HitPredict

Interactor 1: DKC1 (O60832)
H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)
Gene: DKC1

Interactor 2: NOP10 (Q9NPE3)
H/ACA ribonucleoprotein complex subunit 3 (Nucleolar protein 10) (Nucleolar protein family A member 3) (snoRNP protein NOP10)
Gene: NOP10

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.945

The method score is based on:

Property	Details
Experiments	33961781, 35271311, 26186194, 28514442, 19095616, 19179534
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	DKCLD~Nop10p, Nop10p~TruB_C_2, Nop10p~TruB_N
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005697 - telomerase holoenzyme complex GO:0007004 - telomere maintenance via telomerase GO:0031118 - rRNA pseudouridine synthesis and 7 others more... GO:0031120 - snRNA pseudouridine synthesis GO:0031429 - box H/ACA snoRNP complex GO:0034513 - box H/ACA snoRNA binding GO:0070034 - telomerase RNA binding GO:0072589 - box H/ACA scaRNP complex GO:0090661 - box H/ACA telomerase RNP complex GO:1904874 - positive regulation of telomerase RNA localization to Cajal body
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	514
Hs

1	64

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024