HitPredict

Interactor 1: DIAP1 (O60610)
Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1)
Gene: DIAPH1

Interactor 2: RHOC (P08134)
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Gene: RHOC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.899

Property	Details
Experiments	28514442, 33961781, 31871319, 18218625
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	Drf_FH3~Ras, Drf_GBD~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1272 Hs			1 193
+	Hs
		237579 DIAP1_HUMAN (1-1272): 0: 953: 100.00		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		237586 DIAP1_HUMAN (1-1272): 0: 953: 100.00		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		237588 DIAP1_HUMAN (1-1272): 0: 953: 100.00		RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92
+	Hs
		237577 DIAP1_HUMAN (1-1272): 0: 953: 100.00		CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30
+	Hs
		237584 DIAP1_HUMAN (1-1272): 0: 953: 100.00		RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82
+	Hs
		237576 DIAP1_HUMAN (1-1272): 0: 953: 100.00		RAC3_HUMAN (1-179): 9.72e-75: 224: 57.54
+	Hs
		243097 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		243100 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		243101 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92
+	Hs
		243096 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30
+	Hs
		243089 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RAC2_HUMAN (1-193): 2.27e-77: 231: 54.12
+	Hs
		243099 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82
+	Hs
		900958 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		925658 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		436532 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00
+	Hs
		243095 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RAC3_HUMAN (1-179): 9.72e-75: 224: 57.54
+	Hs
		894489 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30
+	Hs
		545645 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RAC2_HUMAN (1-193): 2.27e-77: 231: 54.12
+	Hs
		916010 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82
+	Hs
		892621 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RAC3_HUMAN (1-179): 9.72e-75: 224: 57.54