Protein: RRS1
Regulator of ribosome biosynthesis

Gene: RRS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 171
UniProt ID: Q08746

Gene Ontology (top 5):
GO:0000055 - ribosomal large subunit export from nucleus
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0030687 - preribosome, large subunit precursor

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

782477

RPF2
Ribosome biogenesis protein RPF2

11

3

Small-scale

0.980

High

804681

SSF1
Ribosome biogenesis protein SSF1

2

1

High-throughput

0.776

High

1062786

BRX1
Ribosome biogenesis protein BRX1

2

10

Small-scale

0.757

High

780339

EBP2
rRNA-processing protein EBP2

9

2

Small-scale

0.749

High

923220

NOG2
Nucleolar GTP-binding protein 2

7

4

Small-scale

0.737

High

805108

RPF1
Ribosome production factor 1

2

1

High-throughput

0.737

High

919031

PESC
Pescadillo homolog

4

1

High-throughput

0.683

High

814410

NOC2
Nucleolar complex protein 2

5

0

Small-scale

0.678

High

1039650

NOG1
Nucleolar GTP-binding protein 1

4

2

Small-scale

0.672

High

830204

NOP2
25S rRNA

3

3

Small-scale

0.650

High

924863

NOP15
Ribosome biogenesis protein 15

3

3

High-throughput

0.650

High

1064861

MAK21
Ribosome biogenesis protein MAK21

3

5

High-throughput

0.646

High

803961

CIC1
Proteasome-interacting protein CIC1

3

2

High-throughput

0.643

High

1060745

NOC3
Nucleolar complex-associated protein 3

3

4

High-throughput

0.643

High

827630

RLP7
Ribosome biogenesis protein RLP7

3

3

Small-scale

0.642

High

682412

SPB4
ATP-dependent rRNA helicase SPB4

3

5

High-throughput

0.633

High

1043307

HAS1
ATP-dependent RNA helicase HAS1

3

6

High-throughput

0.633

High

503447

RL11A
Large ribosomal subunit protein uL5A

3

2

Small-scale

0.630

High

1064865

RL11B
Large ribosomal subunit protein uL5B

3

2

Small-scale

0.614

High

924345

NOP13
Nucleolar protein 13

2

1

High-throughput

0.601

High

1046074

DHR1
Probable ATP-dependent RNA helicase DHR1

2

3

High-throughput

0.601

High

1050197

RRP5
rRNA biogenesis protein RRP5

2

2

High-throughput

0.601

High

923032

DBP6
ATP-dependent RNA helicase DBP6

2

4

High-throughput

0.594

High

918049

CGR1
rRNA-processing protein CGR1

2

0

High-throughput

0.588

High

673597

NLE1
Ribosome assembly protein 4

2

1

Small-scale

0.584

High

1064858

NOP53
Ribosome biogenesis protein NOP53

2

2

High-throughput

0.584

High

1064863

DBP10
ATP-dependent RNA helicase DBP10

2

2

High-throughput

0.584

High

844652

UTP10
U3 small nucleolar RNA-associated protein 10

2

0

High-throughput

0.576

High

750165

MRT4
Ribosome assembly factor MRT4

2

2

High-throughput

0.571

High

807169

FKBP3
Peptidyl-prolyl cis-trans isomerase

2

1

High-throughput

0.571

High

1064854

NIP7
60S ribosome subunit biogenesis protein NIP7

2

2

High-throughput

0.571

High

1064856

YTM1
Ribosome biogenesis protein YTM1

2

3

High-throughput

0.571

High

864848

MPS3
Spindle pole body assembly component MPS3

1

0

Small-scale

0.568

High

816809

NOP16
Nucleolar protein 16

2

0

High-throughput

0.547

High

1044233

ARX1
Probable metalloprotease ARX1

2

0

High-throughput

0.547

High

743307

PP12
Serine/threonine-protein phosphatase PP1-2

1

1

High-throughput

0.536

High

1064808

RS10A
Small ribosomal subunit protein eS10A

2

1

High-throughput

0.533

High

427470

RLA0
Large ribosomal subunit protein uL10

2

2

Small-scale

0.521

High

570172

RL3
Large ribosomal subunit protein uL3

2

1

Small-scale

0.521

High

632757

DBP4
ATP-dependent RNA helicase HCA4

1

6

High-throughput

0.515

High

781664

DBP7
ATP-dependent RNA helicase DBP7

1

5

High-throughput

0.515

High

816186

DPO5
rDNA transcriptional regulator POL5

1

1

High-throughput

0.515

High

864541

MTR4
ATP-dependent RNA helicase DOB1

1

2

High-throughput

0.515

High

623030

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

745671

ORC2
Origin recognition complex subunit 2

1

0

High-throughput

0.493

High

805529

ORC6
Origin recognition complex subunit 6

1

0

High-throughput

0.493

High

918847

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.493

High

1054904

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.493

High

820012

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.489

High

1064747

HRK1
Serine/threonine-protein kinase HRK1

1

1

High-throughput

0.489

High

1064859

RTK1
Probable serine/threonine-protein kinase RTK1

1

1

High-throughput

