HitPredict

Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: CO3 (P01024)
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.618

Property	Details
Experiments	33961781, 37207277
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 1663
+	Hs
		239732 HCN1_HUMAN (1-890): 0: 684: 100.00		CO4A_HUMAN (16-1661): 0: 1624: 28.20
+	Hs
		66360 HCN1_HUMAN (1-890): 0: 684: 100.00		A2ML1_HUMAN (8-1496): 0: 1097: 23.50
+	Hs
		72257 HCN1_HUMAN (1-890): 0: 684: 100.00		B3KVV6_HUMAN (164-1496): 0: 972: 22.90