HitPredict

Interactor 1: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: TYK2 (P29597)
Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)
Gene: TYK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 26175413
Identification Methods anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains FERM_F1~FERM_F1, FERM_F1~FERM_F2, FERM_F1~Jak1_Phl, FERM_F2~FERM_F2, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005131 - growth hormone receptor binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 25 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1132
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024