HitPredict

Interactor 1: RAD1 (O60671)
Cell cycle checkpoint protein RAD1 (hRAD1) (Rad1-like DNA damage checkpoint protein)
Gene: RAD1

Interactor 2: RAD17 (O75943)
Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog)
Gene: RAD17

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.734

Property	Details
Experiments	27387238, 19535328, 12578958, 10884395, 11418864, 33961781
Identification Methods	pull down, biochemical, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000077 - DNA damage checkpoint signaling GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0006974 - DNA damage response
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 282 Hs			1 681
+	Hs
		238255 RAD1_HUMAN (1-282): 2.16e-126: 362: 100.00		RFC4_HUMAN (52-407): 2.53e-76: 251: 15.47
+	Hs
		238258 RAD1_HUMAN (1-282): 2.16e-126: 362: 100.00		RFC5_HUMAN (64-433): 4.14e-74: 244: 15.95
+	Hs
		238259 RAD1_HUMAN (1-282): 2.16e-126: 362: 100.00		RFC3_HUMAN (90-460): 1.82e-65: 221: 12.77
+	Sp
		605288 RAD1_SCHPO (24-277): 3.79e-89: 269: 28.36		RAD17_SCHPO (42-529): 1.08e-75: 256: 23.61
+	Sc
		697304 RAD17_YEAST (21-261): 3.61e-71: 226: 16.92		RAD24_YEAST (38-482): 3.94e-65: 229: 23.40