HitPredict

Interactor 1: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.914

Property	Details
Experiments	11694501, 15821101, 21806020, 11970898
Identification Methods	affinity chromatography technology, enzymatic study, phosphatase assay, coimmunoprecipitation, pull down
Interaction Type	physical association, direct interaction, dephosphorylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase, SH2~Y_phosphatase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0031904 - endosome lumen GO:0060397 - growth hormone receptor signaling pathway via JAK-STAT
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1132 Hs			1 435
+	Hs
		238402 JAK2_HUMAN (1-1132): 0: 1122: 100.00		PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44
+	Hs
		238399 JAK2_HUMAN (1-1132): 0: 1122: 100.00		PTN12_HUMAN (24-314): 1e-122: 376: 33.55
+	Hs
		573586 TYK2_HUMAN (38-1132): 0: 870: 35.49		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Mm
		420376 JAK2_MOUSE (1-1129): 0: 1108: 93.89		PTPRC_MOUSE (16-343): 7.2e-73: 250: 21.51
+	Rn
		783506 JAK2_RAT (1-1131): 0: 1124: 94.70		PTN11_RAT (39-274): 1.22e-48: 176: 38.80
+	Hs
		238401 JAK2_HUMAN (1-1132): 0: 1122: 100.00		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Mm
		719306 JAK2_MOUSE (1-1129): 0: 1108: 93.89		PTN11_MOUSE (39-274): 4.54e-49: 177: 38.80
+	Hs
		576990 TYK2_HUMAN (38-1132): 0: 870: 35.49		PTPRA_HUMAN (12-278): 9.1e-105: 330: 31.62
+	Hs
		238362 JAK2_HUMAN (1-1132): 0: 1122: 100.00		PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48
+	Mm
		728820 JAK2_MOUSE (1-1129): 0: 1108: 93.89		PTN1_MOUSE (313-433): 3.7e-17: 85: 7.75
+	Mm
		665989 JAK2_MOUSE (1-1129): 0: 1108: 93.89		PTN6_MOUSE (193-435): 5.39e-13: 72.7: 11.32
+	Hs
		669164 TYK2_HUMAN (38-1132): 0: 870: 35.49		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		665800 TYK2_HUMAN (38-1132): 0: 870: 35.49		PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48
+	Hs
		337339 ABL1_HUMAN (821-1131): 3.47e-94: 328: 32.05		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Dm
		337644 ABL_DROME (805-1128): 2.41e-93: 330: 30.15		LAR_DROME (8-278): 1.42e-99: 328: 30.80
+	Dm
		337661 ABL_DROME (805-1128): 2.41e-93: 330: 30.15		PTP61_DROME (1-300): 5.11e-93: 292: 49.68
+	Dm
		337643 ABL_DROME (805-1128): 2.41e-93: 330: 30.15		PTP69_DROME (14-277): 2.62e-71: 246: 26.18
+	Hs
		337358 ABL1_HUMAN (821-1131): 3.47e-94: 328: 32.05		PTN4_HUMAN (35-276): 4.21e-48: 178: 41.06
+	Dm
		337647 ABL_DROME (805-1128): 2.41e-93: 330: 30.15		PTP99_DROME (3-259): 3.67e-40: 155: 23.13
+	Hs
		789088 ABL2_HUMAN (821-1129): 1.95e-95: 332: 31.61		PTN18_HUMAN (342-434): 2.61e-17: 85.8: 12.87