale

0.479

High

1094323

TIF1B
Transcription intermediary factor 1-beta

1

6

High-throughput

0.479

High

1094337

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

High-throughput

0.479

High

1094340

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

6

High-throughput

0.479

High

1094353

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

1094357

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

1

High-throughput

0.479

High

1094359

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

1094363

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1094365

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

8

High-throughput

0.479

High

1094374

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1094376

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1094380

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.479

High

1094385

PHIP
PH-interacting protein

1

5

Small-scale

0.479

High

1094390

REQU
Zinc finger protein ubi-d4

1

1

High-throughput

0.479

High

1094403

CRBN
Protein cereblon

1

1

Small-scale

0.479

High

1094414

KLHL4
Kelch-like protein 4

1

16

High-throughput

0.479

High

1094418

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

1094422

FBX6
F-box only protein 6

1

4

High-throughput

0.479

High

1094427

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1094439

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1094450

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

6

Small-scale

0.479

High

1094451

ASB4
Ankyrin repeat and SOCS box protein 4

1

1

Small-scale

0.479

High

1094455

MAFB
Transcription factor MafB

1

8

High-throughput

0.479

High

218133

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

341935

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

615215

IL1RA
Interleukin-1 receptor antagonist protein

1

0

Small-scale

0.458

High

667286

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

992157

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

1094329

ITPK1
Inositol-tetrakisphosphate 1-kinase

1

0

Small-scale

0.458

High

1094369

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

1094377

SYNE1
Nesprin-1

1

0

High-throughput

0.458

High

1094419

EXO5
Exonuclease V

1

0

Small-scale

0.458

High

1094401

CEP63
Centrosomal protein of 63 kDa

1

2

High-throughput

0.457

High

363210

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.445

High

429809

JUN
Transcription factor Jun

1

7

High-throughput

0.445

High

529725

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

611102

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

7

High-throughput

0.445

High

848373

MAGA6
Melanoma-associated antigen 6

1

3

High-throughput

0.445

High

854837

RECQ1
ATP-dependent DNA helicase Q1

1

6

High-throughput

0.445

High

878444

PAXI
Paxillin

1

1

High-throughput

0.445

High

959322

RAP1B
Ras-related protein Rap-1b

1

1

High-throughput

0.445

High

1094335

FHL1
Four and a half LIM domains protein 1

1

2

High-throughput

0.445

High

1094338

LRC14
Leucine-rich repeat-containing protein 14

1

2

High-throughput

0.445

High

1094343

CSRP2
Cysteine and glycine-rich protein 2

1

1

High-throughput

0.445

High

1094348

DCA10
DDB1- and CUL4-associated factor 10

1

3

High-throughput

0.445

High

1094349

DCAF8
DDB1- and CUL4-associated factor 8

1

13

High-throughput

0.445

High

1094352

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.445

High

1094367

SMAP1
Stromal membrane-associated protein 1

1

1

High-throughput

0.445

High

1094406

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.445

High

1094415

KLC2
Kinesin light chain 2

1

5

High-throughput

0.445

High

1094430

LMCD1
LIM and cysteine-rich domains protein 1

1

2

High-throughput

0.445

High

1094435

ANFY1
Rabankyrin-5

1

2

High-throughput

0.445

High

1094444

TRI33
E3 ubiquitin-protein ligase TRIM33

1

6

High-throughput

0.445

High

1094447

NISCH
Nischarin

1

1

High-throughput

0.445

High

1094453

ASB1
Ankyrin repeat and SOCS box protein 1

1

8

High-throughput

0.445

High

1094421

TBC17
TBC1 domain family member 17

1

0

High-throughput

0.438

High

411843

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

1094356

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1094371

FBXL6
F-box/LRR-repeat protein 6

1

5

High-throughput

0.437

High

1094373

DC4L2
DDB1- and CUL4-associated factor 4-like protein 2

1

3

Small-scale

0.437

High

1094378

O10G8
Olfactory receptor 10G8

1

1

High-throughput

0.437

High

1094379

O10G7
Olfactory receptor 10G7

1

1

High-throughput

0.437

High

861483

GNPI1
Glucosamine-6-phosphate deaminase 1

1

0

High-throughput

0.426

High

1094324

STX3
Syntaxin-3

1

0

High-throughput

0.426

High

1094327

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.426

High

1094364

I2BP2
Interferon regulatory factor 2-binding protein 2

1

0

High-throughput

0.426

High

62501

S35F4
Solute carrier family 35 member F4

1

2

High-throughput

0.407

High

906269

GPC3
Glypican-3

1

1

High-throughput

0.407

High

1094350

DC121
DDB1- and CUL4-associated factor 12-like protein 1

1

1

High-throughput

0.407

High

1094360

KCTD9
BTB/POZ domain-containing protein KCTD9

1

7

High-throughput

0.407

High

1094381

SHKB1
SH3KBP1-binding protein 1

1

8

High-throughput

0.407

High

1094454

KCTD3
BTB/POZ domain-containing protein KCTD3

1

7

High-throughput

0.407

High

1094351

LPCT4
Lysophospholipid acyltransferase LPCAT4

1

0

High-throughput

0.249

Low

437671

HEPS
Serine protease hepsin

1

0

High-throughput

0.232

Low

1094326

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1094358

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low

1094400

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low

1094402

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.232

Low

1094423

CYRIB
CYFIP-related Rac1 interactor B

1

0

High-throughput

0.232

Low

1094440

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025