HitPredict

Interactor 1: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: CISH (Q9NSE2)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	1.00	0.527

Property	Details
Experiments	34989544
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SOCS_box
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1132 Hs			1 258
+	Hs
		147366 JAK2_HUMAN (1-1132): 0: 1122: 100.00		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		238342 JAK2_HUMAN (1-1132): 0: 1122: 100.00		SRC_HUMAN (50-248): 5.15e-42: 152: 16.11
+	Hs
		238330 JAK2_HUMAN (1-1132): 0: 1122: 100.00		FYN_HUMAN (39-248): 8.37e-42: 151: 13.06
+	Hs
		238424 JAK2_HUMAN (1-1132): 0: 1122: 100.00		SOCS4_HUMAN (47-257): 2.54e-42: 151: 25.35
+	Rn
		102468 JAK2_RAT (1-1131): 0: 1124: 94.70		G3V6B4_RAT (55-258): 1.49e-41: 143: 28.16
+	Hs
		181748 JAK2_HUMAN (1-1132): 0: 1122: 100.00		SOCS1_HUMAN (55-258): 2e-42: 145: 28.16
+	Mm
		980968 JAK2_MOUSE (1-1129): 0: 1108: 93.89		YES_MOUSE (50-213): 6.22e-43: 154: 16.28
+	Mm
		403446 JAK2_MOUSE (1-1129): 0: 1108: 93.89		SRC_MOUSE (50-248): 7.06e-42: 151: 16.11
+	Mm
		222647 JAK2_MOUSE (1-1129): 0: 1108: 93.89		SOCS5_MOUSE (59-257): 1.8e-40: 148: 25.87
+	Mm
		193352 JAK2_MOUSE (1-1129): 0: 1108: 93.89		SOCS1_MOUSE (55-258): 2.79e-41: 142: 28.16
+	Mm
		193387 JAK2_MOUSE (1-1129): 0: 1108: 93.89		SOCS3_MOUSE (43-254): 1.24e-40: 141: 29.77
+	Rn
		783506 JAK2_RAT (1-1131): 0: 1124: 94.70		PTN11_RAT (77-222): 8.65e-26: 107: 19.46
+	Hs
		238401 JAK2_HUMAN (1-1132): 0: 1122: 100.00		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		238360 JAK2_HUMAN (1-1132): 0: 1122: 100.00		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Mm
		719306 JAK2_MOUSE (1-1129): 0: 1108: 93.89		PTN11_MOUSE (77-222): 7.34e-26: 107: 19.46
+	Hs
		238332 JAK2_HUMAN (1-1132): 0: 1122: 100.00		LYN_HUMAN (41-209): 8.26e-18: 84.2: 19.21
+	Mm
		643096 JAK2_MOUSE (1-1129): 0: 1108: 93.89		P85A_MOUSE (52-188): 4.14e-21: 94.1: 16.06
+	Hs
		146598 TYK2_HUMAN (38-1132): 0: 870: 35.49		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Hs
		412039 TYK2_HUMAN (38-1132): 0: 870: 35.49		FYN_HUMAN (39-248): 8.37e-42: 151: 13.06
+	Hs
		181802 TYK2_HUMAN (38-1132): 0: 870: 35.49		SOCS1_HUMAN (55-258): 2e-42: 145: 28.16