HitPredict

Interactor 1: IMA7 (O60684)
Importin subunit alpha-7 (Karyopherin subunit alpha-6)
Gene: KPNA6

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 536 Hs			1 488
+	Hs
		134940 IMA3_HUMAN (4-536): 9.52e-152: 446: 47.10		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		131481 IMA4_HUMAN (4-536): 4.93e-148: 436: 45.98		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		853672 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		853401 IMA1_HUMAN (1-536): 5.59e-142: 421: 44.92		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		238671 IMA7_HUMAN (1-536): 7e-160: 467: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		134892 IMA3_HUMAN (4-536): 9.52e-152: 446: 47.10		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		131432 IMA4_HUMAN (4-536): 4.93e-148: 436: 45.98		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		853589 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		853269 IMA1_HUMAN (1-536): 5.59e-142: 421: 44.92		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Sp
		223485 IMA2_SCHPO (11-536): 4.57e-144: 427: 52.26		CLR6_SCHPO (6-406): 0: 563: 60.89
+	Mm
		192637 IMA4_MOUSE (4-536): 9.19e-150: 441: 46.36		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89
+	Hs
		853744 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04