0.489

High

149993

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

410377

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

436213

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

442150

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

512696

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

513786

RL2A
Large ribosomal subunit protein uL2A

1

2

High-throughput

0.479

High

514871

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

534159

MAK16
Protein MAK16

1

1

High-throughput

0.479

High

633202

MAK11
Protein MAK11

1

3

High-throughput

0.479

High

677255

SPB1
27S pre-rRNA

1

3

High-throughput

0.479

High

677603

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

708798

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.479

High

745111

AFG2
ATPase family gene 2 protein

1

1

High-throughput

0.479

High

746688

DRS1
ATP-dependent RNA helicase DRS1

1

4

High-throughput

0.479

High

747619

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

763134

RRP1
Ribosomal RNA-processing protein 1

1

2

High-throughput

0.479

High

791127

NOP4
Nucleolar protein 4

1

2

High-throughput

0.479

High

816925

NUG1
Nuclear GTP-binding protein NUG1

1

4

High-throughput

0.479

High

818291

NSA2
Ribosome biogenesis protein NSA2

1

1

High-throughput

0.479

High

917578

NSA1
Ribosome biogenesis protein NSA1

1

1

High-throughput

0.479

High

924258

IPI3
Pre-rRNA-processing protein IPI3

1

2

High-throughput

0.479

High

925453

RCM1
25S rRNA

1

3

High-throughput

0.479

High

1046124

RRB1
Ribosome assembly protein RRB1

1

3

High-throughput

0.479

High

1046532

PUF6
Pumilio homology domain family member 6

1

1

High-throughput

0.479

High

1046818

UTP14
U3 small nucleolar RNA-associated protein 14

1

2

High-throughput

0.479

High

1047298

ERB1
Ribosome biogenesis protein ERB1

1

2

High-throughput

0.479

High

1054263

FKBP4
FK506-binding protein 4

1

1

High-throughput

0.479

High

1054373

JIP5
WD repeat-containing protein JIP5

1

3

High-throughput

0.479

High

1055510

NOC4
Nucleolar complex protein 4

1

5

High-throughput

0.479

High

1060830

RLP24
Ribosome biogenesis protein RLP24

1

1

High-throughput

0.479

High

1062346

NOP12
Nucleolar protein 12

1

4

High-throughput

0.479

High

1064862

RL7B
Large ribosomal subunit protein uL30B

1

3

High-throughput

0.479

High

1064864

IF6
Eukaryotic translation initiation factor 6

1

1

High-throughput

0.479

High

657008

BUR1
Serine/threonine-protein kinase BUR1

1

1

High-throughput

0.470

High

874321

PUS4
tRNA pseudouridine synthase 4

1

2

High-throughput

0.470

High

917703

LSG1
Large subunit GTPase 1

1

4

High-throughput

0.470

High

1038786

SKI8
Antiviral protein SKI8

1

3

High-throughput

0.470

High

1045022

DOT1
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.470

High

1054167

PDP3
NuA3 HAT complex component PDP3

1

2

High-throughput

0.470

High

433887

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

677978

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.458

High

689705

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

735208

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

780719

RRP14
Ribosomal RNA-processing protein 14

1

0

High-throughput

0.458

High

795855

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

798343

ENP1
Essential nuclear protein 1

1

0

High-throughput

0.458

High

805020

IPI1
Pre-rRNA-processing protein IPI1

1

0

High-throughput

0.458

High

806672

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.458

High

825396

BMT5
25S rRNA

1

0

High-throughput

0.458

High

850032

LOC1
60S ribosomal subunit assembly/export protein LOC1

1

0

High-throughput

0.458

High

864198

ALB1
Ribosome biogenesis protein ALB1

1

0

High-throughput

0.458

High

925110

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

1044911

RRP17
Ribosomal RNA-processing protein 17

1

0

High-throughput

0.458

High

1055480

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.458

High

1061408

BUD20
Bud site selection protein 20

1

0

High-throughput

0.458

High

1064855

MDN1
Midasin

1

0

High-throughput

0.458

High

432721

RL7A
Large ribosomal subunit protein uL30A

1

3

High-throughput

0.445

High

1025197

SEN1
Helicase SEN1

1

2

Small-scale

0.445

High

800633

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

1

Small-scale

0.439

High

898165

MRK1
Serine/threonine-protein kinase MRK1

