HitPredict

Interactor 1: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9632636
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_F1~SH2, BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, SH2~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0120162 - positive regulation of cold-induced thermogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1132 Hs			1 594
+	Hs
		238345 JAK2_HUMAN (1-1132): 0: 1122: 100.00		VAV_HUMAN (36-594): 3.93e-139: 426: 14.11
+	Hs
		145961 JAK2_HUMAN (1-1132): 0: 1122: 100.00		SH2B2_HUMAN (301-581): 7.5e-55: 198: 16.29
+	Hs
		238380 JAK2_HUMAN (1-1132): 0: 1122: 100.00		TEC_HUMAN (293-590): 2.81e-52: 191: 12.33
+	Hs
		238330 JAK2_HUMAN (1-1132): 0: 1122: 100.00		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		238342 JAK2_HUMAN (1-1132): 0: 1122: 100.00		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		548650 TYK2_HUMAN (38-1132): 0: 870: 35.49		VAV_HUMAN (36-594): 3.93e-139: 426: 14.11
+	Hs
		238332 JAK2_HUMAN (1-1132): 0: 1122: 100.00		LYN_HUMAN (409-593): 7.45e-46: 171: 17.19
+	Mm
		403446 JAK2_MOUSE (1-1129): 0: 1108: 93.89		SRC_MOUSE (443-590): 1.24e-46: 173: 22.08
+	Mm
		980968 JAK2_MOUSE (1-1129): 0: 1108: 93.89		YES_MOUSE (441-592): 1.43e-46: 173: 20.89
+	Hs
		238395 JAK2_HUMAN (1-1132): 0: 1122: 100.00		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		412039 TYK2_HUMAN (38-1132): 0: 870: 35.49		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		433605 TYK2_HUMAN (38-1132): 0: 870: 35.49		LYN_HUMAN (409-593): 7.45e-46: 171: 17.19
+	Hs
		337333 ABL1_HUMAN (821-1131): 3.47e-94: 328: 32.05		VAV_HUMAN (36-594): 3.93e-139: 426: 14.11
+	Hs
		412070 ABL2_HUMAN (821-1129): 1.95e-95: 332: 31.61		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		522840 ABL2_HUMAN (821-1129): 1.95e-95: 332: 31.61		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		442789 ABL2_HUMAN (821-1129): 1.95e-95: 332: 31.61		HCK_HUMAN (406-593): 7.97e-46: 171: 18.78
+	Hs
		337307 ABL1_HUMAN (821-1131): 3.47e-94: 328: 32.05		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		337329 ABL1_HUMAN (821-1131): 3.47e-94: 328: 32.05		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		337315 ABL1_HUMAN (821-1131): 3.47e-94: 328: 32.05		HCK_HUMAN (406-593): 7.97e-46: 171: 18.78
+	Hs
		789054 ABL2_HUMAN (821-1129): 1.95e-95: 332: 31.61		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89