HitPredict

Interactor 1: IMA7 (O60684)
Importin subunit alpha-7 (Karyopherin subunit alpha-6)
Gene: KPNA6

Interactor 2: CHD8 (Q9HCK8)
Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)
Gene: CHD8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26496610, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 536 Hs			1 2581
+	Hs
		134969 IMA3_HUMAN (4-536): 9.52e-152: 446: 47.10		CHD8_HUMAN (1-2581): 0: 2318: 100.00
+	Hs
		168673 IMA6_HUMAN (1-536): 3.72e-149: 440: 83.67		CHD8_HUMAN (1-2581): 0: 2318: 100.00
+	Mm
		192636 IMA4_MOUSE (4-536): 9.19e-150: 441: 46.36		CHD8_MOUSE (1-2581): 0: 2316: 95.40
+	Hs
		853720 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		CHD8_HUMAN (1-2581): 0: 2318: 100.00
+	Mm
		1000155 IMA5_MOUSE (4-536): 4.03e-145: 429: 79.74		CHD8_MOUSE (1-2581): 0: 2316: 95.40
+	Zm
		11289 A0A1D6FC42_MAIZE (3-536): 4.91e-151: 444: 53.79		A0A1D6IBX9_MAIZE (368-2274): 0: 1040: 20.83
+	Zm
		12493 A0A1D6FMC0_MAIZE (3-536): 2.82e-148: 439: 50.09		A0A1D6IBX9_MAIZE (368-2274): 0: 1040: 20.83
+	Hs
		131423 IMA4_HUMAN (4-536): 4.93e-148: 436: 45.98		CHD3_HUMAN (385-2065): 0: 1037: 23.37
+	Hs
		853580 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		CHD3_HUMAN (385-2065): 0: 1037: 23.37
+	Hs
		238679 IMA7_HUMAN (1-536): 7e-160: 467: 100.00		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		134899 IMA3_HUMAN (4-536): 9.52e-152: 446: 47.10		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		168636 IMA6_HUMAN (1-536): 3.72e-149: 440: 83.67		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		853602 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		229344 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		SMCA5_HUMAN (687-1722): 0: 886: 26.82
+	Hs
		658643 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		SMCA1_HUMAN (654-1705): 0: 875: 26.13
+	Hs
		131405 IMA4_HUMAN (4-536): 4.93e-148: 436: 45.98		SMCA4_HUMAN (69-1478): 0: 806: 23.14
+	Hs
		853716 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		Q9HBD4_HUMAN (69-1434): 0: 807: 23.44
+	Hs
		846902 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		SMCA4_HUMAN (69-1478): 0: 806: 23.14
+	Hs
		846726 IMA5_HUMAN (4-536): 1.39e-146: 433: 80.11		SMCA2_HUMAN (101-1489): 0: 797: 22.14
+	Hs
		846725 IMA1_HUMAN (1-536): 5.59e-142: 421: 44.92		SMCA2_HUMAN (101-1489): 0: 797: 22.14