Protein: MTHR
Methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.53)

Gene: MTHR, MTHFR
Organism: Homo sapiens
Interactions: 46
UniProt ID: P42898

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0001843 - neural tube closure
GO:0004489 - methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0005829 - cytosol
GO:0006555 - methionine metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

792229

MTHR
Methylenetetrahydrofolate reductase

1

2

Small-scale

0.647

High

206729

B2L11
Bcl-2-like protein 11

3

0

High-throughput

0.638

High

792235

BOREA
Borealin

3

0

High-throughput

0.638

High

580405

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

3

1

High-throughput

0.609

High

792232

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

3

1

High-throughput

0.609

High

792246

NOX5
NADPH oxidase 5

2

0

High-throughput

0.602

High

600523

EPHA1
Ephrin type-A receptor 1

2

1

High-throughput

0.574

High

792241

KCNV2
Potassium voltage-gated channel subfamily V member 2

2

1

High-throughput

0.574

High

489382

BCL2
Apoptosis regulator Bcl-2

1

0

High-throughput

0.513

High

792231

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.513

High

792248

TLR10
Toll-like receptor 10

1

1

High-throughput

0.489

High

792249

KCNF1
Potassium voltage-gated channel subfamily F member 1

1

1

High-throughput

0.489

High

792252

TLR9
Toll-like receptor 9

1

1

High-throughput

0.489

High

238640

IMA7
Importin subunit alpha-7

1

0

High-throughput

0.458

High

262385

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

792244

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

High-throughput

0.458

High

665447

EPHA8
Ephrin type-A receptor 8

1

1

High-throughput

0.437

High

792255

RASF1
Ras association domain-containing protein 1

3

0

High-throughput

0.347

High

245480

NSMA
Sphingomyelin phosphodiesterase 2

3

0

High-throughput

0.345

High

49133

TM223
Transmembrane protein 223

2

0

High-throughput

0.328

High

642826

3BHS2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

2

0

High-throughput

0.328

High

792234

TIGD6
Tigger transposable element-derived protein 6

2

0

High-throughput

0.328

High

792238

SPT19
Spermatogenesis-associated protein 19, mitochondrial

2

0

High-throughput

0.328

High

792242

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

0

High-throughput

0.328

High

792253

PCDBG
Protocadherin beta-16

2

0

High-throughput

0.328

High

792251

SP110
Sp110 nuclear body protein

2

0

High-throughput

0.318

High

130292

BT3A1
Butyrophilin subfamily 3 member A1

1

0

High-throughput

0.279

Low

161793

ZN263
Zinc finger protein 263

1

0

High-throughput

0.279

Low

217297

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.279

Low

473050

BNIP5
Protein BNIP5

1

0

High-throughput

0.279

Low

648277

G0S2
G0/G1 switch protein 2

1

0

High-throughput

0.279

Low

792230

GDF10
Growth/differentiation factor 10

1

0

High-throughput

0.279

Low

792236

CX066
Uncharacterized protein CXorf66

1

0

High-throughput

0.279

Low

792239

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.279

Low

792240

SYT2
Synaptotagmin-2

1

0

High-throughput

0.279

Low

792245

COX42
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

1

0

High-throughput

0.279

Low

792247

DCR1C
Protein artemis

1

0

High-throughput

0.279

Low

792250

ZN556
Zinc finger protein 556

1

0

High-throughput

0.279

Low

321380

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

0

High-throughput

0.265

Low

294487

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

792233

CUL4A
Cullin-4A

1

0

High-throughput

0.249

Low

792237

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

792243

ARK2N
Protein ARK2N

1

0

High-throughput

0.249

Low

792254

TMPS4
Transmembrane protease serine 4

1

0

High-throughput

0.249

Low

401583

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024