Protein: HFE
Hereditary hemochromatosis protein (HLA-H)

Gene: HFE
Organism: Homo sapiens
Interactions: 130
UniProt ID: Q30201

Gene Ontology (top 5):
GO:0002725 - negative regulation of T cell cytokine production
GO:0005102 - signaling receptor binding
GO:0005615 - extracellular space
GO:0005654 - nucleoplasm
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

390596

TFR1
Transferrin receptor protein 1

7

4

Small-scale

0.961

High

963515

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

4

17

Small-scale

0.900

High

193700

TPSN
Tapasin

2

15

High-throughput

0.776

High

1180931

RN149
E3 ubiquitin-protein ligase RNF149

2

7

High-throughput

0.694

High

363360

EGFR
Epidermal growth factor receptor

1

17

High-throughput

0.691

High

409576

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

20

High-throughput

0.691

High

438888

CD1A
T-cell surface glycoprotein CD1a

1

17

High-throughput

0.691

High

469790

CATG
Cathepsin G

1

6

High-throughput

0.691

High

520867

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

16

High-throughput

0.691

High

841612

LIFR
Leukemia inhibitory factor receptor

1

5

High-throughput

0.691

High

939500

FCGRN
IgG receptor FcRn large subunit p51

1

16

High-throughput

0.691

High

1009146

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

20

High-throughput

0.691

High

1144602

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

6

High-throughput

0.691

High

1180936

RN128
E3 ubiquitin-protein ligase RNF128

1

8

High-throughput

0.691

High

1180941

BT2A2
Butyrophilin subfamily 2 member A2

1

7

High-throughput

0.691

High

1180945

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

6

High-throughput

0.691

High

1180947

HMR1
Major histocompatibility complex class I-related protein 1

1

17

High-throughput

0.691

High

1180963

RN167
E3 ubiquitin-protein ligase RNF167

1

7

High-throughput

0.691

High

1180968

NECT3
Nectin-3

1

2

High-throughput

0.691

High

567872

PRG2
Bone marrow proteoglycan

1

12

High-throughput

0.618

High

1180938

NEUFC
Neuferricin

1

3

High-throughput

0.618

High

1180977

FPRP
Prostaglandin F2 receptor negative regulator

1

1

High-throughput

0.618

High

1180983

TFR2
Transferrin receptor protein 2

1

3

Small-scale

0.618

High

161041

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

2

15

High-throughput

0.601

High

654975

ITA6
Integrin alpha-6

2

2

High-throughput

0.601

High

876254

NMU
Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36

2

1

High-throughput

0.601

High

1180926

LSR
Lipolysis-stimulated lipoprotein receptor

2

1

High-throughput

0.601

High

1180923

LYZL1
Lysozyme-like protein 1

1

0

High-throughput

0.578

High

787405

TGFR1
TGF-beta receptor type-1

1

3

High-throughput

0.575

High

1010470

EREP3
Protein ENTREP3

2

1

High-throughput

0.549

High

1180966

S38AA
Solute carrier family 38 member 10

2

3

High-throughput

0.549

High

239492

H6ST1
Heparan-sulfate 6-O-sulfotransferase 1

1

1

High-throughput

0.536

High

269671

PLXA2
Plexin-A2

1

8

High-throughput

0.536

High

341315

ECEL1
Endothelin-converting enzyme-like 1

1

5

High-throughput

0.536

High

548023

PSPC
Surfactant protein C

1

5

High-throughput

0.536

High

564913

ICAM2
Intercellular adhesion molecule 2

1

1

High-throughput

0.536

High

624197

FUT1
Galactoside alpha-(1,2)-fucosyltransferase 1

1

1

High-throughput

0.536

High

870821

GLRB
Glycine receptor subunit beta

1

6

High-throughput

0.536

High

1083105

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

6

High-throughput

0.536

High

1107781

SQSTM
Sequestosome-1

1

4

High-throughput

0.536

High

1120617

DAG1
Dystroglycan 1

1

1

High-throughput

0.536

High

1126018

GAS6
Growth arrest-specific protein 6

1

4

High-throughput

0.536

High

1132156

ICAM4
Intercellular adhesion molecule 4

1

1

High-throughput

0.536

High

1154799

KCNJ8
ATP-sensitive inward rectifier potassium channel 8

1

1

High-throughput

0.536

High

1164041

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

5

High-throughput

0.536

High

1180921

BRID5
BRICHOS domain-containing protein 5

1

5

High-throughput

0.536

High

1180933

SIA7C
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

1

13

High-throughput

0.536

High

1180934

DIK2A
Divergent protein kinase domain 2A

1

2

High-throughput

0.536

High

1180949

T106A
Transmembrane protein 106A

1

6

High-throughput

0.536

High

1180951

ASIC4
Acid-sensing ion channel 4

1

9

High-throughput

0.536

High

1180952

P121A
Nuclear envelope pore membrane protein POM 121

1

1

High-throughput

0.536

High

1180959

CNTP3
Contactin-associated protein-like 3

1

2

High-throughput

0.536

High

1180960

ABCA2
ATP-binding cassette sub-family A member 2

1

3

High-throughput

0.536

High

1180961

SEM6A
Semaphorin-6A

1

3

High-throughput

0.536

High

1180969

CNNM1
Metal transporter CNNM1

1

4

High-throughput

0.536

High

1180975

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

1

7

High-throughput

0.536

High

1180976

ADA22
Disintegrin and metalloproteinase domain-containing protein 22

1

15

High-throughput

0.536

High

1180978

P2RX2
P2X purinoceptor 2

1

1

High-throughput

0.536

High

1180984

ENTP4
Ectonucleoside triphosphate diphosphohydrolase 4

1

5

High-throughput

0.536

High

1180985

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

7

High-throughput

0.536

High

1180986

S27A6
Long-chain fatty acid transport protein 6

1

1

High-throughput

0.536

High

1180987

LRP12
Low-density lipoprotein receptor-related protein 12

1

5

High-throughput

0.536

High

1180988

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

5

High-throughput

0.536

High

141931

