HitPredict

Interactor 1: LMX1B (O60663)
LIM homeobox transcription factor 1-beta (LIM/homeobox protein 1.2) (LMX-1.2) (LIM/homeobox protein LMX1B)
Gene: LMX1B

Interactor 2: LDB1 (Q86U70)
LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)
Gene: LDB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	25416956, 26186194, 28514442, 32296183, 33961781, unassigned1304, 20211142, 12792813
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0030182 - neuron differentiation GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 402 Hs			1 411
+	Mm
		291994 LMX1B_MOUSE (1-402): 2.75e-99: 302: 98.01		LDB1_MOUSE (1-411): 0: 760: 99.76
+	Mm
		936889 LMX1A_MOUSE (24-402): 4.97e-85: 265: 62.60		LDB1_MOUSE (1-411): 0: 760: 99.76
+	Mm
		899945 LHX5_MOUSE (55-401): 6.85e-65: 214: 24.52		LDB1_MOUSE (1-411): 0: 760: 99.76
+	Hs
		822644 LHX1_HUMAN (55-400): 3.03e-63: 210: 25.34		LDB1_HUMAN (1-411): 0: 760: 100.00
+	Mm
		925846 LHX1_MOUSE (55-400): 7.01e-63: 209: 25.34		LDB1_MOUSE (1-411): 0: 760: 99.76
+	Hs
		899923 ISL1_HUMAN (49-389): 3.38e-62: 205: 28.61		LDB1_HUMAN (1-411): 0: 760: 100.00
+	Mm
		899939 ISL1_MOUSE (49-389): 3.38e-62: 205: 28.61		LDB1_MOUSE (1-411): 0: 760: 99.76
+	Hs
		1199143 LHX9_HUMAN (53-338): 1.07e-57: 195: 25.93		LDB1_HUMAN (1-411): 0: 760: 100.00
+	Mm
		223242 LMX1B_MOUSE (1-402): 2.75e-99: 302: 98.01		LDB2_MOUSE (44-411): 0: 626: 76.42
+	Mm
		223259 LMX1A_MOUSE (24-402): 4.97e-85: 265: 62.60		LDB2_MOUSE (44-411): 0: 626: 76.42
+	Mm
		223247 LHX5_MOUSE (55-401): 6.85e-65: 214: 24.52		LDB2_MOUSE (44-411): 0: 626: 76.42
+	Mm
		223249 LHX1_MOUSE (55-400): 7.01e-63: 209: 25.34		LDB2_MOUSE (44-411): 0: 626: 76.42
+	Mm
		223246 ISL1_MOUSE (49-389): 3.38e-62: 205: 28.61		LDB2_MOUSE (44-411): 0: 626: 76.42
+	Hs
		210830 ISL1_HUMAN (49-389): 3.38e-62: 205: 28.61		LDB2_HUMAN (44-411): 0: 620: 76.69
+	Dm
		185755 Q9V472_DROME (56-382): 5.74e-64: 214: 25.00		O18353_DROME (8-391): 0: 594: 56.89
+	Dm
		1182724 Q9V472_DROME (56-382): 5.74e-64: 214: 25.00		Q7KVG9_DROME (8-391): 0: 593: 56.89
+	Dm
		185745 APTE_DROME (16-312): 2.32e-61: 207: 26.45		O18353_DROME (8-391): 0: 594: 56.89
+	Dm
		185763 Q9VTW3_DROME (10-400): 1.87e-60: 206: 35.02		O18353_DROME (8-391): 0: 594: 56.89
+	Dm
		669259 APTE_DROME (16-312): 2.32e-61: 207: 26.45		Q7KVG9_DROME (8-391): 0: 593: 56.89
+	Dm
		1182732 Q9VTW3_DROME (10-400): 1.87e-60: 206: 35.02		Q7KVG9_DROME (8-391): 0: 593: 56.89