HitPredict

Interactor 1: SNX2 (O60749)
Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9)
Gene: SNX2

Interactor 2: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	9819414
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005764 - lysosome GO:0010008 - endosome membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 519 Hs			1 1382
+	Rn
		71355 B2RYP4_RAT (1-519): 4.37e-147: 433: 97.69		INSR_RAT (1-1382): 0: 1527: 94.44
+	Hs
		411380 SNX1_HUMAN (2-519): 1.54e-123: 373: 59.32		INSR_HUMAN (1-1382): 0: 1530: 100.00
+	Mm
		546277 SNX9_MOUSE (2-515): 8.45e-91: 291: 15.49		INSR_MOUSE (1-1382): 0: 1509: 94.36
+	Hs
		240333 SNX2_HUMAN (1-519): 5.7e-150: 440: 100.00		IGF1R_HUMAN (31-1380): 0: 1353: 56.11
+	Hs
		307875 SNX4_HUMAN (93-513): 2.45e-73: 241: 18.20		INSR_HUMAN (1-1382): 0: 1530: 100.00
+	Hs
		411539 SNX5_HUMAN (123-517): 2.28e-68: 227: 22.89		INSR_HUMAN (1-1382): 0: 1530: 100.00
+	Hs
		411527 SNX6_HUMAN (113-517): 4.05e-68: 226: 19.06		INSR_HUMAN (1-1382): 0: 1530: 100.00
+	Hs
		435636 SNX1_HUMAN (2-519): 1.54e-123: 373: 59.32		IGF1R_HUMAN (31-1380): 0: 1353: 56.11
+	Mm
		1141340 SNX9_MOUSE (2-515): 8.45e-91: 291: 15.49		IGF1R_MOUSE (19-1380): 0: 1351: 54.72
+	Hs
		435813 SNX5_HUMAN (123-517): 2.28e-68: 227: 22.89		IGF1R_HUMAN (31-1380): 0: 1353: 56.11
+	Hs
		435805 SNX6_HUMAN (113-517): 4.05e-68: 226: 19.06		IGF1R_HUMAN (31-1380): 0: 1353: 56.11
+	Hs
		240370 SNX2_HUMAN (1-519): 5.7e-150: 440: 100.00		EPHA5_HUMAN (567-1319): 1.23e-176: 555: 20.98
+	Hs
		872507 SNX6_HUMAN (113-517): 4.05e-68: 226: 19.06		EPHA5_HUMAN (567-1319): 1.23e-176: 555: 20.98
+	Hs
		445888 SNX5_HUMAN (123-517): 2.28e-68: 227: 22.89		ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63
+	Hs
		240327 SNX2_HUMAN (1-519): 5.7e-150: 440: 100.00		NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62
+	Hs
		384051 SNX9_HUMAN (3-515): 6.14e-93: 296: 16.64		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		384801 SNX1_HUMAN (2-519): 1.54e-123: 373: 59.32		NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62
+	Hs
		674416 SNX1_HUMAN (2-519): 1.54e-123: 373: 59.32		UFO_HUMAN (789-1294): 1.77e-61: 229: 31.09
+	Hs
		385804 SNX9_HUMAN (3-515): 6.14e-93: 296: 16.64		NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62
+	Hs
		1081648 SNX7_HUMAN (112-512): 6e-80: 256: 22.44		NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43