Protein: SIK3
Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)

Gene: SIK3
Organism: Homo sapiens
Interactions: 70
UniProt ID: Q9Y2K2

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

943668

SIK1
Serine/threonine-protein kinase SIK1

2

16

High-throughput

0.811

High

605858

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

2

19

High-throughput

0.793

High

990895

1433Z
14-3-3 protein zeta/delta

5

20

Small-scale

0.726

High

972160

1433E
14-3-3 protein epsilon

4

20

Small-scale

0.694

High

1049930

1433F
14-3-3 protein eta

4

20

Small-scale

0.694

High

462067

HS90A
Heat shock protein HSP 90-alpha

1

9

High-throughput

0.691

High

468938

HS90B
Heat shock protein HSP 90-beta

1

9

High-throughput

0.691

High

1106139

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

3

High-throughput

0.691

High

1417913

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.691

High

873495

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

4

10

High-throughput

0.691

High

730378

1433B
14-3-3 protein beta/alpha

3

20

Small-scale

0.671

High

1062416

PP2BA
Protein phosphatase 3 catalytic subunit alpha

3

9

High-throughput

0.667

High

1151690

TRIP6
Thyroid receptor-interacting protein 6

2

1

High-throughput

0.640

High

691561

1433T
14-3-3 protein theta

2

20

Small-scale

0.621

High

1397763

CANB2
Calcineurin subunit B type 2

1

10

High-throughput

0.618

High

1419822

OSBL8
Oxysterol-binding protein-related protein 8

1

2

High-throughput

0.618

High

214077

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

8

Small-scale

0.618

High

425684

ISG15
Ubiquitin-like protein ISG15

1

7

High-throughput

0.618

High

1095486

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

19

Small-scale

0.618

High

1256169

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.618

High

730975

1433S
14-3-3 protein sigma

2

20

Small-scale

0.584

High

1093998

TRAF1
TNF receptor-associated factor 1

1

3

High-throughput

0.573

High

967047

1433G
14-3-3 protein gamma

1

20

High-throughput

0.554

High

610949

TCPA
T-complex protein 1 subunit alpha

1

3

High-throughput

0.536

High

756417

MCM7
DNA replication licensing factor MCM7

1

1

High-throughput

0.536

High

876232

TCPE
T-complex protein 1 subunit epsilon

1

4

High-throughput

0.536

High

882224

TCPG
T-complex protein 1 subunit gamma

1

4

High-throughput

0.536

High

899290

TCPQ
T-complex protein 1 subunit theta

1

5

High-throughput

0.536

High

899637

TCPD
T-complex protein 1 subunit delta

1

3

High-throughput

0.536

High

903525

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

3

High-throughput

0.536

High

993038

RACK1
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.536

High

1007346

TCPB
T-complex protein 1 subunit beta

1

4

High-throughput

0.536

High

1133059

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.536

High

1371035

TNPO1
Transportin-1

1

1

High-throughput

0.536

High

1407638

TCPH
T-complex protein 1 subunit eta

1

4

High-throughput

0.536

High

1435479

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

1451432

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.536

High

1462278

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

High-throughput

0.536

High

1014666

SMAD3
Mothers against decapentaplegic homolog 3

1

2

Small-scale

0.515

High

1153950

SMAD2
Mothers against decapentaplegic homolog 2

1

2

Small-scale

0.515

High

844112

HD
Huntingtin

1

1

High-throughput

0.515

High

1462748

HDAC5
Histone deacetylase 5

1

10

Small-scale

0.501

High

158901

AP3D1
AP-3 complex subunit delta-1

1

1

High-throughput

0.489

High

179417

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

High-throughput

0.489

High

731718

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.489

High

773694

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.489

High

1144224

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.489

High

1370039

GSLG1
Golgi apparatus protein 1

1

1

High-throughput

0.489

High

1490796

SGT1
Protein SGT1 homolog

1

3

High-throughput

0.489

High

404556

GCR
Glucocorticoid receptor

1

6

High-throughput

0.479

High

869098

TISD
mRNA decay activator protein ZFP36L2

1

2

High-throughput

0.479

High

1452641

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

3

Small-scale

0.479

High

530620

TAU
Microtubule-associated protein tau

1

11

Small-scale

0.445

High

1198359

CRTC2
CREB-regulated transcription coactivator 2

1

5

Small-scale

0.445

High

1437416

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

106888

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

174643

TRI66
Tripartite motif-containing protein 66

1

5

High-throughput

0.437

High

905307

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.437

High

1339571

NEUA
N-acylneuraminate cytidylyltransferase

1

1

High-throughput

0.437

High

1391220

BICD1
Protein bicaudal D homolog 1

1

8

High-throughput

0.437

High

1258624

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

15

High-throughput

0.407

High

64159

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.279

Low

238762

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

0

High-throughput

0.279

Low

933249

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.279

Low

1437984

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.279

Low

1447646

SAS10
Something about silencing protein 10

1

0

High-throughput

0.279

Low

1201339

OCAD2
OCIA domain-containing protein 2

1

0

High-throughput

0.269

Low

360296

COX1
Cytochrome c oxidase subunit 1

1

0

High-throughput

0.249

Low

377789

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1270450

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025