PODXL
Podocalyxin

1

0

High-throughput

0.513

High

238534

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.513

High

319152

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.513

High

322144

GLCE
D-glucuronyl C5-epimerase

1

0

High-throughput

0.513

High

342438

RPP29
Ribonuclease P protein subunit p29

1

0

High-throughput

0.513

High

467018

DAF
Complement decay-accelerating factor

1

0

High-throughput

0.513

High

981844

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.513

High

1038192

GCNT1
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

1

0

High-throughput

0.513

High

1106163

TUSC3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3

1

0

High-throughput

0.513

High

1180922

SAMD1
Sterile alpha motif domain-containing protein 1

1

0

High-throughput

0.513

High

1180928

TM219
Insulin-like growth factor-binding protein 3 receptor

1

0

High-throughput

0.513

High

1180930

VMA12
Vacuolar ATPase assembly protein VMA12

1

0

High-throughput

0.513

High

1180940

CANT1
Soluble calcium-activated nucleotidase 1

1

0

High-throughput

0.513

High

1180953

SENP5
Sentrin-specific protease 5

1

0

High-throughput

0.513

High

1180955

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.513

High

1180965

TAF9B
Transcription initiation factor TFIID subunit 9B

1

0

High-throughput

0.513

High

1180982

VANG2
Vang-like protein 2

1

0

High-throughput

0.513

High

1180943

ASM3B
Acid sphingomyelinase-like phosphodiesterase 3b

1

0

High-throughput

0.493

High

209378

SIA8C
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3

1

13

High-throughput

0.489

High

284956

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

2

High-throughput

0.489

High

337172

APOM
Apolipoprotein M

1

2

High-throughput

0.489

High

337261

ATS2
A disintegrin and metalloproteinase with thrombospondin motifs 2

1

5

High-throughput

0.489

High

355364

B3GT4
Beta-1,3-galactosyltransferase 4

1

6

High-throughput

0.489

High

643684

FUT4
Alpha-(1,3)-fucosyltransferase 4

1

2

High-throughput

0.489

High

1084043

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

13

High-throughput

0.489

High

1180917

UD3A2
UDP-glucuronosyltransferase 3A2

1

6

High-throughput

0.489

High

1180927

DYR2
Dihydrofolate reductase 2, mitochondrial

1

2

High-throughput

0.489

High

1180929

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

2

High-throughput

0.489

High

1180932

NETO2
Neuropilin and tolloid-like protein 2

1

6

High-throughput

0.489

High

1180935

PXYP1
2-phosphoxylose phosphatase 1

1

1

High-throughput

0.489

High

1180937

GPX8
Probable glutathione peroxidase 8

1

2

High-throughput

0.489

High

1180946

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

4

High-throughput

0.489

High

1180956

LMF2
Lipase maturation factor 2

1

2

High-throughput

0.489

High

1180962

SIA7D
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase

1

13

High-throughput

0.489

High

1180967

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.489

High

1180973

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

1

3

High-throughput

0.489

High

1180980

TM59L
Transmembrane protein 59-like

1

1

High-throughput

0.489

High

1180981

CCPG1
Cell cycle progression protein 1

1

2

High-throughput

0.489

High

1180990

POMT1
Protein O-mannosyl-transferase 1

1

2

High-throughput

0.489

High

218246

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

1180925

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

10

Small-scale

0.479

High

791430

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

390896

TRFE
Serotransferrin

1

0

Small-scale

0.458

High

277015

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

5

High-throughput

0.445

High

687106

MGAT1
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

1

3

High-throughput

0.445

High

1083172

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

6

High-throughput

0.445

High

1180958

AP1M1
AP-1 complex subunit mu-1

1

2

High-throughput

0.445

High

633849

MPRD
Cation-dependent mannose-6-phosphate receptor

1

0

High-throughput

0.426

High

1180919

MYORG
Myogenesis-regulating glycosidase

1

4

High-throughput

0.407

High

1180924

ILDR2
Immunoglobulin-like domain-containing receptor 2

1

1

High-throughput

0.407

High

1180942

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

4

High-throughput

0.407

High

1180950

KCD12
BTB/POZ domain-containing protein KCTD12

1

1

High-throughput

0.407

High

1180970

C1GLT
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

1

6

High-throughput

0.407

High

416618

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

0

High-throughput

0.279

Low

1180918

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.279

Low

1180920

TYW1B
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B

1

0

High-throughput

0.279

Low

1180939

THEM6
Protein THEM6

1

0

High-throughput

0.279

Low

1180948

NXPE3
NXPE family member 3

1

0

High-throughput

0.279

Low

1180954

TM87B
Transmembrane protein 87B

1

0

High-throughput

0.279

Low

1180957

CA043
Protein C1orf43

1

0

High-throughput

0.279

Low

1180964

DEFM
Peptide deformylase, mitochondrial

1

0

High-throughput

0.279

Low

1180971

CHST7
Carbohydrate sulfotransferase 7

1

0

High-throughput

0.279

Low

1180979

B4GT7
Beta-1,4-galactosyltransferase 7

1

0

High-throughput

0.279

Low

1180989

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.279

Low

1180944

PIGB
GPI alpha-1,2-mannosyltransferase 3

1

0

High-throughput

0.232

Low

1180972

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.232

Low

1180974

TM160
Transmembrane protein 160

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025