1

1

Small-scale

0.439

High

381300

H2B1
Histone H2B.1

1

1

High-throughput

0.437

High

381662

H2B2
Histone H2B.2

1

1

High-throughput

0.437

High

383931

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

435413

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.437

High

436544

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.437

High

455301

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

504456

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

513266

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

680128

CDC48
Cell division control protein 48

1

1

High-throughput

0.437

High

708419

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

753632

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

785991

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.437

High

792290

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.437

High

802428

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

874573

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

897519

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.437

High

1033612

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

1064860

YRA1
RNA annealing protein YRA1

1

1

Small-scale

0.437

High

434455

RL15A
Large ribosomal subunit protein eL15A

1

1

High-throughput

0.407

High

511348

RL43A
Large ribosomal subunit protein eL43A

1

1

High-throughput

0.407

High

546587

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.407

High

569876

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.407

High

601146

RL8A
Large ribosomal subunit protein eL8A

1

1

High-throughput

0.407

High

885107

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.407

High

963769

H3
Histone H3

1

2

High-throughput

0.407

High

684871

RL5
Large ribosomal subunit protein uL18

4

0

Small-scale

0.364

High

923143

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.279

Low

1030263

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

0

High-throughput

0.279

Low

1033868

KIN4
Serine/threonine-protein kinase KIN4

1

0

High-throughput

0.279

Low

1053632

RGC1
Regulator of the glycerol channel 1

1

0

High-throughput

0.279

Low

585740

UBC4
Ubiquitin-conjugating enzyme E2 4

1

0

High-throughput

0.269

Low

781124

YKC3
Uncharacterized protein YKL023W

1

0

High-throughput

0.269

Low

797666

GDT1
Divalent cation/proton antiporter GDT1

1

0

High-throughput

0.269

Low

802810

OSH3
Oxysterol-binding protein homolog 3

1

0

High-throughput

0.269

Low

805762

YHS7
Uncharacterized protein YHR127W

1

0

High-throughput

0.269

Low

814151

SAW1
Single-strand annealing weakened protein 1

1

0

High-throughput

0.269

Low

816978

BIM1
Protein BIM1

1

0

High-throughput

0.269

Low

850237

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.269

Low

898938

OCA1
Putative tyrosine-protein phosphatase OCA1

1

0

High-throughput

0.269

Low

1044976

RPN9
26S proteasome regulatory subunit RPN9

1

0

High-throughput

0.269

Low

1051549

NSE3
Non-structural maintenance of chromosome element 3

1

0

High-throughput

0.269

Low

1053507

YL407
Uncharacterized protein YLR407W

1

0

High-throughput

0.269

Low

1064853

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

High-throughput

0.269

Low

1064857

THP3
Protein THP3

1

0

High-throughput

0.269

Low

1064867

SAS5
Something about silencing protein 5

1

0

High-throughput

0.269

Low

550703

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.265

Low

503285

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

645006

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

High-throughput

0.249

Low

745902

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.249

Low

778573

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

812729

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

826101

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.249

Low

925394

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

1046322

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

1059385

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

1064273

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

1064866

DPH3
Diphthamide biosynthesis protein 3

1

0

Small-scale

0.249

Low

915001

NUP84
Nucleoporin NUP84

1

0

High-throughput

0.238

Low

383371

RL28
Large ribosomal subunit protein uL15

1

0

High-throughput

0.232

Low

394975

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025